ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2021-1-147-157ssmu-4288Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESБиохимические, молекулярно-генетические и клинические аспекты COVID-2019Biochemical, molecular genetic and clinical aspects of COVID-2019https://orcid.org/0000-0003-2268-4186КаштановаЕ. В.KashtanovaE. V.

 д-р биол. наук, доцент, зав. лабораторией клинических, биохимических и гормональных исследований терапевтических заболеваний

Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1

 175/1, Boris Bogatkov Str., Novosibirsk, 630089, Russian Federation 

elekastanova@yandex.ruhttps://orcid.org/0000-0001-6108-1025ШахтшнейдерЕ. В.ShakhtshneiderE. V.

 канд. мед. наук, зам. руководителя  

Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1

 175/1, Boris Bogatkov Str., Novosibirsk, 630089, Russian Federation 

https://orcid.org/0000-0003-0077-3823КручининаМ. В.KruchininaM. V.

 д-р мед. наук, вед. науч. сотрудник, лаборатория гастроэнтерологии

Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1

 175/1, Boris Bogatkov Str., Novosibirsk, 630089, Russian Federation 

https://orcid.org/0000-0003-1348-0253ЛогвиненкоИ. И.LogvinenkoI. I.

 д-р мед. наук, профессор, вед. науч. сотрудник, лаборатория профилактической медицины, зам. руководителя

Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1

 175/1, Boris Bogatkov Str., Novosibirsk, 630089, Russian Federation 

https://orcid.org/0000-0001-5316-4664СтрюковаЕ. В.StriukovaE. V.

 аспирант, мл. науч. сотрудник, лаборатория клинических, биохимических и гормональных исследований терапевтических заболеваний

Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1

 175/1, Boris Bogatkov Str., Novosibirsk, 630089, Russian Federation 

https://orcid.org/0000-0002-4936-8362РагиноЮ. И.RaginoYu. I.

 д-р мед. наук, профессор, чл.-корр. РАН, руководитель 

Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1

 175/1, Boris Bogatkov Str., Novosibirsk, 630089, Russian Federation 

Научно-исследовательский институт терапии и профилактической медицины (НИИТПМ) – филиал Федерального исследовательского центра «Институт цитологии и генетики» Сибирского отделения Российской академии наук (ФИЦ ИЦиГ СО РАН)РоссияResearch Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesRussian Federation202110042021201147157Copyright © Каштанова Е.В., Шахтшнейдер Е.В., Кручинина М.В., Логвиненко И.И., Стрюкова Е.В., Рагино Ю.И., 20212021Каштанова Е.В., Шахтшнейдер Е.В., Кручинина М.В., Логвиненко И.И., Стрюкова Е.В., Рагино Ю.И.Kashtanova E.V., Shakhtshneider E.V., Kruchinina M.V., Logvinenko I.I., Striukova E.V., Ragino Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/4288

 Пандемия коронавирусной инфекции в 2020 г. потенцировала проведение большого числа исследований в мире в области этиопатогенеза и клинико-морфологических проявлений  COVID-2019. Представлены биохимические, молекулярно-генетические и клинические аспекты COVID-2019. 

 The 2020 coronavirus infection pandemic has potentiated a large number of studies in the world on the etiopathogenesis, clinical and morphological manifestations of COVID-2019 infection. This review presents biochemical, molecular genetic and clinical aspects of COVID-2019. 

