ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2021-2-160-167ssmu-4393Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРоль убиквитин-протеасомной системы в развитии плоскоклеточного рака полости ртаRole of the ubiquitin-proteasome system in the progression of oral squamous cell carcinomahttps://orcid.org/0000-0002-5899-3872МихалевД. Е.MikhalevD. E.

 аспирант, кафедра стоматологии

Россия, 634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050, Russian Federation

dm199412@gmail.comhttps://orcid.org/0000-0002-4748-4175БайдикО. Д.BaydikO. D.

 д-р мед. наук, профессор, зав. кафедрой стоматологии

Россия, 634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050, Russian Federation

https://orcid.org/0000-0002-0947-8778КондаковаИ. В.KondakovaI. V.

 д-р мед. наук, профессор, зав. лабораторией биохимии опухолей

Россия, 634050, г. Томск, пер. Кооперативный, 5

5, Kooperativny Str., Tomsk, 634050, Russian Federation

https://orcid.org/0000-0001-5838-9459СиденкоЕ. А.SidenkoE. A.

 аспирант, лаборатория биохимии опухолей

Россия, 634050, г. Томск, пер. Кооперативный, 5

5, Kooperativny Str., Tomsk, 634050, Russian Federation

https://orcid.org/0000-0003-1555-050XМухамедовМ. Р.MukhamedovM. R.

 д-р мед. наук, вед. науч. сотрудник, отделение опухолей головы и шеи 

Россия, 634050, г. Томск, пер. Кооперативный, 5

5, Kooperativny Str., Tomsk, 634050, Russian Federation

https://orcid.org/0000-0002-4045-2664СысолятинП. Г.SysolyatinP. G.

 д-р мед. наук, профессор, заслуженный деятель науки Российской Федерации, кафедра госпитальной хирургической стоматологии и челюстно-лицевой хирургии

Россия, 630091, г. Новосибирск, Красный пр., 52

52, Krasny Av., Novosibirsk, 630091, Russian Federation

Сибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical University (SSMU)Russian FederationНаучно-исследовательский институт (НИИ) онкологии, Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукРоссияCancer Research Institute, Tomsk National Research Medical Center (TNRМС) of the Russian Academy of ScienceRussian FederationНовосибирский государственный медицинский университет (НГМУ)РоссияNovosibirsk State Medical University (NSMU)Russian Federation202117072021202160167Copyright © Михалев Д.Е., Байдик О.Д., Кондакова И.В., Сиденко Е.А., Мухамедов М.Р., Сысолятин П.Г., 20212021Михалев Д.Е., Байдик О.Д., Кондакова И.В., Сиденко Е.А., Мухамедов М.Р., Сысолятин П.Г.Mikhalev D.E., Baydik O.D., Kondakova I.V., Sidenko E.A., Mukhamedov M.R., Sysolyatin P.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/4393

 Убиквитин-протеасомная система контролирует активность, субклеточную локализацию и стабильность множества клеточных белков, которые влияют на клеточный гомеостаз посредством регуляции сигнальных каскадов. Активность данной системы связана с возникновением и  прогрессированием плоскоклеточного рака полости рта, так как специфический протеолиз большинства  внутриклеточных протеинов, участвующих в патогенезе рака, происходит с помощью вышеупомянутой системы.В обзорной статье представлены данные о характеристике  протеасом и процессе убиквинтирования белковсубстратов. Показана роль убиквитин-протеасомной системы в  патогенезе плоскоклеточного рака полости рта, приведены сведения о перспективах использования ее при предраке. Поиск литературы осуществлялся в поисковых системах Medline, Elibrary, Scopus, The Cochrane Library, РИНЦ.  

 The ubiquitin-proteasome system (UPS) controls the activity, subcellular localization, and stability of many cellular proteins that affect cellular homeostasis by regulating multiple signaling cascades. The activity of this system is associated with the emergence and progression of oral squamous cell carcinoma, since specific proteolysis of most intracellular proteins involved in the pathogenesis of cancer is implemented by this system.The review article presents data on the characteristics of proteasomes and the process of substrate protein ubiquitination. The role of the ubiquitin-proteasome system in the pathogenesis of oral squamous cell carcinoma is shown, and the prospects of its use in precancerous diseases are described. The  literature search was carried out in the search engines Medline, eLIBRARY, Scopus, The Cochrane Library, and RSCI. 

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The authors declare that there are no conflicts of interest present.