<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2021-4-193-204</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-4596</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Искусственные нейронные сети в кардиологии: анализ графических данных</article-title><trans-title-group xml:lang="en"><trans-title>Artificial neural networks in cardiology: analysis of graphic data</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2404-2873</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Онищенко</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Onishchenko</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>мл. науч. сотрудник, 650002, г. Кемерово, Сосновый бульвар, 6;</p><p>аспирант, лаборатория новых биоматериалов, 630090, г. Новосибирск, пр. Академика Лаврентьева, 6 </p><p> </p></bio><bio xml:lang="en"><p>6, Sosnovi Blv., Kemerovo, 650002;</p><p> 6, Akademika Lavrentieva Av., Novosibirsk, 630090</p></bio><email xlink:type="simple">onis.pavel@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клышников</surname><given-names>К. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Klyshnikov</surname><given-names>K. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>науч. сотрудник, лаборатория новых биоматериалов, ИВТ СО РАН, г. Новосибирск. ORCID0000-0003-3211-1250</p></bio><bio xml:lang="en"><p>6, Sosnovi Blv., Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7477-3979</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчаренко</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovcharenko</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. техн. наук, зав. лабораторией новых биоматериалов, </p><p> </p></bio><bio xml:lang="en"><p>6, Sosnovi Blv., Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ);&#13;
Институт вычислительных технологий Сибирского отделения Российской академии наук (ИВТ СО РАН)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases;&#13;
Science Institute of Computational Technologies of the Siberian Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>04</day><month>01</month><year>2022</year></pub-date><volume>20</volume><issue>4</issue><fpage>193</fpage><lpage>204</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Онищенко П.С., Клышников К.Ю., Овчаренко Е.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Онищенко П.С., Клышников К.Ю., Овчаренко Е.А.</copyright-holder><copyright-holder xml:lang="en">Onishchenko P.S., Klyshnikov K.Y., Ovcharenko E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/4596">https://bulletin.ssmu.ru/jour/article/view/4596</self-uri><abstract><p>Рассмотрены области применения сверточных нейронных сетей для обработки медицинских изображений в различных сферах кардиологии и кардиохирургии на примере публикаций с 2016 по 2019 г.</p><p>В данной работе использовались следующие базы научных статей: PubMed Central, ArXiv, ResearchGate. Приведенные работы структурировались по области интереса (сердце, аорта, сонные артерии).</p><p>Описан общий принцип работы рассматриваемой технологии, показаны результаты и рассмотрены основные области применения данной технологии в анализируемых работах. Для большинства приведенных исследований приведены объемы выборок, авторское видение развития сверточных нейронных сетей в медицине и перечислены некоторые ограничивающие факторы для их распространения.</p><p>Показаны возможные сферы применения сверточных нейронных сетей в области кардиологии и кардиохирургии. Не отрицая существующие проблемы, такой тип искусственных нейронных сетей в будущем может стать верным помощником для широкого спектра врачей и исследователей. </p></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To consider application of convolutional neural networks for processing medical images in various fields of cardiology and cardiac surgery using publications from 2016 to 2019 as an example.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. In the study, we used the following scientific databases: PubMed Central, ArXiv, ResearchGate. The cited publications were grouped by the area of interest (heart, aorta, carotid arteries).