ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2012-2-133-138ssmu-464Research ArticleОТ НАУКИ К ПРАКТИКЕFROM SCIENCE TO PRACTICEПути оптимизации медикаментозного лечения больных с доброкачественной гиперплазией предстательной железы I—II стадииResults of application of a combination of Doksazozina and Indigala in therapy of men with prostate adenoma I—II stagesПавловВ. Н.PavlovV. N.alberturo@mail.ruКазихинуровА. А.KazikhinurovА. А.alberturo@mail.ruИзмайловА. А.IzmaylovA. A.alberturo@mail.ruБояркоА. В.BoyarkoA. V.alberturo@mail.ruПапоянА. О.PapoyanA. O.alberturo@mail.ruАбдрахимовР. В.AbdrakhimovR. V.alberturo@mail.ruБашкирский государственный медицинский университет, г. УфаRussian Federation201228042012112133138Copyright © Павлов В.Н., Казихинуров А.А., Измайлов А.А., Боярко А.В., Папоян А.О., Абдрахимов Р.В., 20122012Павлов В.Н., Казихинуров А.А., Измайлов А.А., Боярко А.В., Папоян А.О., Абдрахимов Р.В.Pavlov V.N., Kazikhinurov А.А., Izmaylov A.A., Boyarko A.V., Papoyan A.O., Abdrakhimov R.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/464

В работе предложен способ консервативной терапии мужчин с доброкачественной гиперплазией предстательной железы (ДГПЖ) I—II стадии с использованием комбинации доксазозина и индигала, отличающегося антиоксидантными, антипролиферативными и противовоспалительными свойствами, что позволило улучшить уродинамические показатели и замедлить прогрессирование ДГПЖ, сведя к минимуму нежелательные эффекты лечения.

In work the way of conservative therapy of men with prostate adenoma I—II of a stage with use of a combination of Doksazozina and Indigala different antioxidantiv, antiproliferative and anti-inflammatory properties that has allowed to improve urodynamic indicators is offered and to slow down progressing prostate adenoma, having reduced to a minimum undesirable effects of treatment.