COVID-19коронавирусцитокиныполиморфизмCOVID-19coronaviruscytokinespolymorphismРабота выполнена по государственному заданию в рамках бюджетной темы № АААА-А17-117112850280-2.The work was performed according to the State task in the framework of the budget theme no. AAAA17-11711285 280-2.ReferencesSevere acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome. Gen Bank: MN908947.3. URL: https://www.ncbi.nlm.nih.gov/nuccore/MN908947.Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome. Gen Bank: MN908947.3. URL: https://www.ncbi.nlm.nih.gov/nuccore/MN908947.WHO. Country & Technical Guidance – Coronavirus disease (COVID-19). URL: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/ naming-thecoronavirus-disease-(covid-2019)-and-the-virus-that-causes-it.WHO. Country & Technical Guidance – Coronavirus disease (COVID-19). URL: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/ naming-thecoronavirus-disease-(covid-2019)-and-the-virus-that-causes-it.De Wilde A.H., Snijder E.J., Kikkert M., van Hemert M.J. Host factors in coronavirus replication. In roles of host gene and non-coding rna expression in virus infection. Tripp R.A., Tompkins S.M. (еds). Springer International Publishing: Cham, Switzerland. 2018; 1–42. DOI: 10.1007/82_2017_25.De Wilde A.H., Snijder E.J., Kikkert M., van Hemert M.J. Host factors in coronavirus replication. In roles of host gene and non-coding rna expression in virus infection. Tripp R.A., Tompkins S.M. (еds). Springer International Publishing: Cham, Switzerland. 2018; 1–42. DOI: 10.1007/82_2017_25.Kuba K., Imai Y., Penninger J.M. Angiotensin-converting enzyme 2 in lung diseases. Curr. Opin. Pharmacol. 2006; 6 (3): 271–276. DOI: 10.1016/j.coph.2006.03.001.Kuba K., Imai Y., Penninger J.M. Angiotensin-converting enzyme 2 in lung diseases. Curr. Opin. Pharmacol. 2006; 6 (3): 271–276. DOI: 10.1016/j.coph.2006.03.001.Letko М., Marzi А., Munster У. Functional assessment of сеll entry and receptor usage for SAR5-СоV-2 and other lineage В betacoronaviruses. Nat. Microblol. 2020; 5 (4): 562–569. DOI: 10.1038/s41564-020-0688-y.Letko М., Marzi А., Munster У. Functional assessment of сеll entry and receptor usage for SAR5-СоV-2 and other lineage В betacoronaviruses. Nat. Microblol. 2020; 5 (4): 562–569. DOI: 10.1038/s41564-020-0688-y.Li F. Structure, function, and evolution of coronavirus spike proteins. Annu. Rev. Virol. 2016; 3 (1): 237–261. DOI: 10.1146/annurev-virology-110615-042301.Li F. Structure, function, and evolution of coronavirus spike proteins. Annu. Rev. Virol. 2016; 3 (1): 237–261. DOI: 10.1146/annurev-virology-110615-042301.Li W., Moore M.J., Vasilieva N., Sui J., Wong S.K., Berne M.A., Somasundaran M., Sullivan J.L., Luzuriaga K., Greenough T.C. et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426 (6965): 450–454. DOI: 10.1038/nature02145.Li W., Moore M.J., Vasilieva N., Sui J., Wong S.K., Berne M.A., Somasundaran M., Sullivan J.L., Luzuriaga K., Greenough T.C. et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426 (6965): 450–454. DOI: 10.1038/nature02145.Yan R., Zhang Y., Li Y., Xia L., Guo Y., Zhou Q. Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science. 2020; 27; 367 (6485): 1444–1448. DOI: 10.1126/science.abb2762.Yan R., Zhang Y., Li Y., Xia L., Guo Y., Zhou Q. Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science. 2020; 27; 367 (6485): 1444–1448. DOI: 10.1126/science.abb2762.Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., Si H.R., Zhu Y., Li B., Huang C.L. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579 (7798): 270–273. DOI: 10.1038/s41586-020-2012-7.Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., Si H.R., Zhu Y., Li B., Huang C.L. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579 (7798): 270–273. DOI: 10.1038/s41586-020-2012-7.Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S., Schiergens T.S., Herrler G., Wu N.-H., Nitsche A. SARS-CoV-2 cell entry depends on ace2 and tmprss2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181 (2): 271–280. DOI: 10.1016/j.cell.2020.02.052.Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S., Schiergens T.S., Herrler G., Wu N.-H., Nitsche A. SARS-CoV-2 cell entry depends on ace2 and tmprss2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181 (2): 271–280. DOI: 10.1016/j.cell.2020.02.052.Donoghue M., Hsieh F., Baronas E., Godbout K. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ. Res. 2000; 87 (5): е1–9. DOI: 10.1161/01.res.87.5.e1.Donoghue M., Hsieh F., Baronas E., Godbout K. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ. Res. 2000; 87 (5): е1–9. DOI: 10.1161/01.res.87.5.e1.Saab Y.B., Gard P., Overall A. The geographic distribution of the ACE II genotype: a novel finding. Genet. Res. 2007; 89 (4): 259–267. DOI: 10.1017/S0016672307009019.Saab Y.B., Gard P., Overall A. The geographic distribution of the ACE II genotype: a novel finding. Genet. Res. 2007; 89 (4): 259–267. DOI: 10.1017/S0016672307009019.Delanghe J.R., Speeckaert M.M., De Buyzere M.L. The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections. Clin. Chim. Acta. 2020; 505: 192–193. DOI: 10.1016/j.cca.2020.03.031.Delanghe J.R., Speeckaert M.M., De Buyzere M.L. The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections. Clin. Chim. Acta. 2020; 505: 192–193. DOI: 10.1016/j.cca.2020.03.031.Романов БК. Коронавирусная инфекция COVID-2019. Безопасность и риск фармакотерапии. 2020; 8 (1): 3–8. DOI: 10.30895/2312-7821-2020-8-1-3-8.Романов БК. Коронавирусная инфекция COVID-2019. Безопасность и риск фармакотерапии. 2020; 8 (1): 3–8. DOI: 10.30895/2312-7821-2020-8-1-3-8.Jin Y., Yang H., Ji W., Wu W., Chen S., Zhang W. Duan G. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020; 12 (4): 372. DOI: 10.3390/v12040372.Jin Y., Yang H., Ji W., Wu W., Chen S., Zhang W. Duan G. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020; 12 (4): 372. DOI: 10.3390/v12040372.Mousavizadeh L., Ghasemi S. Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection. 2020 March 31. DOI: 10.1016/j.jmii.2020.03.022.Mousavizadeh L., Ghasemi S. Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection. 2020 March 31. DOI: 10.1016/j.jmii.2020.03.022.Rothan H.A., Byrareddy S.N. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity. 2020; 109: 102433. DOI: 10.1016/j.jaut.2020.102433.Rothan H.A., Byrareddy S.N. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity. 2020; 109: 102433. DOI: 10.1016/j.jaut.2020.102433.Zhu X., Wang Y., Zhang H. Liu X, Chen T, Yang R, Shi Y, Cao W, Li P, Ma Q, Zhai Y, He F, Zhou G, Cao C. Genetic variation of the human α-2-heremans-schmid glycoprotein (AHSG) gene associated with the risk of SARS-CoV infection. PLoS One. 2011; 6 (8): e23730. DOI: 10.1371/journal.pone.0023730.Zhu X., Wang Y., Zhang H. Liu X, Chen T, Yang R, Shi Y, Cao W, Li P, Ma Q, Zhai Y, He F, Zhou G, Cao C. Genetic variation of the human α-2-heremans-schmid glycoprotein (AHSG) gene associated with the risk of SARS-CoV infection. PLoS One. 2011; 6 (8): e23730. DOI: 10.1371/journal.pone.0023730.Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Временные методические рекомендации: Версия 6 (28.04.2020). М., 2020: 165.Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Временные методические рекомендации: Версия 6 (28.04.2020). М., 2020: 165.Liu J., Zheng X., Tong Q., Li W., Wang B., Sutter K., Trilling M., Lu M., Dittmer U., Yang D. Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. J. Med. Virol. 2020; 92 (5): 491–494. DOI: 10.1002/jmv.25709.Liu J., Zheng X., Tong Q., Li W., Wang B., Sutter K., Trilling M., Lu M., Dittmer U., Yang D. Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. J. Med. Virol. 2020; 92 (5): 491–494. DOI: 10.1002/jmv.25709.Liu Y., Mao B., Liang Sh., Yang J.W., Lu H.W., Chai Y.H., Wang L., Zhang L., Li Q.H., Zhao L., He Y., Gu X.L., Ji X.B., Li L., Jie Z.J., Li Q., Li X.Y., Lu H.Z., Zhang W.H., Song Y.L., Qu J.M., Xu J.F. Association between ages and clinical characteristics and outcomes of coronavirus disease 2019. European Respiratory Journal. 2020; 55 (5): 2001112. DOI: 10.1183/13993003.01112-2020.Liu Y., Mao B., Liang Sh., Yang J.W., Lu H.W., Chai Y.H., Wang L., Zhang L., Li Q.H., Zhao L., He Y., Gu X.L., Ji X.B., Li L., Jie Z.J., Li Q., Li X.Y., Lu H.Z., Zhang W.H., Song Y.L., Qu J.M., Xu J.F. Association between ages and clinical characteristics and outcomes of coronavirus disease 2019. European Respiratory Journal. 2020; 55 (5): 2001112. DOI: 10.1183/13993003.01112-2020.Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X., Liu L., Shan H., Lei C.L., Hui D.S.C., Du B., Li L.J., Zeng G., Yuen K.Y., Chen R.C., Tang C.L., Wang T., Chen P.Y., Xiang J., Li S.Y., Wang J.L., Liang Z.J., Peng Y.X., Wei L., Liu Y., Hu Y.H., Peng P., Wang J.M., Liu J.Y., Chen Z., Li G., Zheng Z.J., Qiu S.Q., Luo J., Ye C.J., Zhu S.Y., Zhong N.S. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 2020; 382 (18): 1708–1720. DOI: 10.1056/NEJMoa2002032.Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X., Liu L., Shan H., Lei C.L., Hui D.S.C., Du B., Li L.J., Zeng G., Yuen K.Y., Chen R.C., Tang C.L., Wang T., Chen P.Y., Xiang J., Li S.Y., Wang J.L., Liang Z.J., Peng Y.X., Wei L., Liu Y., Hu Y.H., Peng P., Wang J.M., Liu J.Y., Chen Z., Li G., Zheng Z.J., Qiu S.Q., Luo J., Ye C.J., Zhu S.Y., Zhong N.S. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 2020; 382 (18): 1708–1720. DOI: 10.1056/NEJMoa2002032.Минздрав РФ. Отчет о работе международной миссии ВОЗ по проблеме COVID-19. URL: https://www.rosminzdrav.ru/news/2020/03/04/13469-predstavlen-otchet-o-rabotemezhdunarodnoy-missii-voz-po-probleme-covid-1924. The novel coronavirus pneumonia emergency response epidemiology team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) – China, 2020. China CDC Weekly. 