ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2023-4-164-173ssmu-5433Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESДисбаланс адипокинов и его роль в патогенезе новой коронавирусной инфекцииAdipokine imbalance and its role in the pathogenesis of novel coronavirus infectionhttps://orcid.org/0000-0002-4513-6329БеспаловаИ. Д.BespalovaI. D.

Беспалова Инна Давидовна – д-р мед. наук, зав. кафедрой пропедевтики внутренних болезней с курсом терапии педиатрического факультета

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

innadave@mail2000.ruhttps://orcid.org/0000-0001-6091-4849МитриченкоУ. М.MitrichenkoU. M.

Митриченко Ульяна Михайловна – аспирант, кафедра пропедевтики внутренних болезней с курсом терапии педиатрического факультета

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

strashkovaum@gmail.comhttps://orcid.org/0000-0001-9640-2028КалюжинВ. В.KalyuzhinV. V.

Калюжин Вадим Витальевич – д-р мед. наук, профессор, зав. кафедрой госпитальной терапии с курсом реабилитации, физиотерапии и спортивной медицины

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

kalyuzhinvv@mail.ruhttps://orcid.org/0000-0003-1911-166XКоролеваЕ. С.KorolevaE. S.

Королева Екатерина Сергеевна – д-р мед. наук, профессор, кафедра неврологии и нейрохирургии

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

kattorina@list.ruhttps://orcid.org/0000-0001-5260-4832КощавцеваЮ. И.KoshchavtsevaYu. I.

Кощавцева Юлия Игоревна – ассистент, кафедра пропедевтики внутренних болезней с курсом терапии педиатрического факультета

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

kossy09@mail.ruhttps://orcid.org/0009-0002-2028-4963РомановД. С.RomanovD. S.

Романов Дмитрий Сергеевич – аспирант, кафедра пропедевтики внутренних болезней с курсом терапии педиатрического факультета

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

romanovds92@yandex.ruhttps://orcid.org/0000-0003-3202-4579ПершинаД. Е.PershinaD. E.

Першина Диана Евгеньевна – студентка, педиатрический факультет

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

dianapershina2000@gmail.comСибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical UniversityRussian Federation202324012024224164173Copyright © Беспалова И.Д., Митриченко У.М., Калюжин В.В., Королева Е.С., Кощавцева Ю.И., Романов Д.С., Першина Д.Е., 20242024Беспалова И.Д., Митриченко У.М., Калюжин В.В., Королева Е.С., Кощавцева Ю.И., Романов Д.С., Першина Д.Е.Bespalova I.D., Mitrichenko U.M., Kalyuzhin V.V., Koroleva E.S., Koshchavtseva Y.I., Romanov D.S., Pershina D.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/5433

В обзоре обобщены и проанализированы результаты крупных зарубежных исследований, касающихся изучения роли адипокинового дисбаланса в развитии тяжелого течения и осложнений новой коронавирусной инфекции (COVID-19). Адипокины – биологически активные соединения, которые вырабатываются клетками жировой ткани и участвуют в регуляции обмена веществ и работы иммунной системы.

Известно, что ожирение является доказанным фактором риска тяжелого течения COVID-19 в связи с высокой гормональной и метаболической активностью висцеральной жировой ткани. Глубокое понимание патогенеза COVID-19 с позиций участия в нем адипокинового дисбаланса может лечь в основу разработки эффективных патогенетических подходов к профилактике тяжелого течения и осложнений новой коронавирусной инфекции.

The review summarizes and analyzes the results of major foreign studies on the role of adipokine imbalance in the development of a severe course and complications of novel coronavirus infection (COVID-19). Adipokines are biologically active compounds produced by adipose tissue cells and involved in the regulation of metabolism and the functioning of the immune system. 

Obesity is a proven risk factor for severe COVID-19 due to high hormonal and metabolic activity of visceral adipose tissue. A deep understanding of COVID-19 pathogenesis from the point of view of the role of adipokine imbalance in it can provide the grounds for the development of effective pathogenetic approaches to the prevention of a severe course and complications of novel coronavirus infection.

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The authors declare that there are no conflicts of interest present.