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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2012-3-120-131</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-505</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОТ НАУКИ К ПРАКТИКЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FROM SCIENCE TO PRACTICE</subject></subj-group></article-categories><title-group><article-title>Использование 199Tl-хлорида и 99mTc-МИБИ для индикации и дифференциальной диагностики опухолевых и воспалительных процессов опорно-двигательного аппарата</article-title><trans-title-group xml:lang="en"><trans-title>Using of 199Tl-сhloride and 99mTc-MIBI in indications and differential diagnostics inflammatory and neoplastic processes of musculoskeletal system</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куражов</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kourazhov</surname><given-names>A. P.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Завадовская</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Zavadovskaya</surname><given-names>V. D.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Килина</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kilina</surname><given-names>O. Yu.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зоркальцев</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zorkaltsev</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чойнзонов</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Choinzonov</surname><given-names>Ye. L.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernov</surname><given-names>V. I.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слонимская</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Slonimskaya</surname><given-names>Ye. M.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богоутдинова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogoutdinova</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анисеня</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Anisenya</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тицкая</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Titskaya</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зельчан</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zelchan</surname><given-names>R. V.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролова</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolova</surname><given-names>I. G.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сапунова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sapunova</surname><given-names>L. S.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Удодов</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Udodov</surname><given-names>V. D.</given-names></name></name-alternatives><email xlink:type="simple">Kurazhovap@mail.RU</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Сибирский государственный медицинский университет, г. Томск</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>НИИ онкологии СО РАМН, г. Томск</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2012</year></pub-date><volume>11</volume><issue>3</issue><fpage>120</fpage><lpage>131</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Куражов А.П., Завадовская В.Д., Килина О.Ю., Зоркальцев М.А., Чойнзонов Е.Л., Чернов В.И., Слонимская Е.М., Богоутдинова А.В., Анисеня И.И., Тицкая А.А., Зельчан Р.В., Фролова И.Г., Сапунова Л.С., Удодов В.Д., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Куражов А.П., Завадовская В.Д., Килина О.Ю., Зоркальцев М.А., Чойнзонов Е.Л., Чернов В.И., Слонимская Е.М., Богоутдинова А.В., Анисеня И.И., Тицкая А.А., Зельчан Р.В., Фролова И.Г., Сапунова Л.С., Удодов В.Д.</copyright-holder><copyright-holder xml:lang="en">Kourazhov A.P., Zavadovskaya V.D., Kilina O.Y., Zorkaltsev M.A., Choinzonov Y.L., Chernov V.I., Slonimskaya Y.M., Bogoutdinova A.V., Anisenya I.I., Titskaya A.A., Zelchan R.V., Frolova I.G., Sapunova L.S., Udodov V.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/505">https://bulletin.ssmu.ru/jour/article/view/505</self-uri><abstract><p>Изучались возможности сцинтиграфии с 199Tl-хлоридом и 99mTc-МИБИ в диагностике воспалительных и опухолевых процессов опорно-двигательного аппарата. Неспецифическая индикация их осуществлена в 92,6 и 98,5% соответственно. Точность сцинтиграфии с 199Tl-хлоридом и 99mTc-МИБИ в диагностике воспаления — 83,7 и 73,2%, опухолей — 88,8 и 75,6% соответственно. Оба маркера пригодны для их индикации, а 199Tl-хлорид — для дифференцирования.</p></abstract><trans-abstract xml:lang="en"><p>Potentialities of 199Tl-chloride and 99mTc-MIBI scintigraphy in diagnostics of musculoskeletal system inflammatory and tumor processes were assessed. Nonspecific indications of inflammations and tumors were obtained in 92.6 и 98.5% respectively. Accuracy 199Tl-chloride and 99mTc-MIBI scintigraphy in diagnostics inflammations were 83.7 and 73.2% respectively, tumors were 88.8 и 75.6% respectively. These markers both are available for indications, and 199Tl-chloride for differentiations of them.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сцинтиграфия</kwd><kwd>199Tl-хлорид</kwd><kwd>99mTc-МИБИ</kwd><kwd>воспалительные процессы</kwd><kwd>опухолевые процессы</kwd><kwd>индекс ретенции</kwd><kwd>диагностическая эффективность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>scintigraphy</kwd><kwd>199Tl-chloride</kwd><kwd>99mTc-MIBI</kwd><kwd>inflammatory processes</kwd><kwd>neoplastic processes</kwd><kwd>retention index</kwd><kwd>diagnostic efficiency</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Завадовская В.Д., Куражов А.П., Килина О.Ю. и др. Дифференциальная диагностика воспалительных и опухолевых процессов опорно-двигательного аппарата с помощью сцинтиграфии с 199Tl-хлоридом // Мед. визуализация. 