</p></sec><sec><title>Results</title><p>Results. The general principle of work of the technology under consideration was described, the results were shown, and the main areas of application of this technology in the studies under consideration were described. For most of the studies, sample sizes were given. The author’s view on the development of convolutional neural networks in medicine was presented and some limiting factors for their distribution were listed.</p></sec><sec><title>Conclusion</title><p>Conclusion. A brief overview shows possible areas of application of convolutional neural networks in the fields of cardiology and cardiac surgery. Without denying the existing problems, this type of artificial neural networks may help many doctors and researchers in the future. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>сверточные нейронные сети</kwd><kwd>CNN</kwd><kwd>FFR</kwd><kwd>кардиология</kwd><kwd>патология сердечно-сосудистой системы</kwd><kwd>стеноз</kwd><kwd>детекция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>convolutional neural network</kwd><kwd>CNN</kwd><kwd>FFR</kwd><kwd>cardiology</kwd><kwd>cardiovascular diseases</kwd><kwd>stenosis</kwd><kwd>detection</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при поддержке комплексной программы фундаментальных научных исследований СО РАН в рамках фундаментальной темы НИИ КПССЗ № 0419- 2021-001 «Разработка новых фармакологических подходов к экспериментальной терапии атеросклероза и комплексных цифровых решений на основе искусственного интеллекта для автоматизированной диагностики патологий системы кровообращения и определения риска летального исхода» при финансовой поддержке Министерства науки и высшего образования Российской Федерации в рамках национального проекта «Наука и университеты».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shen D., Wu G., Suk H.-I. Deep Learning in Medical Image Analysis. Annu. Rev. Biomed. Eng. 2017; 19: 221–248. DOI: 10.1146/annurev-bioeng-071516-044442.</mixed-citation><mixed-citation xml:lang="en">Shen D., Wu G., Suk H.-I. Deep Learning in Medical Image Analysis. Annu. Rev. Biomed. Eng. 2017; 19: 221–248. DOI: 10.1146/annurev-bioeng-071516-044442.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Smith B.J., Adhami R.R. Medical imaging. IEEE Potentials. 2000; 17 (5): 9–12. DOI: 10.1109/45.730965.</mixed-citation><mixed-citation xml:lang="en">Smith B.J., Adhami R.R. Medical imaging. IEEE Potentials. 2000; 17 (5): 9–12. DOI: 10.1109/45.730965.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bai W., Sinclair M., Tarroni G., Oktay O., Rajchl M., Vaillant G. et al. Automated cardiovascular magnetic resonance image analysis with fully convolutional networks 08 Information and Computing Sciences 0801 Artificial Intelligence and Image Processing. J Cardiovasc. Magn. Reson. 2018; 20 (1): 65. DOI: 10.1186/s12968-018-0471-x.</mixed-citation><mixed-citation xml:lang="en">Bai W., Sinclair M., Tarroni G., Oktay O., Rajchl M., Vaillant G. et al. Automated cardiovascular magnetic resonance image analysis with fully convolutional networks 08 Information and Computing Sciences 0801 Artificial Intelligence and Image Processing. J Cardiovasc. Magn. Reson. 2018; 20 (1): 65. DOI: 10.1186/s12968-018-0471-x.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Caterini A.L., Chang D.E. Recurrent neural networks. Springer Briefs Comput. Sci. 2018; 59–79.</mixed-citation><mixed-citation xml:lang="en">Caterini A.L., Chang D.E. Recurrent neural networks. Springer Briefs Comput. Sci. 2018; 59–79.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Nie D., Wang L., Gao Y., Sken D. Fully convolutional networks for multi-modality isointense infant brain image segmentation. Proc. – Int. Symp. Biomed. Imaging. 2016; 2016: 1342–1345. DOI: 10.1109/ISBI.2016.7493515.</mixed-citation><mixed-citation xml:lang="en">Nie D., Wang L., Gao Y., Sken D. Fully convolutional networks for multi-modality isointense infant brain image segmentation. Proc. – Int. Symp. Biomed. Imaging. 2016; 2016: 1342–1345. DOI: 10.1109/ISBI.2016.7493515.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Thaha M.M., Kumar K.P.M., Murugan B.S., Dhanasekeran S., Vijayakarthick P., Selvi A.S. Brain tumor segmentation using convolutional neural networks in MRI images. J. Med. Syst. 2019; 43 (9): 1240–1251. DOI: 10.1007/s10916-019-1416-0.