2020; 2 (8): 113–122.Минздрав РФ. Отчет о работе международной миссии ВОЗ по проблеме COVID-19. URL: https://www.rosminzdrav.ru/news/2020/03/04/13469-predstavlen-otchet-o-rabotemezhdunarodnoy-missii-voz-po-probleme-covid-1924. The novel coronavirus pneumonia emergency response epidemiology team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) – China, 2020. China CDC Weekly. 2020; 2 (8): 113–122.Минздрав РФ. Информация о новой коронавирусной инфекции COVID-19. URL: https://www.rоsmiпzdrаv.ru/Минздрав РФ. Информация о новой коронавирусной инфекции COVID-19. URL: https://www.rоsmiпzdrаv.ru/Никифоров В.В., Суранова Т.Г., Орлова Н.В., Кардонова Е.В., Сметанина С.В. Алгоритмы оказания медицинской помощи больным ОРВИ. Медицинский алфавит. 2019; 27 (402): 6–13. DOI: 10.33667/2078-5631-2019-2-27(402)-6-13.Никифоров В.В., Суранова Т.Г., Орлова Н.В., Кардонова Е.В., Сметанина С.В. Алгоритмы оказания медицинской помощи больным ОРВИ. Медицинский алфавит. 2019; 27 (402): 6–13. DOI: 10.33667/2078-5631-2019-2-27(402)-6-13.Суранова Т.Г. Оценка готовности медицинских организаций по предупреждению заноса и распространения инфекционных болезней, представляющих угрозу возникновения ЧС санитарно-эпидемиологического характера: учеб. пособие для врачей. Серия: Библиотека Всероссийской службы медицины катастроф. М., 2017: 22.Суранова Т.Г. Оценка готовности медицинских организаций по предупреждению заноса и распространения инфекционных болезней, представляющих угрозу возникновения ЧС санитарно-эпидемиологического характера: учеб. пособие для врачей. Серия: Библиотека Всероссийской службы медицины катастроф. М., 2017: 22.Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., Liu S., Zhao P., Liu H., Zhu L., Tai Y., Bai C., Gao T., Song J., Xia P., Dong J., Zhao J., Wang F.S. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020; 8 (4): 420–422. DOI: 10.1016/S2213-2600(20)30076-X.Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., Liu S., Zhao P., Liu H., Zhu L., Tai Y., Bai C., Gao T., Song J., Xia P., Dong J., Zhao J., Wang F.S. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020; 8 (4): 420–422. DOI: 10.1016/S2213-2600(20)30076-X.Meyer N.J., Christie J.D. Genetic heterogeneity and risk of acute respiratory distress syndrome. Semin. Respir. Crit. Care Med. 2013; 34 (4): 459–474. DOI: 10.1055/s-0033-1351121.Meyer N.J., Christie J.D. Genetic heterogeneity and risk of acute respiratory distress syndrome. Semin. Respir. Crit. Care Med. 2013; 34 (4): 459–474. DOI: 10.1055/s-0033-1351121.Thompson B.T., Chambers R.C., Liu K.D. Acute respiratory distress syndrome. N. Engl. J. Med. 2017; 377 (6): 562–572. DOI: 10.1056/NEJMra1608077.Thompson B.T., Chambers R.C., Liu K.D. Acute respiratory distress syndrome. N. Engl. J. Med. 2017; 377 (6): 562–572. DOI: 10.1056/NEJMra1608077.Fu Y., Cheng Y., Wu Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol. Sin. 2020; 35 (3): 266–271. DOI: 10.1007/s12250-020-00207-4.Fu Y., Cheng Y., Wu Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol. Sin. 2020; 35 (3): 266–271. DOI: 10.1007/s12250-020-00207-4.Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X., Liu L., Shan H., Lei C.L., Hui D., Du B., Li L.J., Zeng G., Yuen K.Y., Chen R.C., Tang C.L., Wang T., Chen P.Y., Xiang J., Zhong N.S. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv. 2020; 382 (18): 1708–1720. DOI: 10.1101/2020.02.06.20020974.Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X., Liu L., Shan H., Lei C.L., Hui D., Du B., Li L.J., Zeng G., Yuen K.Y., Chen R.C., Tang C.L., Wang T., Chen P.Y., Xiang J., Zhong N.S. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv. 2020; 382 (18): 1708–1720. DOI: 10.1101/2020.02.06.20020974.Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497–506. DOI: 10.1016/S0140-6736(20)30183-5.Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497–506. DOI: 10.1016/S0140-6736(20)30183-5.Ruan Q., Yang K., Wang W. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan. Intensive Care Med. 2020; 46 (5): 846–848. DOI: 10.1007/s00134-020-05991-x.Ruan Q., Yang K., Wang W. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan. Intensive Care Med. 2020; 46 (5): 846–848. DOI: 10.1007/s00134-020-05991-x.Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., Liu S., Zhao P., Liu H., Zhu L., Tai Y., Bai C., Gao T., Song J., Xia P., Dong J., Zhao J., Wang F.S. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020; 8 (4): 420–422. DOI: 10.1016/S2213-2600(20)30076-X.Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., Liu S., Zhao P., Liu H., Zhu L., Tai Y., Bai C., Gao T., Song J., Xia P., Dong J., Zhao J., Wang F.S. