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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2021-4-112-122</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-4588</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Приверженность модификации образа жизни при неалкогольной жировой болезни печени</article-title><trans-title-group xml:lang="en"><trans-title>Adherence to lifestyle modification in patients with nonalcoholic fatty liver disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9976-573X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреев</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreev</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>инспектор, управление по развитию регионального здравоохранения и медицинской деятельности, </p><p>644099, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenina Str., Omsk, 644099</p></bio><email xlink:type="simple">kivi2104@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6225-2444</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скирденко</surname><given-names>Ю. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Skirdenko</surname><given-names>Yu. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры факультетской терапии и гастроэнтерологии,</p><p>644099, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenina Str., Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3758-4930</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, доцент, профессор кафедры факультетской терапии и гастроэнтерологии, проректор по медицинской деятельности и региональному здравоохранению, </p><p>644099, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenina Str., Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6581-7017</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ливзан</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Livzan</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, зав. кафедрой факультетской терапии и гастроэнтерологии, ректор,</p><p>644099, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenina Str., Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9703-9371</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбенко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>инспектор, управление по развитию регионального здравоохранения и медицинской деятельности, </p><p>644099, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenina Str., Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0238-4664</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федорин</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorin</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>инспектор, управление по развитию регионального здравоохранения и медицинской деятельности, </p><p>644099, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenina Str., Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7452-7230</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кролевец</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Krolevets</surname><given-names>T. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры факультетской терапии и гастроэнтерологии, </p><p>644099, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenina Str., Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Омский государственный медицинский университет (ОмГМУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>03</day><month>01</month><year>2022</year></pub-date><volume>20</volume><issue>4</issue><fpage>112</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Андреев К.А., Скирденко Ю.П., Николаев Н.А., Ливзан М.А., Горбенко А.В., Федорин М.М., Кролевец Т.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Андреев К.А., Скирденко Ю.П., Николаев Н.А., Ливзан М.А., Горбенко А.В., Федорин М.М., Кролевец Т.С.</copyright-holder><copyright-holder xml:lang="en">Andreev K.A., Skirdenko Y.P., Nikolaev N.A., Livzan M.A., Gorbenko A.V., Fedorin M.M., Krolevets T.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/4588">https://bulletin.ssmu.ru/jour/article/view/4588</self-uri><abstract><p>Неалкогольная жировая болезнь печени (НАЖБП) вносит серьезный вклад в заболеваемость и смертность трудоспособного населения развитых стран. При отсутствии эффективных фармакологических подходов ведущую роль в лечении НАЖБП играет модификация образа жизни, в первую очередь последовательная и постепенная потеря массы тела, а также ее поддержание. Качественный и количественный состав диеты, уровень физической активности, а главное, регулярность выполнения мероприятий по модификации образа жизни являются залогом успешного ведения пациентов с НАЖБП.</p><p>На сегодняшний день исследований, посвященных изучению вопросов приверженности мероприятиям по изменению образа жизни у данной группы больных, крайне мало, что во многом связано со скудностью методологического инструментария. Рекомендованный российским научным медицинским обществом терапевтов опросник количественной оценки приверженности лечению «КОП-25» позволяет оценить как приверженность терапии в целом, так и по отдельным ключевым компонентам (приверженность лекарственной терапии, приверженность медицинскому сопровождению и приверженность модификации образа жизни), что требует изучения, учитывая особенности терапевтических стратегий при НАЖБП. </p></abstract><trans-abstract xml:lang="en"><p>Nonalcoholic fatty liver disease (NAFLD) makes a major impact on morbidity and mortality among the workingage population in developed countries. In the lack of effective pharmacological methods, the leading role in treatment of NAFLD belongs to lifestyle modification, consistent and gradual weight loss, and its maintenance. The qualitative and quantitative structure of the diet, intensity of physical activity, and most importantly, regularity and consistency of implementation of lifestyle modification activities are the key to successful management of patients with NAFLD.</p><p>To date, there are very few studies on adherence to lifestyle modification activities in this group of patients, which is mainly due to a deficiency of methodological tools. The questionnaire “QAA-25” recommended by the Russian Scientific Medical Society of Therapists for quantitative assessment of adherence to treatment allows to assess both adherence to therapy in general and adherence to its individual components (adherence to drug therapy, adherence to medical counseling, and adherence to lifestyle modification), which requires further study taking into account features of therapeutic strategies in treating NAFLD. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>неалкогольная жировая болезнь печени</kwd><kwd>приверженность</kwd><kwd>модификация образа жизни</kwd><kwd>инсулинорезистентность</kwd><kwd>метаболический синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nonalcoholic fatty liver disease</kwd><kwd>lifestyle modification</kwd><kwd>adherence</kwd><kwd>insulin resistance</kwd><kwd>metabolic syndrome</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация подготовлена за счет финансирования по гранту Президента России для государственной поддержки ведущих научных школ НШ-2558.2020.7 (соглашение № 075-15- 2020-036 от 17.03.2020) «Разработка технологии здоровьесбережения коморбидного больного гастроэнтерологического профиля на основе контроля приверженности»</funding-statement><funding-statement xml:lang="en">The study was supported by the grant of the President of the Russian Federation for the state support for the leading scientific schools of the Russian Federation SS-2558.2020.7 (Agreement No. 075-15-2020- 036 of 17.03.2020) “Development of Health-Preserving Technology for a Comorbid Gastroenterological Patient Based on Adherence Control”.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Byrne C.D., Targher G. 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