индол-3-карбинолэпигаллокатехин-3-галлатдоброкачественная гиперплазия предстательной железынижние мочевыводящие путиan indole-3-karbinolepigallokatehin-3-gallatprostate adenomabottom urowaysReferencesAhmad N., Feyes D.K., Nieminen A.L., Agarwal R., Mukh-tar. Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carci-noma cells // J. Natl. Cancer Inst. 1997. № 89. Р. 1881—1886.Ahmad N., Feyes D.K., Nieminen A.L., Agarwal R., Mukh-tar. Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carci-noma cells // J. Natl. Cancer Inst. 1997. № 89. Р. 1881—1886.Bradlow H.L., Sepkovic D.W., Telang N.T., Osborne M.P. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent // Ann. NY Acad. Sci. 1999. № 889. Р. 204—213.Bradlow H.L., Sepkovic D.W., Telang N.T., Osborne M.P. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent // Ann. NY Acad. Sci. 1999. № 889. Р. 204—213.Chinni S.R., Li Y., Upadhyay S. et al. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells // Oncogene. 2001. № 20. Р. 2927—2936.Chinni S.R., Li Y., Upadhyay S. et al. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells // Oncogene. 2001. № 20. Р. 2927—2936.Chinni S.R., Sarkar F.H. Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells // Clin. Cancer Res. 2002. № 8. Р. 1228—123.Chinni S.R., Sarkar F.H. Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells // Clin. Cancer Res. 2002. № 8. Р. 1228—123.Fujimoto N, Sueoka N, Sueoka E, et al. Lung cancer preven-tion with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1 // Int. J. Oncol. 2002. № 20. Р. 1233—1239.Fujimoto N, Sueoka N, Sueoka E, et al. Lung cancer preven-tion with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1 // Int. J. Oncol. 2002. № 20. Р. 1233—1239.Gupta S., Hussain T., Mukhtar H. Molecular pathway forGupta S., Hussain T., Mukhtar H. Molecular pathway for(-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells // Arch. Bio-chem. Biophys. 2003. № 410 (1). Р. 177—185.(-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells // Arch. Bio-chem. Biophys. 2003. № 410 (1). Р. 177—185.Jin L., Qi M., Chen D.Z. et al. Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice // Cancer Res. 1999. № 59. Р. 3991—3997.Jin L., Qi M., Chen D.Z. et al. Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice // Cancer Res. 1999. № 59. Р. 3991—3997.Jung Y.D., Kim M.S., Shin B.A. et al. EGCG, a major com-ponent of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells // Br. J. Cancer. 2001. № 84. Р. 844—850.Jung Y.D., Kim M.S., Shin B.A. et al. EGCG, a major com-ponent of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells // Br. J. Cancer. 2001. № 84. Р. 844—850.Kondo T., Ohta T., Igura K. et al. Tea catechins inhibit angiogenesis in vitro, measured by human endothelial cell growth, migration and tube formation, through inhibition of VEGF receptor binding, 2002, 180(2), Р. 139—144.Kondo T., Ohta T., Igura K. et al. Tea catechins inhibit angiogenesis in vitro, measured by human endothelial cell growth, migration and tube formation, through inhibition of VEGF receptor binding, 2002, 180(2), Р. 139—144.Kundu J.K., Na H.K., Chun K.S. et al. Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells // J. Nutr. 2003. 133 (11 Supl. 1) Р. 3805S—3810.Kundu J.K., Na H.K., Chun K.S. et al. Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells // J. Nutr. 2003. 133 (11 Supl. 1) Р. 3805S—3810.Lamy S., Gingras D., Beliveau R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation // Cancer Res. 2002. № 62. Р. 381—385.Lamy S., Gingras D., Beliveau R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation // Cancer Res. 2002. № 62. Р. 381—385.Le H.T., Schaldach C.M., Bjeldanes L.F. Plant-derived 3,3’-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells // J. Biol. Chem. 2003. 278. Р. 21136—21145.Le H.T., Schaldach C.M., Bjeldanes L.F. Plant-derived 3,3’-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells // J. Biol. Chem. 2003. 278. Р. 21136—21145.Li Y., Li X., Sarkar F.H. Gene expression profiles of I3C- and DIM-treated PC3 human cancer cell line, PC3, by 3,3’-diindolylmethane through the mitochondrial pathway // Br. J. Cancer. 2004. № 91. Р. 1358—1363.Li Y., Li X., Sarkar F.H. Gene expression profiles of I3C- and DIM-treated PC3 human cancer cell line, PC3, by 3,3’-diindolylmethane through the mitochondrial pathway // Br. J. Cancer. 2004. № 91. Р. 1358—1363.Masuda M., Suzuki M., Lim J.T.E., Weinstein I.B. Epigallo-catechin-3-gallate Inhibits Activation of HER-2/neu and Downstream Signaling Pathways in Human Head and Neck and Breast Carcinoma Cells // Clin. Cancer Res. 2003. № 9. Р. 3486—3491.Masuda M., Suzuki M., Lim J.T.E., Weinstein I.B. Epigallo-catechin-3-gallate Inhibits Activation of HER-2/neu and Downstream Signaling Pathways in Human Head and Neck and Breast Carcinoma Cells // Clin. Cancer Res. 2003. № 9. Р. 3486—3491.Sah J.F., Balasubramanian S., Eckert R.L., Rorke E.A. Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor Receptor Signaling Pathway // J. Biol. Chem. 2004. № 279. Р. 12755—12762.Sah J.F., Balasubramanian S., Eckert R.L., Rorke E.A. Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor Receptor Signaling Pathway // J. Biol. Chem. 2004. № 279. Р. 12755—12762.Sartippour M.R., Shao Z.M., Heber D. et al. Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells // J. Nutr. 2002. № 132. Р. 2307—2311.Sartippour M.R., Shao Z.M., Heber D. et al. Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells // J. Nutr. 2002. № 132. Р. 2307—2311.Zhang J., Hsu B.A.J., Kinseth B.A.M. et al. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells // Cancer. 2003. № 98. Р. 2511—2520.Zhang J., Hsu B.A.J., Kinseth B.A.M. et al. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells // Cancer. 2003. № 98. Р. 2511—2520.Riby J.E., Firestone G.L., Bjeldanes L.F. 3,3’-diindolylme-thane reduces levels of HIF-1alpha and HIF-1 activity in hy-poxic cultured human cancer cells // Biochem. Pharmacol. 2008. № 75 (9). Р. 1858—1867.Riby J.E., Firestone G.L., Bjeldanes L.F. 3,3’-diindolylme-thane reduces levels of HIF-1alpha and HIF-1 activity in hy-poxic cultured human cancer cells // Biochem. Pharmacol. 2008. № 75 (9). Р. 1858—1867.

The authors declare that there are no conflicts of interest present.