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020; 8 (4): 420–422. DOI: 10.1016/S2213-2600(20)30076-X.Yao X.H., Li T.Y., He Z.C., Ping Y.F., Liu H.W., Yu S.C., Mou H.M., Wang L.H., Zhang H.R., Fu W.J., Luo T., Liu F., Guo Q.N., Chen C., Xiao H.L., Guo H.T., Lin S., Xiang D.F., Shi Y., Pan G.Q., Li Q.R., Huang X., Cui Y., Liu X.Z., Tang W., Pan P.F., Huang X.Q., Ding Y.Q., Bian X.W. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li Xue Za Zhi. 2020; 49 (5): 411–417. DOI: 10.3760/cma.j.cn112151-2020031200193.Yao X.H., Li T.Y., He Z.C., Ping Y.F., Liu H.W., Yu S.C., Mou H.M., Wang L.H., Zhang H.R., Fu W.J., Luo T., Liu F., Guo Q.N., Chen C., Xiao H.L., Guo H.T., Lin S., Xiang D.F., Shi Y., Pan G.Q., Li Q.R., Huang X., Cui Y., Liu X.Z., Tang W., Pan P.F., Huang X.Q., Ding Y.Q., Bian X.W. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li Xue Za Zhi. 2020; 49 (5): 411–417. DOI: 10.3760/cma.j.cn112151-2020031200193.Lei J., Li J., Li X., Qi X. CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology. 2020; 295 (1): 18. DOI: 10.1148/radiol.2020200236.Lei J., Li J., Li X., Qi X. CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology. 2020; 295 (1): 18. DOI: 10.1148/radiol.2020200236.Chen C., Zhou Y., Wang D.W. SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz. 2020; 45 (3): 230–232. DOI: 10.1007/s00059-020-04909-z.Chen C., Zhou Y., Wang D.W. SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz. 2020; 45 (3): 230–232. DOI: 10.1007/s00059-020-04909-z.Yang X., Yu Y., Xu J. Shu H., Xia J., Liu H., Wu Y., Zhang L., Yu Z., Fang M., Yu T., Wang Y., Pan S., Zou X., Yuan S, Shang Y. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 2020; 8 (5): 475–481. DOI: 10.1016/S2213-2600(20)30079-5.Yang X., Yu Y., Xu J. Shu H., Xia J., Liu H., Wu Y., Zhang L., Yu Z., Fang M., Yu T., Wang Y., Pan S., Zou X., Yuan S, Shang Y. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 2020; 8 (5): 475–481. DOI: 10.1016/S2213-2600(20)30079-5.Arentz M., Yim E., Klaff L., Lokhandwala S., Riedo FX., Chong M., Lee M. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington state. JAMA. 2020; 323 (16): 1612–1614. DOI: 10.1001/jama.2020.4326.Arentz M., Yim E., Klaff L., Lokhandwala S., Riedo FX., Chong M., Lee M. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington state. JAMA. 2020; 323 (16): 1612–1614. DOI: 10.1001/jama.2020.4326.Wang D., Hu B., Hu C. Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., Zhao Y., Li Y., Wang X., Peng Z. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323 (11): 1061–1069. DOI: 10.1001/jama.2020.1585.Wang D., Hu B., Hu C. Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., Zhao Y., Li Y., Wang X., Peng Z. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323 (11): 1061–1069. DOI: 10.1001/jama.2020.1585.Hui H., Zhang Y., Yang X., Wang X., He B., Li L., Li H., Tian J., Chen Y. Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia. MedRxiv. 2020; Feb. 27. DOI: 10.1101/2020.02.24.20027052.Hui H., Zhang Y., Yang X., Wang X., He B., Li L., Li H., Tian J., Chen Y. Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia. MedRxiv. 2020; Feb. 27. DOI: 10.1101/2020.02.24.20027052.Du R.-H., Liang L.-R., Yang C.-Q., Wang W., Cao T.Z., Li M., Guo G.Y., Du J., Zheng C.L., Zhu Q., Hu M., Li X.Y., Peng P., Shi H.Z. predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: A Prospective Cohort Study. European Respiratory. 2020; 55 (5): 2000524. DOI: 10.1183/13993003.00524-2020.Du R.-H., Liang L.-R., Yang C.-Q., Wang W., Cao T.Z., Li M., Guo G.Y., Du J., Zheng C.L., Zhu Q., Hu M., Li X.Y., Peng P., Shi H.Z. predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: A Prospective Cohort Study. European Respiratory. 2020; 55 (5): 2000524. DOI: 10.1183/13993003.00524-2020.Chen N., Zhou M., Dong X. Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y., Xia J., Yu T., Zhang X., Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020; 395 (10223): 507–513. DOI: 10.1016/S0140-6736(20)30211-7.Chen N., Zhou M., Dong X. Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y., Xia J., Yu T., Zhang X., Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020; 395 (10223): 507–513. DOI: 10.1016/S0140-6736(20)30211-7.Du Y., Tu L., Zhu P., Mu M., Wang R., Yang P., Wang X., Hu C., Ping R., Hu P., Li T., Cao F., Chang C1., Hu Q., Jin Y., Xu G. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study. Am. J. Respir. Crit. Care Med. 2020; 201 (11): 1372–1379. DOI: 10.1164/rccm.202003-0543OC.Du Y., Tu L., Zhu P., Mu M., Wang R., Yang P., Wang X., Hu C., Ping R., Hu P., Li T., Cao F., Chang C1., Hu Q., Jin Y., Xu G. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study. Am. J. Respir. Crit. Care Med. 2020; 201 (11): 1372–1379. DOI: 10.1164/rccm.202003-0543OC.Liu C., Jiang Z.C., Shao C.X., Zhang H.G., Yue H.M., Chen Z.H., Ma B.Y., Liu W.Y., Huang H.H., Yang J., Wang Y., Liu H.Y., Xu D., Wang J.T., Yang J.Y., Pan H.Q., Zou S.Q., Li F.J., Lei J.Q., Li X., He Q., Gu Y., Qi X.L. Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study. Zhonghua Gan Zang Bing Za Zhi. 2020; 28 (2): 107–111. DOI: 10.3760/cma.j.issn.1007-3418.2020.02.003.Liu C., Jiang Z.C., Shao C.X., Zhang H.G., Yue H.M., Chen Z.H., Ma B.Y., Liu W.Y., Huang H.H., Yang J., Wang Y., Liu H.Y., Xu D., Wang J.T., Yang J.Y., Pan H.Q., Zou S.Q., Li F.J., Lei J.Q., Li X., He Q., Gu Y., Qi X.L. Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study. Zhonghua Gan Zang Bing Za Zhi. 2020; 28 (2): 107–111. DOI: 10.3760/cma.j.issn.1007-3418.2020.02.003.Lu H., Ai J., Shen Y., Li Y., Li T., Zhou X., Zhang H., Zhang Q., Ling Y., Wang, S., Qu H., Ga, Y., Li Y., Yu K., Zhu D., Zhu H., Tian R., Zeng M., Li Q., Zhang W. A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention. MedRxiv. 2020; Feb. 27. DOI: 10.1101/2020.02.19.20025031.Lu H., Ai J., Shen Y., Li Y., Li T., Zhou X., Zhang H., Zhang Q., Ling Y., Wang, S., Qu H., Ga, Y., Li Y., Yu K., Zhu D., Zhu H., Tian R., Zeng M., Li Q., Zhang W. A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention. MedRxiv. 2020; Feb. 27. DOI: 10.1101/2020.02.19.20025031.Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S., Huang H., Zhang L., Zhou X., Du C., Zhang Y., Song J., Wang S., Chao Y., Yang Z., Xu J., Zhou X., Chen D., Xiong W., Xu L., Zhou F., Jiang J., Bai C., Zheng J., Song Y. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern. Med. 2020; 180 (7): 934–943. DOI: 10.1001/jamainternmed.2020.0994.Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S., Huang H., Zhang L., Zhou X., Du C., Zhang Y., Song J., Wang S., Chao Y., Yang Z., Xu J., Zhou X., Chen D., Xiong W., Xu L., Zhou F., Jiang J., Bai C., Zheng J., Song Y. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern. Med. 2020; 180 (7): 934–943. DOI: 10.1001/jamainternmed.2020.0994.Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., Guan L., Wei Y., Li H., Wu X., Xu J., Tu S., Zhang Y., Chen H., Cao B. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395 (10229): 1054–1062. DOI: 10.1016/S0140-6736(20)30566-3.Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., Guan L., Wei Y., Li H., Wu X., Xu J., Tu S., Zhang Y., Chen H., Cao B. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395 (10229): 1054–1062. DOI: 10.1016/S0140-6736(20)30566-3.Tang N., Li D., Wang X., Sun Z. Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J. Thromb. Haemost. 2020; 18 (4): 844–847. DOI: 10.1111/jth.14768.Tang N., Li D., Wang X., Sun Z. Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J. Thromb. Haemost. 2020; 18 (4): 844–847. DOI: 10.1111/jth.14768.Ciceri F., Beretta L., Scandroglio A.M., Colombo S., Landoni G., Ruggeri A., Peccatori J., D’Angelo A., De Cobelli F., Rovere-Querini P., Tresoldi M., Dagna L., Zangrillo A. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit. Care Resusc. 2020; 22 (2): 95–97.Ciceri F., Beretta L., Scandroglio A.M., Colombo S., Landoni G., Ruggeri A., Peccatori J., D’Angelo A., De Cobelli F., Rovere-Querini P., Tresoldi M., Dagna L., Zangrillo A. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit. Care Resusc. 2020; 22 (2): 95–97.Kollias A., Kyriakoulis K.G., Dimakakos E., Poulakou G., Stergiou G.S., Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID-19 patients: Emerging evidence and call for action. Br. J. Haematol. 2020; 189 (5): 846–847. DOI: 10.1111/bjh.16727.Kollias A., Kyriakoulis K.G., Dimakakos E., Poulakou G., Stergiou G.S., Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID-19 patients: Emerging evidence and call for action. Br. J. Haematol. 2020; 189 (5): 846–847. DOI: 10.1111/bjh.16727.Spyropoulos A.C., Ageno W., Barnathan E.S. Hospital-based use of thromboprophylaxis in patients with COVID-19. Lancet. 2020; 395 (10234): e75. DOI: 10.1016/S0140-6736(20)30926-0.Spyropoulos A.C., Ageno W., Barnathan E.S. Hospital-based use of thromboprophylaxis in patients with COVID-19. Lancet. 2020; 395 (10234): e75. DOI: 10.1016/S0140-6736(20)30926-0.Lin M., Tseng H.K., Trejaut J.A., Lee H.L., Loo J.H., Chu C.C., Chen P.J., Su Y.W., Lim K.H., Tsai Z.U., Lin R.Y., Lin R.S., Huang C.H. Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Med. Genet. 2003; 4: 9. DOI: 10.1186/1471-2350-4-9.Lin M., Tseng H.K., Trejaut J.A., Lee H.L., Loo J.H., Chu C.C., Chen P.J., Su Y.W., Lim K.H., Tsai Z.U., Lin R.Y., Lin R.S., Huang C.H. Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Med. Genet. 2003; 4: 9. DOI: 10.1186/1471-2350-4-9.Nguyen A., David J.K., Maden S.K., Wood M.A., Weeder B.R., Nellore A., Thompson R.F. Human leukocyte antigen susceptibility map for SARS-CoV-2. Journal of Virology. 2020; 94 (13): e00510–00520. DOI: 10.1128/JVI.00510-20.Nguyen A., David J.K., Maden S.K., Wood M.A., Weeder B.R., Nellore A., Thompson R.F. Human leukocyte antigen susceptibility map for SARS-CoV-2. Journal of Virology. 