</mixed-citation><mixed-citation xml:lang="en">Thaha M.M., Kumar K.P.M., Murugan B.S., Dhanasekeran S., Vijayakarthick P., Selvi A.S. Brain tumor segmentation using convolutional neural networks in MRI images. J. Med. Syst. 2019; 43 (9): 1240–1251. DOI: 10.1007/s10916-019-1416-0.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Suk H.I., Lee S.W., Shen D. Latent feature representation with stacked auto-encoder for AD/MCI diagnosis. Brain Struct. Funct. 2015; 220 (2): 841–859. DOI: 10.1007/s00429-013-0687-3.</mixed-citation><mixed-citation xml:lang="en">Suk H.I., Lee S.W., Shen D. Latent feature representation with stacked auto-encoder for AD/MCI diagnosis. Brain Struct. Funct. 2015; 220 (2): 841–859. DOI: 10.1007/s00429-013-0687-3.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Suk H.-I., Shen D. Deep learning in diagnosis of brain disorders. Recent. Prog. Brain Cogn. Eng. Springer. 2015; 203–213. DOI: 10.1007/978-94-017-7239-6_14.</mixed-citation><mixed-citation xml:lang="en">Suk H.-I., Shen D. Deep learning in diagnosis of brain disorders. Recent. Prog. Brain Cogn. Eng. Springer. 2015; 203–213. DOI: 10.1007/978-94-017-7239-6_14.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ronneberger O., Fischer P., Brox T. U-net: Convolutional networks for biomedical image segmentation. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics). 2015; 9351: 234–241.</mixed-citation><mixed-citation xml:lang="en">Ronneberger O., Fischer P., Brox T. U-net: Convolutional networks for biomedical image segmentation. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics). 2015; 9351: 234–241.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Milletari F., Navab N., Ahmadi S.A. V-Net: Fully convolutional neural networks for volumetric medical image seg mentation. Proc. – 2016 4th Int. Conf. 3D Vision, 3DV 2016. IEEE. 2016; 565–571.</mixed-citation><mixed-citation xml:lang="en">Milletari F., Navab N., Ahmadi S.A. V-Net: Fully convolutional neural networks for volumetric medical image seg mentation. Proc. – 2016 4th Int. Conf. 3D Vision, 3DV 2016. IEEE. 2016; 565–571.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Szegedy C., Toshev A., Erhan D. Deep Neural Networks for object detection. Adv. Neural Inf. Process. Syst. 2013; 2553– 2561.</mixed-citation><mixed-citation xml:lang="en">Szegedy C., Toshev A., Erhan D. Deep Neural Networks for object detection. Adv. Neural Inf. Process. Syst. 2013; 2553– 2561.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Taigman Y., Yang M., Ranzato M., Wolf L. DeepFace: Closing the gap to human-level performance in face verification. Proc. IEEE Comput. Soc. Conf. Comput. Vis. Pattern Recognit. 2018; 1701–1708. DOI: 10.1109/CVPR.2014.220.</mixed-citation><mixed-citation xml:lang="en">Taigman Y., Yang M., Ranzato M., Wolf L. DeepFace: Closing the gap to human-level performance in face verification. Proc. IEEE Comput. Soc. Conf. Comput. Vis. Pattern Recognit. 2018; 1701–1708. DOI: 10.1109/CVPR.2014.220.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Silver D., Huang A., Maddison C.J., Guez A., Sifre L., van den Driessche G. et al. Mastering the game of Go with deep neural networks and tree search. Nature. 2016; 529 (7587): 484–489. DOI: 10.1038/nature16961.</mixed-citation><mixed-citation xml:lang="en">Silver D., Huang A., Maddison C.J., Guez A., Sifre L., van den Driessche G. et al. Mastering the game of Go with deep neural networks and tree search. Nature. 2016; 529 (7587): 484–489. DOI: 10.1038/nature16961.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Razzak M.I., Naz S., Zaib A. Deep learning for medical image processing: Overview, challenges and the future. Lect. Notes Comput. Vis. Biomech. 2018; 26: 323–350.</mixed-citation><mixed-citation xml:lang="en">Razzak M.I., Naz S., Zaib A. Deep learning for medical image processing: Overview, challenges and the future. Lect. Notes Comput. Vis. Biomech. 2018; 26: 323–350.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Smistad E., Falch T.L., Bozorgi M., Elster A.C., Lindseth F. Medical image segmentation on GPUs - A comprehensive review. Med. Image Anal. 2015; 20 (1): 1–18. DOI: 10.1016/j.media.2014.10.012.