References

ssmu

Бюллетень сибирской медицины

Bulletin of Siberian Medicine

1682-03631819-3684

Siberian State Medical University, the Ministry of Healthcare of the Russian Federation

10.20538/1682-0363-2021-3-161-167

ssmu-4493

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEW AND LECTURES

Диагностические маркеры локального аллергического ринита

Diagnostic markers of local allergic rhinitis

https://orcid.org/0000-0002-2776-5834

Климов

А. В.

Klimov

A. V.

канд. мед. наук, доцент, кафедра оториноларингологии, иммунологии и аллергологии

Россия, 634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050, Russian Federation

klimov.lor@mail.ru

https://orcid.org/0000-0001-6673-7556

Климов

В. В.

Klimov

V. V.

д-р мед. наук, зав. кафедрой оториноларингологии, иммунологии и аллергологии

Россия, 634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050, Russian Federation

https://orcid.org/0000-0002-8298-7456

Koваль

С. А.

Koval

S. A.

ассистент, кафедра оториноларингологии, иммунологии и аллергологии

Россия, 634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050, Russian Federation

https://orcid.org/0000-0001-7594-6800

Свиридова

В. С.

Sviridova

V. S.

канд. мед. наук, доцент, кафедра иммунологии и аллергологии

Россия, 634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050, Russian Federation

https://orcid.org/0000-0002-6032-2402

Koшкарова

Н. С.

Koshkarova

N. S.

канд. мед. наук, доцент, кафедра иммунологии и аллергологии

Россия, 634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050, Russian Federation

Сибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical UniversityRussian Federation

2021

21102021

203161167

2021

Климов А.В., Климов В.В., Koваль С.А., Свиридова В.С., Koшкарова Н.С.

Klimov A.V., Klimov V.V., Koval S.A., Sviridova V.S., Koshkarova N.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://bulletin.ssmu.ru/jour/article/view/4493

Локальный аллергический ринит является новой атопической болезнью в современной аллергологии и ринологии. Его клинические симптомы в настоящее время хорошо описаны с проведением сравнения с классическим аллергическим ринитом, но диагностические и терапевтические протоколы, включая аллерген-специфическую иммунотерапию, еще уточняются.Таким образом, локальный аллергический ринит остается недостаточно диагностированной патологией и по ошибке часто относится к группе неаллергических ринитов. Однако патогенез и особенно механизмы срыва аллергенной толерантности при этом эндотипе аллергического ринита остаются неизученными.Продолжаются исследования сети протолерогенных клеток и молекул, включая Т-регуляторные клетки, протолерогенные дендритные клетки, интерлейкин (IL)-10, IL-35, трансформирующий фактор роста b, вегетативную иннервацию носа и нейротрансмиттеры. Цель настоящего обзора сфокусирована на диагностических маркерах локального аллергического ринита.

Local allergic rhinitis is a new atopic disease recognized in modern allergy and rhinology. Its clinical symptoms are currently well described and compared with conventional allergic rhinitis, however, diagnostic and therapeutic protocols, including antigen-specific immunotherapy (ASIT), should be specified.

Therefore, local allergic rhinitis often remains underdiagnosed and by mistake is referred to non-allergic rhinitis. Yet, the pathogenesis and mechanisms of allergen tolerance breakdown in this endotype of allergic rhinitis remain understudied. Researchers continue to study the network of tolerogenic cells and biomolecules, such as regulatory T cells, tolerogenic dendritic cells, interleukin (IL)-10, IL-35, transforming growth factor-β (TGF-b), vegetative innervation of the nose, and neurotransmitters.

The review focuses on diagnostic markers of local allergic rhinitis.

локальный аллергический ринитвидеориноскопияназальный провокационный тестспецифические назальные иммуноглобулинытест активации базофилов

local allergic rhinitisnasal endoscopynasal allergen provocation testnasal specific IgEbasophil activation test

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The authors declare that there are no conflicts of interest present.