2020; 94 (13): e00510–00520. DOI: 10.1128/JVI.00510-20.Li X., Geng M., Peng Y., Meng L., Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis. 2020; 10 (2): 102–108. DOI: 10.1016/j.jpha.2020.03.001.Li X., Geng M., Peng Y., Meng L., Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis. 2020; 10 (2): 102–108. DOI: 10.1016/j.jpha.2020.03.001.Jiang X., Coffee M., Bari A., et al. Towards an artificial intelligence framework for data-driven prediction of coronavirus clinical severity. CMC-Computers, Materials & Continua. 2020; 63 (1); 537–551. DOI: 10.32604/cmc.2020.010691.Jiang X., Coffee M., Bari A., et al. Towards an artificial intelligence framework for data-driven prediction of coronavirus clinical severity. CMC-Computers, Materials & Continua. 2020; 63 (1); 537–551. DOI: 10.32604/cmc.2020.010691.Gong J., Ou J., Qiu X., Jie Y., Chen Y., Yuan L., Cao J., Tan M., Xu W., Zheng F., Shi Y. & Hu B. A Tool to early predict severe 2019-novel coronavirus pneumonia (COVID-19): A Multicenter Study using the risk nomogram in Wuhan and Guangdong, China. MedRxiv. 2020 Apr. 22. DOI: 10.1101/2020.03.17.20037515.Gong J., Ou J., Qiu X., Jie Y., Chen Y., Yuan L., Cao J., Tan M., Xu W., Zheng F., Shi Y. & Hu B. A Tool to early predict severe 2019-novel coronavirus pneumonia (COVID-19): A Multicenter Study using the risk nomogram in Wuhan and Guangdong, China. MedRxiv. 2020 Apr. 22. DOI: 10.1101/2020.03.17.20037515.Mitra A., Dwyre D.M., Schivo M., Thompson G.R., Cohen S.H., Ku N., Graff J.P. Leukoerythroblastic reaction in a patient with COVID-19 infection. Am. J. Hematol. 2020; 95 (8): 999–1000. DOI: 10.1002/ajh.25793.Mitra A., Dwyre D.M., Schivo M., Thompson G.R., Cohen S.H., Ku N., Graff J.P. Leukoerythroblastic reaction in a patient with COVID-19 infection. Am. J. Hematol. 2020; 95 (8): 999–1000. DOI: 10.1002/ajh.25793.Sassa S. Modern diagnosis and management of the porphyrias. British Journal of Haematology. 2006; 135 (2): 281–292. DOI: 10.1111/j.1365.2141.2006.06289.x.Sassa S. Modern diagnosis and management of the porphyrias. British Journal of Haematology. 2006; 135 (2): 281–292. DOI: 10.1111/j.1365.2141.2006.06289.x.Abrahams L. Covid-19: acquired acute porphyria hypothesis.OSF Preprints. 2020; Apr. DOI: 10.31219/osf.io/4wkfy.Abrahams L. Covid-19: acquired acute porphyria hypothesis.OSF Preprints. 2020; Apr. DOI: 10.31219/osf.io/4wkfy.Wenzhong L., Hualan Li. COVID-19: attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism. ChemRxiv. 2020 July 12. DOI: 10.26434/chemrxiv.11938173.v5.Wenzhong L., Hualan Li. COVID-19: attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism. ChemRxiv. 2020 July 12. DOI: 10.26434/chemrxiv.11938173.v5.Lippi G., Plebani M., Henry B.M. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin. Chim. Acta. 2020; 506: 145–148. DOI: 10.1016/j.cca.2020.03.022Lippi G., Plebani M., Henry B.M. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin. Chim. Acta. 2020; 506: 145–148. DOI: 10.1016/j.cca.2020.03.022Varga Z., Flammer J., Steiger P., Haberecker M., Andermatt R., Zinkernagel S. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020; 395 (10234): 1417–1418. DOI: 10.1016 / S0140-6736 (20)30937-5.Varga Z., Flammer J., Steiger P., Haberecker M., Andermatt R., Zinkernagel S. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020; 395 (10234): 1417–1418. DOI: 10.1016 / S0140-6736 (20)30937-5.Zhang Y., Qin L., Zhao Y., Zhang P., Xu B., Li K., Liang L., Zhang C., Dai Y., Feng Y., Sun J., Hu Z., Xiang H., Knight J.C., Dong T., Jin R. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19. The Journal of Infectious Diseases. 2020; 222 (1): 34–37. DOI: 10.1093/infdis/jiaa224.Zhang Y., Qin L., Zhao Y., Zhang P., Xu B., Li K., Liang L., Zhang C., Dai Y., Feng Y., Sun J., Hu Z., Xiang H., Knight J.C., Dong T., Jin R. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19. The Journal of Infectious Diseases. 2020; 222 (1): 34–37. DOI: 10.1093/infdis/jiaa224.Asselta R., Paraboschi E.M., Mantovani A. Duga S. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. MedRxiv. 2020; 12 (11): 10087–10098. DOI: 10.18632/aging.103415.Asselta R., Paraboschi E.M., Mantovani A. Duga S. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. MedRxiv. 2020; 12 (11): 10087–10098. DOI: 10.18632/aging.103415.Borie R., Le Guen Р., Ghanem M., Taillé C., Dupin C., Dieudé P., Kannengiesser C., Crestani B. The genetics of interstitial lung diseases. Eur. Respir. Rev. 2019; 28 (153): 190053. DOI: 10.1183/16000617.0053-2019.Borie R., Le Guen Р., Ghanem M., Taillé C., Dupin C., Dieudé P., Kannengiesser C., Crestani B. The genetics of interstitial lung diseases. Eur. Respir. Rev. 2019; 28 (153): 190053. DOI: 10.1183/16000617.0053-2019.Darbani B. The expression and polymorphism of entry machinery for COVID-19 inhuman: juxtaposing population groups, gender, and different issues. Preprints. 