</mixed-citation><mixed-citation xml:lang="en">Smistad E., Falch T.L., Bozorgi M., Elster A.C., Lindseth F. Medical image segmentation on GPUs - A comprehensive review. Med. Image Anal. 2015; 20 (1): 1–18. DOI: 10.1016/j.media.2014.10.012.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou T., Ruan S., Canu S. A review: Deep learning for medical image segmentation using multi-modality fusion. Array. 2019; 3–4: 100004. DOI: 10.1016/j.array.2019.100004.</mixed-citation><mixed-citation xml:lang="en">Zhou T., Ruan S., Canu S. A review: Deep learning for medical image segmentation using multi-modality fusion. Array. 2019; 3–4: 100004. DOI: 10.1016/j.array.2019.100004.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Russakovsky O., Deng J., Su H., Krause J., Satheesh S., Ma S., Huang Z., Karpathy A., Khosla A., Bernstein M., Berg A.C., Fei-Fei L. ImageNet large scale visual recognition challenge. Int. J. Comput. Vis. 2015; 115 (3): 211–252. DOI: 10.1007/s11263-015-0816-y.</mixed-citation><mixed-citation xml:lang="en">Russakovsky O., Deng J., Su H., Krause J., Satheesh S., Ma S., Huang Z., Karpathy A., Khosla A., Bernstein M., Berg A.C., Fei-Fei L. ImageNet large scale visual recognition challenge. Int. J. Comput. Vis. 2015; 115 (3): 211–252. DOI: 10.1007/s11263-015-0816-y.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Moeskops P., Wolterink J.M., van der Velden B.H., Gilhuijs K.G., Leiner T., Viergever M.A., Išgum I. Deep learning for multi-task medical image segmentation in multiple modalities. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics). 2016; 9901 LNCS: 478–486. DOI: 10.1007/978-3-319-46723-8_55.</mixed-citation><mixed-citation xml:lang="en">Moeskops P., Wolterink J.M., van der Velden B.H., Gilhuijs K.G., Leiner T., Viergever M.A., Išgum I. Deep learning for multi-task medical image segmentation in multiple modalities. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics). 2016; 9901 LNCS: 478–486. DOI: 10.1007/978-3-319-46723-8_55.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Baumgartner C.F., Koch L.M., Pollefeys M., Konukoglu E. An exploration of 2D and 3D deep learning techniques for cardiac MR image segmentation. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics.. 2018; 10663 LNCS: 111–119. DOI: 10.1007/978-3-319-75541-0_12.</mixed-citation><mixed-citation xml:lang="en">Baumgartner C.F., Koch L.M., Pollefeys M., Konukoglu E. An exploration of 2D and 3D deep learning techniques for cardiac MR image segmentation. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics.. 2018; 10663 LNCS: 111–119. DOI: 10.1007/978-3-319-75541-0_12.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pesapane F., Codari M., Sardanelli F. Artificial intelligence in medical imaging: threat or opportunity? Radiologists again at the forefront of innovation in medicine. Eur. Radiol. Exp. 2018; 2 (1): 35. DOI: 10.1186/s41747-018-0061-6.</mixed-citation><mixed-citation xml:lang="en">Pesapane F., Codari M., Sardanelli F. Artificial intelligence in medical imaging: threat or opportunity? Radiologists again at the forefront of innovation in medicine. Eur. Radiol. Exp. 2018; 2 (1): 35. DOI: 10.1186/s41747-018-0061-6.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Брюхомицкий Ю.А. Нейросетевые модели для систем информационной безопасности. Таганрог: ТРТУ, 2005: 160. 22. Kim M., Yun J., Cho Y., Shin K., Jang R., Bae H., Kim N. Deep learning in medical imaging. Neurospine. 2019; 16 (4): 657–668. DOI: 10.14245/ns.1938396.198.</mixed-citation><mixed-citation xml:lang="en">Брюхомицкий Ю.А. Нейросетевые модели для систем информационной безопасности. Таганрог: ТРТУ, 2005: 160. 22. Kim M., Yun J., Cho Y., Shin K., Jang R., Bae H., Kim N. Deep learning in medical imaging. Neurospine. 2019; 16 (4): 657–668. DOI: 10.14245/ns.1938396.198.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Krittanawong C., Tunhasiriwet A., Zhang H.J., Wang Z., Aydar M., Kitai T. Deep learning with unsupervised feature in echocardiographic imaging. J. Am. Coll. Cardiol. 