ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2021-4-39-48ssmu-4578Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSРаспространенность заболеваний и патологических состояний у молодых людей до 45 лет с абдоминальным ожирением в СибириPrevalence of diseases and pathological conditions in young people under 45 years of age with abdominal obesity in Siberiahttps://orcid.org/0000-0002-4936-8362РагиноЮ. И.RaginoYu. I.

д-р мед. наук, профессор, чл.-корр. РАН, руководитель, 

630089, г. Новосибирск, ул. Б. Богаткова, 175/1

175/1, B. Bogatkova Str., Novosibirsk, 630089

https://orcid.org/0000-0001-7875-1566ХудяковаА. Д.KhudyakovaA. D.

канд. мед. наук, зав. лабораторией генетических и средовых детерминант жизненного цикла человека, 

630089, г. Новосибирск, ул. Б. Богаткова, 175/1

175/1, B. Bogatkova Str., Novosibirsk, 630089

https://orcid.org/0000-0001-5316-4664СтрюковаЕ. В.StriukovaE. V.

мл. науч. сотрудник, лаборатория генетических и средовых детерминант жизненного цикла человека, 

630089, г. Новосибирск, ул. Б. Богаткова, 175/1

175/1, B. Bogatkova Str., Novosibirsk, 630089

stryukova.j@mail.ruhttps://orcid.org/0000-0002-2470-2133ДенисоваД. В.DenisovaD. V.

д-р мед. наук, вед. науч. сотрудник, лаборатория профилактической медицины, 

630089, г. Новосибирск, ул. Б. Богаткова, 175/1

175/1, B. Bogatkova Str., Novosibirsk, 630089

https://orcid.org/0000-0001-9270-9188ЩербаковаЛ. В.ShcherbakovaL. V.

ст. науч. сотрудник, лаборатория клинико-популяционных и профилактических исследований терапевтических и эндокринных заболеваний, 

630089, г. Новосибирск, ул. Б. Богаткова, 175/1

175/1, B. Bogatkova Str., Novosibirsk, 630089

Научно-исследовательский институт терапии и профилактической медицины – филиал Федерального исследовательского центра «Институт цитологии и генетики Сибирского отделения Российской академии наук» (НИИТПМ – филиал ИЦиГ СО РАН)РоссияResearch Institute of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)Russian Federation2021010120222043948Copyright © Рагино Ю.И., Худякова А.Д., Стрюкова Е.В., Денисова Д.В., Щербакова Л.В., 20222022Рагино Ю.И., Худякова А.Д., Стрюкова Е.В., Денисова Д.В., Щербакова Л.В.Ragino Y.I., Khudyakova A.D., Striukova E.V., Denisova D.V., Shcherbakova L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/4578

Цель – изучение распространенности абдоминального ожирения (АО) в популяции молодых людей 25– 44 лет г. Новосибирска, а также распространенности терапевтических заболеваний и патологических состояний у лиц с АО.

Материалы и методы

Материалы и методы. Проведено одномоментное популяционное обследование населения 25–44 лет г. Новосибирска. На скрининге обследованы 1 415 человек, из них 670 мужчин (47,3%) и 745 женщин (52,7%). Беременные и женщины в декретном отпуске не включались в исследование. У обследуемых оценивалось наличие таких заболеваний и патологических состояний, как АО, артериальная гипертензия (АГ), повышенный индекс массы тела, ишемическая болезнь сердца (по валидизированным эпидемиологическим и функциональным критериям с расшифровкой электрокардиограммы по Миннесотскому коду), сахарный диабет (СД), сниженная скорость клубочковой фильтрации (СКФ), хронический бронхит (ХБ), повышенный уровень в крови общего ХС (гиперХСемия), повышенный уровень в крови ХС-ЛНП (гиперХС-ЛНПемия).

Результаты

Результаты. Распространенность АО в популяции 25–44 лет г. Новосибирска составила 42,4%, у мужчин – 42,7%, у женщин – 42,1%. Обнаружено, что в молодой популяции до 45 лет АО оказывает прямое влияние на развитие АГ (отношение шансов (ОШ) 2,550, 95%-й доверительный интервал (95%-й ДИ) 1,899–3,422, р = 0,0001), ХБ (ОШ = 1,830, 95%-й ДИ 1,326–2,527, р = 0,0001), гиперХСемии (ОШ = 1,486, 95%-й ДИ 1,193–1,851, р = 0,0001), гипер-ХС-ЛНПемии (ОШ = 1,527, 95%-й ДИ 1,222–1,907, р = 0,0001), обратное влияние на развитие сниженной СКФ (ОШ = 0,603, 95%-й ДИ 0,427–0,852, р = 0,004). В мужской популяции до 45 лет АО оказывает прямое влияние на развитие АГ, ХБ, гиперХСемии, гипер-ХС-ЛНПемии. В женской популяции до 45 лет АО оказывает прямое влияние на развитие СД, АГ, ХБ, гипер-ХС-ЛНПемии, и обратное – на развитие сниженной СКФ.

Заключение

Заключение. Таким образом, в популяции до 45 лет абдоминальное ожирение ассоциировано с развитием распространенных терапевтических заболеваний и патологических состояний. 

Aim

Aim. To study the prevalence of abdominal obesity in young people aged 25–44 years in Novosibirsk, as well as the prevalence of diseases and pathological conditions in individuals with abdominal obesity.

Materials and methods

Materials and methods. We conducted a cross-sectional, population-based study of the population of Novosibirsk aged 25–44 years. The screening examined 1,415 people, including 670 men and 745 women. For all individuals, we evaluated the presence of such conditions as abdominal obesity (AO), arterial hypertension (AH), increased body mass index (BMI), coronary heart disease (according to validated epidemiologic and functional criteria with ECG findings classified according to the Minnesota Code), diabetes mellitus (DM), reduced glomerular filtration rate (GFR), chronic bronchitis (CB), increased blood levels of total cholesterol (hypercholesterolemia) and lowdensity lipoprotein (LDL) cholesterol (hyper-LDL-cholesterolemia).

Results

Results. The prevalence of AO in the population of Novosibirsk aged 25–44 years was 42.4%: in men – 42.7%, in women – 42.1%. We found that AO had a significant direct effect on the development of AH (odds ratio (OR) = 2.550, 95% confidence interval (CI) 1.899–3.422, p = 0.0001), CB (OR = 1.830, CI 1.326–2.527, p = 0.0001), hypercholesterolemia (OR = 1.486, CI 1.193–1.851, p = 0.0001), hyper-LDL-cholesterolemia (OR = 1.527, CI 1.222–1.907, p = 0.0001) and a reverse effect on reduced GFR (OR = 0.603, CI 0.427–0.852, p = 0.004). In the male population under 45 years of age, AO had a significant direct effect on the development of AH, CB, hypercholesterolemia, and hyper-LDL-cholesterolemia. In the female population under the age of 45, AO had a significant direct effect on the development of DM, AH, CB, and hyper-LDL-cholesterolemia and a reverse effect on the reduced GFR development.

Conclusion

Conclusion. Therefore, in the young Siberian population under 45 years of age, abdominal obesity is associated with the development of common diseases and pathological conditions. 

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The authors declare that there are no conflicts of interest present.