2020; 17 (10): 3433. DOI: 10.3390/ijerph17103433.Darbani B. The expression and polymorphism of entry machinery for COVID-19 inhuman: juxtaposing population groups, gender, and different issues. Preprints. 2020; 17 (10): 3433. DOI: 10.3390/ijerph17103433.Wu Z., Mc Googan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 2020 Feb. 24.Wu Z., Mc Googan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 2020 Feb. 24.Zhu N., Zhang D., Wang W., Li X., Yang B., Song J. Zhao X., Huang B., Shi W., Lu R., Niu P., Zhan F., Ma X., Wang D., Xu W., Wu G., Gao G.F., Tan W. China novel coronavirus investigating and research team. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020; 382 (8): 727–733. DOI: 10.1056/NEJMoa2001017.Zhu N., Zhang D., Wang W., Li X., Yang B., Song J. Zhao X., Huang B., Shi W., Lu R., Niu P., Zhan F., Ma X., Wang D., Xu W., Wu G., Gao G.F., Tan W. China novel coronavirus investigating and research team. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020; 382 (8): 727–733. DOI: 10.1056/NEJMoa2001017.Berghofer B., Frommer T., Haley G., Fink L., Bein G., Hackstein H. TLR7 ligands induce higher IFN-alpha production in females. J. Immunol. 2006; 177 (4): 2088–2096. DOI: 10.4049/jimmunol.177.4.2088.Berghofer B., Frommer T., Haley G., Fink L., Bein G., Hackstein H. TLR7 ligands induce higher IFN-alpha production in females. J. Immunol. 2006; 177 (4): 2088–2096. DOI: 10.4049/jimmunol.177.4.2088.Karlberg J., Chong D.S., Lai W.Y. Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? Am. J. Epidemiol. 2004; 159 (3): 229–231. DOI: 10.1093/aje/kwh056.Karlberg J., Chong D.S., Lai W.Y. Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? Am. J. Epidemiol. 2004; 159 (3): 229–231. DOI: 10.1093/aje/kwh056.Meier A., Chang J.J., Chan E.S., Pollard R.B., Sidhu H.K., Kulkarni S., Wen T.F., Lindsay R.J., Orellana L., Mildvan D., Bazner S., Streeck H., Alter G., Lifson J.D., Carrington M., Bosch R.J., Robbins G.K., Altfeld M. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat. Med. 2009; 15 (8): 955–959. DOI: 10.1038/nm.2004.Meier A., Chang J.J., Chan E.S., Pollard R.B., Sidhu H.K., Kulkarni S., Wen T.F., Lindsay R.J., Orellana L., Mildvan D., Bazner S., Streeck H., Alter G., Lifson J.D., Carrington M., Bosch R.J., Robbins G.K., Altfeld M. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat. Med. 2009; 15 (8): 955–959. DOI: 10.1038/nm.2004.Egli A., Santer D.M., O’Shea D., Tyrrell D.L., Houghton M. The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections. Emerg. Microbes. Infect. 2014; 3 (7): e51. DOI: 10.1038/emi.2014.51.Egli A., Santer D.M., O’Shea D., Tyrrell D.L., Houghton M. The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections. Emerg. Microbes. Infect. 2014; 3 (7): e51. DOI: 10.1038/emi.2014.51.Prokunina-Olsson L., Muchmore B., Tang W., Pfeiffer R.M., Park H., Dickensheets H., Hergott D., Porter-Gill P., Mumy A., Kohaar I., Chen S., Brand N., Tarway M., Liu L., Sheikh F., Astemborski J., Bonkovsky H.L., Edlin B.R., Howell C.D., Morgan T.R., Thomas D.L., Rehermann B., Donnelly R.P., O’Brien T.R. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat. Genet. 2013; 45 (2): 164–171. DOI: 10.1038/ng.2521.Prokunina-Olsson L., Muchmore B., Tang W., Pfeiffer R.M., Park H., Dickensheets H., Hergott D., Porter-Gill P., Mumy A., Kohaar I., Chen S., Brand N., Tarway M., Liu L., Sheikh F., Astemborski J., Bonkovsky H.L., Edlin B.R., Howell C.D., Morgan T.R., Thomas D.L., Rehermann B., Donnelly R.P., O’Brien T.R. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat. Genet. 2013; 45 (2): 164–171. DOI: 10.1038/ng.2521.Mihm S. Activation of type i and type III interferons in chronic hepatitis C. J. Innate Immun. 2015; 7 (3): 251–259. DOI:Mihm S. Activation of type i and type III interferons in chronic hepatitis C. J. Innate Immun. 2015; 7 (3): 251–259. DOI:1159/000369973.1159/000369973.Li X., Wang L., Yan S. Yang F., Xiang L., Zhu J., Shen B., Gong Z. Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan. China. Int. J. Infect. Dis. 2020; 94: 1284– 132. DOI: 10.1016/j.ijid.2020.03.053.Li X., Wang L., Yan S. Yang F., Xiang L., Zhu J., Shen B., Gong Z. Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan. China. Int. J. Infect. Dis. 2020; 94: 1284– 132. DOI: 10.1016/j.ijid.2020.03.053.-Zhang C., Shi L., Wang F.S. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol. Hepatol. 2020; 5 (5): 428–430. DOI: 10.1016/S2468-1253(20)30057-1.-Zhang C., Shi L., Wang F.S. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol. Hepatol. 2020; 5 (5): 428–430. DOI: 10.1016/S2468-1253(20)30057-1.

The authors declare that there are no conflicts of interest present.