2017; 69 (16): 2100–2101. DOI: 10.1016/j.jacc.2016.12.047.</mixed-citation><mixed-citation xml:lang="en">Krittanawong C., Tunhasiriwet A., Zhang H.J., Wang Z., Aydar M., Kitai T. Deep learning with unsupervised feature in echocardiographic imaging. J. Am. Coll. Cardiol. 2017; 69 (16): 2100–2101. DOI: 10.1016/j.jacc.2016.12.047.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao Y., Xia X., Togneri R. Applications of deep learning to audio generation. IEEE Circuits Syst. Mag. 2019; 19 (4): 19–38. DOI: 10.1109/MCAS.2019.2945210.</mixed-citation><mixed-citation xml:lang="en">Zhao Y., Xia X., Togneri R. Applications of deep learning to audio generation. IEEE Circuits Syst. Mag. 2019; 19 (4): 19–38. DOI: 10.1109/MCAS.2019.2945210.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">LeCun Y., Bengio Y., Hinton G. Deep learning. Nature. 2015; 521 (7553): 436–444. DOI: 10.1038/nature14539.</mixed-citation><mixed-citation xml:lang="en">LeCun Y., Bengio Y., Hinton G. Deep learning. Nature. 2015; 521 (7553): 436–444. DOI: 10.1038/nature14539.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta A., Ayhan M.S., Maida A.S. Natural image bases to represent neuroimaging data. 30th Int. Conf. Mach. Learn. ICML 2013. 2013; 2024–2031.</mixed-citation><mixed-citation xml:lang="en">Gupta A., Ayhan M.S., Maida A.S. Natural image bases to represent neuroimaging data. 30th Int. Conf. Mach. Learn. ICML 2013. 2013; 2024–2031.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Brosch T., Tam R. Initiative for the Alzheimers Disease Neuroimaging. Manifold Learn brain MRIs by Deep Learning Med. Image Comput. Assist. Interv. 2013; 16 (2): 633–640. DOI: 10.1007/978-3-642-40763-5_78.</mixed-citation><mixed-citation xml:lang="en">Brosch T., Tam R. Initiative for the Alzheimers Disease Neuroimaging. Manifold Learn brain MRIs by Deep Learning Med. Image Comput. Assist. Interv. 2013; 16 (2): 633–640. DOI: 10.1007/978-3-642-40763-5_78.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Yu L., Guo Y., Wang Y., Yu J., Chen P. Segmentation of fetal left ventricle in echocardiographic sequences based on dynamic convolutional neural networks. IEEE Trans. Biomed. Eng. 2017; 64 (8): 1886–1895. DOI: 10.1109/TBME.2016.2628401.</mixed-citation><mixed-citation xml:lang="en">Yu L., Guo Y., Wang Y., Yu J., Chen P. Segmentation of fetal left ventricle in echocardiographic sequences based on dynamic convolutional neural networks. IEEE Trans. Biomed. Eng. 2017; 64 (8): 1886–1895. DOI: 10.1109/TBME.2016.2628401.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Xue W., Brahm G., Pandey S., Leung S., Li S. Full left ventricle quantification via deep multitask relationships learning. Med. Image Anal. 2018; 43: 54–65. DOI: 10.1016/j.media.2017.09.005.</mixed-citation><mixed-citation xml:lang="en">Xue W., Brahm G., Pandey S., Leung S., Li S. Full left ventricle quantification via deep multitask relationships learning. Med. Image Anal. 2018; 43: 54–65. DOI: 10.1016/j.media.2017.09.005.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Xue W., Lum A., Mercado A., Landis M., Warrington J., Li S. Full quantification of left ventricle via deep multitask learning network respecting intra- and inter-task relatedness. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics). 2017; 10435 LNCS: 276–284. DOI: 10.1007/978-3-319-66179-7_32.</mixed-citation><mixed-citation xml:lang="en">Xue W., Lum A., Mercado A., Landis M., Warrington J., Li S. Full quantification of left ventricle via deep multitask learning network respecting intra- and inter-task relatedness. Lect. Notes Comput. Sci. (including Subser. Lect. Notes Artif. Intell. Lect. Notes Bioinformatics). 2017; 10435 LNCS: 276–284. DOI: 10.1007/978-3-319-66179-7_32.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Dormer J.D., Fei B., Halicek M., Ma L., Reilly C.M., Schreibmann E. Heart chamber segmentation from CT using convolutional neural networks. Med. Imaging 2018 Biomed. Appl. Mol. Struct. Funct. Imaging, vol. 10578. International Society for Optics and Photonics. 2018; 100. DOI: 10.1117/12.2293554.