2009. № 4. С. 55—65.</mixed-citation><mixed-citation xml:lang="en">Завадовская В.Д., Куражов А.П., Килина О.Ю. и др. Дифференциальная диагностика воспалительных и опухолевых процессов опорно-двигательного аппарата с помощью сцинтиграфии с 199Tl-хлоридом // Мед. визуализация. 2009. № 4. С. 55—65.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Куражов А.П., Иванова Т.В., Завадовская В.Д. и др. Сцинтиграфия с 199Tl-хлоридом в диагностике неспецифических воспалительных заболеваний органов малого таза у женщин // Бюл. сиб. медицины. 2005. Т. 4, № 3. С. 86—93.</mixed-citation><mixed-citation xml:lang="en">Куражов А.П., Иванова Т.В., Завадовская В.Д. и др. Сцинтиграфия с 199Tl-хлоридом в диагностике неспецифических воспалительных заболеваний органов малого таза у женщин // Бюл. сиб. медицины. 2005. Т. 4, № 3. С. 86—93.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Федорова О.С., Кузнецова О.Ф., Шатик С.В. и др. Применение 2-[18F]фтор-L-тирозина для дифференцированной диагностики опухолей и очагов воспаления // Материалы науч. конф. «Новые технологии в ядерной медицине», г. Санкт-Петербург. 2006. С. 40.</mixed-citation><mixed-citation xml:lang="en">Федорова О.С., Кузнецова О.Ф., Шатик С.В. и др. Применение 2-[18F]фтор-L-тирозина для дифференцированной диагностики опухолей и очагов воспаления // Материалы науч. конф. «Новые технологии в ядерной медицине», г. Санкт-Петербург. 2006. С. 40.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ballinger J., Sheldon K., Boxen I. et al. Differences between accumulation of 99mTc-MIBI and 201Tl-thallous chloride in tumor cells: role of P-glycoprotein // Q. J. Nucl. Med. 1995. V. 39, № 2. Р. 122—128.</mixed-citation><mixed-citation xml:lang="en">Ballinger J., Sheldon K., Boxen I. et al. Differences between accumulation of 99mTc-MIBI and 201Tl-thallous chloride in tumor cells: role of P-glycoprotein // Q. J. Nucl. Med. 1995. V. 39, № 2. Р. 122—128.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Besset P.R., Hanson M.J., Ozarpechi D.J. Evaluation of postoperative osteomyelitis of the sternum comparing CT and dual 99mTcMDP and 111In WBC SPCT // Clin. Nucl. Med. 1993. V. 18, № 3. P. 197—202.</mixed-citation><mixed-citation xml:lang="en">Besset P.R., Hanson M.J., Ozarpechi D.J. Evaluation of postoperative osteomyelitis of the sternum comparing CT and dual 99mTcMDP and 111In WBC SPCT // Clin. Nucl. Med. 1993. V. 18, № 3. P. 197—202.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kajihara M., Sugawara Y., Hirata M. et al. Extraskeletal osteosarcoma in the thigh: a case report // Radiat. Med. 2005. V. 23, № 2. Р. 142—146.</mixed-citation><mixed-citation xml:lang="en">Kajihara M., Sugawara Y., Hirata M. et al. Extraskeletal osteosarcoma in the thigh: a case report // Radiat. Med. 2005. V. 23, № 2. Р. 142—146.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Love C., Tomas M., Tronco G. et al. FDG PET of infection and inflammation // Radiographics. 2005. V. 25, № 5. Р. 1357—1368.</mixed-citation><mixed-citation xml:lang="en">Love C., Tomas M., Tronco G. et al. FDG PET of infection and inflammation // Radiographics. 2005. V. 25, № 5. Р. 1357—1368.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">McCarville M.B., Barton E.H, Cameron J.R. et al. The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity // Am. J. Roentgenol. 2007. V. 188, № 2. Р. 572—578.</mixed-citation><mixed-citation xml:lang="en">McCarville M.B., Barton E.H, Cameron J.R. et al. The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity // Am. J. Roentgenol. 2007. V. 188, № 2. Р. 572—578.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Nishiyama Y., Yamamoto Y., Fukunaga K. et al. Compari-son of 99Tcm-MIBI with 201Tl chloride SPET in patients with malignant brain tumors // Nucl. Med. Commun. 2001. V. 22. Р. 631—639.</mixed-citation><mixed-citation xml:lang="en">Nishiyama Y., Yamamoto Y., Fukunaga K. et al. Compari-son of 99Tcm-MIBI with 201Tl chloride SPET in patients with malignant brain tumors // Nucl. Med. Commun. 2001. V. 22. Р. 631—639.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Suga K., Nishigauchi K., Fujita T. Difference of thallium-201 kinetics between VX-2 tumors and inflammatory lesions in rabbits // Kaku Igaku. 1994. V. 31, № 2. Р. 151—161.</mixed-citation><mixed-citation xml:lang="en">Suga K., Nishigauchi K., Fujita T. Difference of thallium-201 kinetics between VX-2 tumors and inflammatory lesions in rabbits // Kaku Igaku. 1994. V. 31, № 2. Р. 151—161.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sugawara Y., Kikuchi T., Kajihara M. et al. Thallium-201 scintigraphy in bone and soft-tissue tumors: a comparison of dynamic, early and delayed scans // Ann. Nucl. Med. 2005. V. 19, № 6. P. 461—468.</mixed-citation><mixed-citation xml:lang="en">Sugawara Y., Kikuchi T., Kajihara M. et al. Thallium-201 scintigraphy in bone and soft-tissue tumors: a comparison of dynamic, early and delayed scans // Ann. Nucl. Med. 2005. V. 19, № 6. P. 461—468.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Taki J., Higuchi T., Sumiya H. et al. Prediction of final tu-mor response to preoperative chemotherapy by Tc-99m MIBI imaging at the middle of chemotherapy in malignant bone and soft tissue tumors: comparison with Tl-201 ima¬ging // J. Orthop. Res. 2008. V. 26, № 3. P. 411—418.</mixed-citation><mixed-citation xml:lang="en">Taki J., Higuchi T., Sumiya H. et al. Prediction of final tu-mor response to preoperative chemotherapy by Tc-99m MIBI imaging at the middle of chemotherapy in malignant bone and soft tissue tumors: comparison with Tl-201 ima¬ging // J. Orthop. Res. 2008. V. 26, № 3. P. 411—418.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
