ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2022-3-198-204ssmu-4921Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРоль катепсина S в патофизиологии бронхиальной астмыThe role of cathepsin S in the pathophysiology of bronchial asthmahttps://orcid.org/0000-0001-6896-877XКрапошинаА. Ю.KraposhinaA. Yu.

Собко Елена Альбертовна – доктор медицинских наук, профессор, профессор кафедры госпитальной терапии и иммунологии с курсом ПО, КрасГМУ им. профессора В.Ф. Войно-Ясенецкого; зав. отделением аллергологии, Краевая клиническая больница.

660022, Красноярск, ул. Партизана Железняка, 1; 660022, Красноярск, ул. Партизана Железняка, 3а

1, Partizana Zeleznyaka Str., Krasnoyarsk, 660022; 3а, Partizana Zeleznyaka Str., Krasnoyarsk, 660022

angelina-maria@inbox.ruhttps://orcid.org/0000-0002-9377-5213СобкоЕ. А.SobkoE. А.

Демко Ирина Владимировна – доктор медицинских наук, профессор, заведующий кафедрой госпитальной терапии и иммунологии с курсом ПО, КрасГМУ им. профессора В.Ф. Войно-Ясенецкого; зав. легочно-аллергологическим центром, Краевая клиническая больница.

660022, Красноярск, ул. Партизана Железняка, 1; 660022, Красноярск, ул. Партизана Железняка, 3а

1, Partizana Zeleznyaka Str., Krasnoyarsk, 660022; 3а, Partizana Zeleznyaka Str., Krasnoyarsk, 660022

sobko29@mail.ruhttps://orcid.org/0000-0001-8982-5292ДемкоИ. В.DemkoI. V.

Демко Ирина Владимировна – доктор медицинских наук, профессор, заведующий кафедрой госпитальной терапии и иммунологии с курсом ПО, КрасГМУ им. профессора В.Ф. Войно-Ясенецкого; зав. легочно-аллергологическим центром, Краевая клиническая больница.

660022, Красноярск, ул. Партизана Железняка, 1; 660022, Красноярск, ул. Партизана Железняка, 3а

1, Partizana Zeleznyaka Str., Krasnoyarsk, 660022; 3а, Partizana Zeleznyaka Str., Krasnoyarsk, 660022

demko64@mail.ruhttps://orcid.org/0000-0001-7999-4113КазмерчукО. В.KazmerchukO. V.

Казмерчук Ольга Витальевна – ординатор, кафедра госпитальной терапии и иммунологии с курсом ПО, КрасГМУ им. профессора В.Ф. Войно-Ясенецкого.

660022, Красноярск, ул. Партизана Железняка, 1

1, Partizana Zeleznyaka Str., Krasnoyarsk, 660022

olguna24@mail.ruhttps://orcid.org/0000-0002-6649-8900КацерА. Б.KacerA. B.

Кацер Анна Борисовна – ординатор, кафедра госпитальной терапии и иммунологии с курсом ПО, КрасГМУ им. профессора В.Ф. Войно-Ясенецкого.

660022, Красноярск, ул. Партизана Железняка, 1

1, Partizana Zeleznyaka Str., Krasnoyarsk, 660022

lesmotsfors@mail.ruhttps://orcid.org/0000-0002-9937-1025АбрамовЮ. И.AbramovYu. I.

Абрамов Юрий Игоревич – ординатор, кафедра поликлинической терапии и семейной медицины с курсом ПО, КрасГМУ им. профессора В.Ф. Войно-Ясенецкого.

660022, Красноярск, ул. Партизана Железняка, 1

1, Partizana Zeleznyaka Str., Krasnoyarsk, 660022

yuriyab1997@gmail.comКрасноярский государственный медицинский университет (КрасГМУ) им. профессора В.Ф. Войно-Ясенецкого; Краевая клиническая больницаРоссияV.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical HospitalRussian FederationКрасноярский государственный медицинский университет (КрасГМУ) им. профессора В.Ф. Войно-ЯсенецкогоРоссияV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation202215102022213198204Copyright © Крапошина А.Ю., Собко Е.А., Демко И.В., Казмерчук О.В., Кацер А.Б., Абрамов Ю.И., 20222022Крапошина А.Ю., Собко Е.А., Демко И.В., Казмерчук О.В., Кацер А.Б., Абрамов Ю.И.Kraposhina A.Y., Sobko E.А., Demko I.V., Kazmerchuk O.V., Kacer A.B., Abramov Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/4921

До настоящего времени сохраняет свою актуальность изучение роли ферментов – протеаз в патогенезе различных заболеваний. Многообразие функций катепсинов обусловлено особенностями их локализации, экспрессии и регуляции, благодаря чему они принимают участие в развитии многих патологических процессов. Дисрегуляция активности протеаз, их ингибиторов и субстратов может привести к развитию полиорганных заболеваний.

В обзорной статье представлены данные о характеристике всего семейства катепсинов и катепсина S в частности; описаны его патофизиологические роли при формировании бронхолегочных патологий, а также при бронхиальной астме; освещены внутрии внеклеточные механизмы реализации. Авторы считают, именно этот фермент может стать мишенью для таргетной терапии астмы с целью предотвращения ремоделирования бронхиальной стенки на самых ранних этапах заболевания. Поиск литературы осуществлялся в поисковых системах Medline, еLibrary, Scopus, The Cochrane Library, РИНЦ.

To date, the study of the role of proteases in the pathogenesis of various diseases remains relevant. The variety of cathepsin functions is associated with the peculiarities of their localization, expression, and regulation, due to which cathepsins are involved in development of many pathologies. Dysregulation of proteases, their inhibitors, and substrates can lead to the development of multiple organ dysfunction.

The review presents data on the characteristics of the entire family of cathepsins and cathepsin S, in particular. The pathophysiological role of cathepsin S in the formation of bronchopulmonary pathologies, as well as in bronchial asthma is described, and intraand extracellular implementation mechanisms are considered. The authors believe it is this enzyme that could be targeted in targeted asthma therapy to prevent airway wall remodeling at the earliest stages of the disease. The literature search was carried out in the search engines Medline, eLibrary, Scopus, the Cochrane Library, and RSCI.

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The authors declare that there are no conflicts of interest present.