</mixed-citation><mixed-citation xml:lang="en">Dormer J.D., Fei B., Halicek M., Ma L., Reilly C.M., Schreibmann E. Heart chamber segmentation from CT using convolutional neural networks. Med. Imaging 2018 Biomed. Appl. Mol. Struct. Funct. Imaging, vol. 10578. International Society for Optics and Photonics. 2018; 100. DOI: 10.1117/12.2293554.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Tan L.K., McLaughlin R.A., Lim E., Abdul Aziz Y.F., Liew Y.M. Fully automated segmentation of the left ventricle in cine cardiac MRI using neural network regression. J. Magn. Reson. Imaging. 2018; 48 (1): 140–152. DOI: 10.1002/jmri.25932.</mixed-citation><mixed-citation xml:lang="en">Tan L.K., McLaughlin R.A., Lim E., Abdul Aziz Y.F., Liew Y.M. Fully automated segmentation of the left ventricle in cine cardiac MRI using neural network regression. J. Magn. Reson. Imaging. 2018; 48 (1): 140–152. DOI: 10.1002/jmri.25932.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D., Zhang R., Zhu J., Teng Z., Huang Y., Spiga F., Du M.H.-F., Gillard J.H., Lu Q., Liò P. Neural network fusion: a novel CT-MR aortic aneurysm image segmentation method. Med. Imaging 2018 Image Process. 2018; 10574: 75. DOI: 10.1117/12.2293371.</mixed-citation><mixed-citation xml:lang="en">Wang D., Zhang R., Zhu J., Teng Z., Huang Y., Spiga F., Du M.H.-F., Gillard J.H., Lu Q., Liò P. Neural network fusion: a novel CT-MR aortic aneurysm image segmentation method. Med. Imaging 2018 Image Process. 2018; 10574: 75. DOI: 10.1117/12.2293371.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Graffy P.M., Liu J., Pickhardt P.J., Burns J.E., Yao J., Summers R.M. Deep learning-based muscle segmentation and quantifcation at abdominal CT: Application to a longitudinal adult screening cohort for sarcopenia assessment. Br. J. Radiol. 2019; 92 (1100): 2921–2928. DOI: 10.1259/bjr.20190327.</mixed-citation><mixed-citation xml:lang="en">Graffy P.M., Liu J., Pickhardt P.J., Burns J.E., Yao J., Summers R.M. Deep learning-based muscle segmentation and quantifcation at abdominal CT: Application to a longitudinal adult screening cohort for sarcopenia assessment. Br. J. Radiol. 2019; 92 (1100): 2921–2928. DOI: 10.1259/bjr.20190327.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">He K., Gkioxari G., Dollár P., Girshick R. Mask r-cnn. Proc. IEEE. Int. Conf. Comput. Vis. 2017; 2961–2969. DOI: 10.1109/ICCV.2017.322.</mixed-citation><mixed-citation xml:lang="en">He K., Gkioxari G., Dollár P., Girshick R. Mask r-cnn. Proc. IEEE. Int. Conf. Comput. Vis. 2017; 2961–2969. DOI: 10.1109/ICCV.2017.322.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pickhardt P.J. Imaging and screening for colorectal cancer with CT colonography. Radiol. Clin. North Am. 2017; 55 (6): 1183–1196. DOI: 10.1016/j.rcl.2017.06.009.</mixed-citation><mixed-citation xml:lang="en">Pickhardt P.J. Imaging and screening for colorectal cancer with CT colonography. Radiol. Clin. North Am. 2017; 55 (6): 1183–1196. DOI: 10.1016/j.rcl.2017.06.009.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Neves P.O., Andrade J., Monção H. Escore de cálcio coronariano: Estado atual. Radiol Bras. 2017; 50 (3): 182–189. DOI: 10.1590/0100-3984.2015.0235.</mixed-citation><mixed-citation xml:lang="en">Neves P.O., Andrade J., Monção H. Escore de cálcio coronariano: Estado atual. Radiol Bras. 2017; 50 (3): 182–189. DOI: 10.1590/0100-3984.2015.0235.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Segal B.L. The pathology of coronary heart disease. Can. Med. Assoc. J. 1962; 87 (26): 1387–1390.</mixed-citation><mixed-citation xml:lang="en">Segal B.L. The pathology of coronary heart disease. Can. Med. Assoc. J. 1962; 87 (26): 1387–1390.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Wal A.C. Coronary artery pathology. Heart. 2007; 93 (11): 1484–1489. DOI: 10.1136/hrt.2004.038364.</mixed-citation><mixed-citation xml:lang="en">Van der Wal A.C. Coronary artery pathology. Heart. 2007; 93 (11): 1484–1489. DOI: 10.1136/hrt.2004.038364.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Nasr-Esfahani E., Samavi S., Karimi N., Soroushmehr S.R., Ward K., Jafari M.H., Felfeliyan B., Nallamothu B., Najarian K. Vessel extraction in X-ray angiograms using deep learning. Proc. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2016; 2016: 643–646. DOI: 10.1109/EMBC.2016.7590784.</mixed-citation><mixed-citation xml:lang="en">Nasr-Esfahani E., Samavi S., Karimi N., Soroushmehr S.R., Ward K., Jafari M.H., Felfeliyan B., Nallamothu B., Najarian K. Vessel extraction in X-ray angiograms using deep learning. Proc. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2016; 2016: 643–646. DOI: 10.1109/EMBC.2016.7590784.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Wolterink J.M., Hamersvelt R.W., Viergever M.A., Leiner T., Išgum I. Coronary artery centerline extraction in cardiac CT angiography using a CNN-based orientation classifier. Med. Image Anal. 2019; 51: 46–60. DOI: 10.1016/j.media.2018.10.005.</mixed-citation><mixed-citation xml:lang="en">Wolterink J.M., Hamersvelt R.W., Viergever M.A., Leiner T., Išgum I. Coronary artery centerline extraction in cardiac CT angiography using a CNN-based orientation classifier. Med. Image Anal. 2019; 51: 46–60. DOI: 10.1016/j.media.2018.10.005.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Yong Y.L., Tan L.K., McLaughlin R.A., Chee K.H., Liew Y.M. Linear-regression convolutional neural network for fully automated coronary lumen segmentation in intravascular optical coherence tomography. J. Biomed. Opt. 2017; 22 (12): 1–9. DOI: 10.1117/1.jbo.22.12.126005.</mixed-citation><mixed-citation xml:lang="en">Yong Y.L., Tan L.K., McLaughlin R.A., Chee K.H., Liew Y.M. Linear-regression convolutional neural network for fully automated coronary lumen segmentation in intravascular optical coherence tomography. J. Biomed. Opt. 2017; 22 (12): 1–9. DOI: 10.1117/1.jbo.22.12.126005.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Dice L.R. Measures of the amount of ecologic association between species. Ecology. 1945; 26 (3): 297–302. DOI: 10.2307/1932409.</mixed-citation><mixed-citation xml:lang="en">Dice L.R. Measures of the amount of ecologic association between species. Ecology. 1945; 26 (3): 297–302. DOI: 10.2307/1932409.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Zou K.H., Warfield S.K., Bharatha A., Tempany C.M.C., Kaus M.R., Haker S.J., Wells W.M., Jolesz F.A., Kikinis R. Statistical validation of image segmentation quality based on a spatial overlap index. Acad. Radiol. 2004; 11 (2): 178–189. DOI: 10.1016/S1076-6332(03)00671-8.</mixed-citation><mixed-citation xml:lang="en">Zou K.H., Warfield S.K., Bharatha A., Tempany C.M.C., Kaus M.R., Haker S.J., Wells W.M., Jolesz F.A., Kikinis R. Statistical validation of image segmentation quality based on a spatial overlap index. Acad. Radiol. 2004; 11 (2): 178–189. DOI: 10.1016/S1076-6332(03)00671-8.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Pijls N.H., De Bruyne B., Peels K., van der Voort P.H., Bonnier H.J.R.M., Bartunek J., Koolen J.J. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N. Engl. J. Med. 1996; 334 (26): 1703–1708. DOI: 10.1056/NEJM199606273342604.</mixed-citation><mixed-citation xml:lang="en">Pijls N.H., De Bruyne B., Peels K., van der Voort P.H., Bonnier H.J.R.M., Bartunek J., Koolen J.J. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N. Engl. J. Med. 1996; 334 (26): 1703–1708. DOI: 10.1056/NEJM199606273342604.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Stegehuis V.E., Wijntjens G.W., Piek J.J., van de Hoef T.P. Fractional flow reserve or coronary flow reserve for the assessment of myocardial perfusion: Implications of FFR as an imperfect reference standard for myocardial ischemia. Curr. Cardiol. Rep. 2018; 20 (9): 77. DOI: 10.1007/s11886-018-1017-4.</mixed-citation><mixed-citation xml:lang="en">Stegehuis V.E., Wijntjens G.W., Piek J.J., van de Hoef T.P. Fractional flow reserve or coronary flow reserve for the assessment of myocardial perfusion: Implications of FFR as an imperfect reference standard for myocardial ischemia. Curr. Cardiol. Rep. 2018; 20 (9): 77. DOI: 10.1007/s11886-018-1017-4.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Zreik M., Lessmann N., van Hamersvel R.W., Wolterink J.M., Voskuil M., Viergever M. A., Leinerb T., Išgum I. Deep learning analysis of the myocardium in coronary CT angiography for identification of patients with functionally significant coronary artery stenosis. Med. Image Anal. 2018; 44: 72–85. DOI: 10.1016/j.media.2017.11.008.</mixed-citation><mixed-citation xml:lang="en">Zreik M., Lessmann N., van Hamersvel R.W., Wolterink J.M., Voskuil M., Viergever M. A., Leinerb T., Išgum I. Deep learning analysis of the myocardium in coronary CT angiography for identification of patients with functionally significant coronary artery stenosis. Med. Image Anal. 2018; 44: 72–85. DOI: 10.1016/j.media.2017.11.008.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Van Hamersvelt R.W., Zreik M., Voskuil M., Viergever M.A., Išgum I., Leiner T. Deep learning analysis of left ventricular myocardium in CT angiographic intermediate-degree coronary stenosis improves the diagnostic accuracy for identification of functionally significant stenosis. Eur. Radiol. 2019; 29 (5): 2350–2359. DOI: 10.1007/s00330-018-5822-3.</mixed-citation><mixed-citation xml:lang="en">Van Hamersvelt R.W., Zreik M., Voskuil M., Viergever M.A., Išgum I., Leiner T. Deep learning analysis of left ventricular myocardium in CT angiographic intermediate-degree coronary stenosis improves the diagnostic accuracy for identification of functionally significant stenosis. Eur. Radiol. 2019; 29 (5): 2350–2359. DOI: 10.1007/s00330-018-5822-3.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Itu L., Rapaka S., Passerini T., Georgescu B., Schwemmer C., Schoebinger M., Flohr T., Sharma P., Comaniciu D. A machine-learning approach for computation of fractional flow reserve from coronary computed tomography. J. Appl. Physiol. 2016; 121 (1): 42–52. DOI: 10.1152/japplphysiol.00752.2015.</mixed-citation><mixed-citation xml:lang="en">Itu L., Rapaka S., Passerini T., Georgescu B., Schwemmer C., Schoebinger M., Flohr T., Sharma P., Comaniciu D. A machine-learning approach for computation of fractional flow reserve from coronary computed tomography. J. Appl. Physiol. 2016; 121 (1): 42–52. DOI: 10.1152/japplphysiol.00752.2015.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Wang L., Xie X.L., Bian G.B., Hou Z.G., Cheng X.R., Prasong P. Guide-wire detection using region proposal network for X-ray image-guided navigation. Proc. Int. Jt. Conf. Neural Networks. 2017; 2017: 3169–3175. DOI: 10.1109/IJCNN.2017.7966251.</mixed-citation><mixed-citation xml:lang="en">Wang L., Xie X.L., Bian G.B., Hou Z.G., Cheng X.R., Prasong P. Guide-wire detection using region proposal network for X-ray image-guided navigation. Proc. Int. Jt. Conf. Neural Networks. 2017; 2017: 3169–3175. DOI: 10.1109/IJCNN.2017.7966251.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Yang H., Shan C., Kolen A.F., de With P.H.N. Catheter localization in 3D ultrasound using voxel-of-interest-based ConvNets for cardiac intervention. Int. J. Comput. Assist. Radiol. Surg. 2019; 14 (6): 1069–1077. DOI: 10.1007/s11548-019-01960-y.</mixed-citation><mixed-citation xml:lang="en">Yang H., Shan C., Kolen A.F., de With P.H.N. Catheter localization in 3D ultrasound using voxel-of-interest-based ConvNets for cardiac intervention. Int. J. Comput. Assist. Radiol. Surg. 2019; 14 (6): 1069–1077. DOI: 10.1007/s11548-019-01960-y.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Lee H., Mansouri M., Tajmir S., Lev M.H., Do S. A deep-learning system for fully-automated peripherally inserted central catheter (PICC) tip detection. J. Digit. Imaging. 2018; 31 (4): 393–402. DOI: 10.1007/s10278-017-0025-z.</mixed-citation><mixed-citation xml:lang="en">Lee H., Mansouri M., Tajmir S., Lev M.H., Do S. A deep-learning system for fully-automated peripherally inserted central catheter (PICC) tip detection. J. Digit. Imaging. 2018; 31 (4): 393–402. DOI: 10.1007/s10278-017-0025-z.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Shelhamer E., Long J., Darrell T. Fully сonvolutional networks for semantic segmentation. IEEE Trans. Pattern Anal. Mach. Intell. 2017; 39 (4): 640–651. DOI: 10.1109/TPAMI.2016.2572683.</mixed-citation><mixed-citation xml:lang="en">Shelhamer E., Long J., Darrell T. Fully сonvolutional networks for semantic segmentation. IEEE Trans. Pattern Anal. Mach. Intell. 2017; 39 (4): 640–651. DOI: 10.1109/TPAMI.2016.2572683.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
