ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2024-1-126-133ssmu-5535Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРоль звездчатых клеток в формировании ниши прогениторных клеток печениHepatic stellate cells and their role in the formation of the progenitor cell nichehttps://orcid.org/0000-0002-9516-0204ЖдановВ. В.ZhdanovV. V.

Жданов Вадим Вадимович – д-р мед. наук, чл.-корр. РАН, директор

634028, г. Томск, пр. Ленина, 3

3, Lenina Av., Tomsk, 634028

hdanov_vv@pharmso.ruhttps://orcid.org/0000-0003-4398-9122ЧайковскийА. В.ChaikovskiiA. V.

Чайковский Александр Васильевич – канд. мед. наук, науч. сотрудник, лаборатория патофизиологии и экспериментальной терапии

634028, г. Томск, пр. Ленина, 3

3, Lenina Av., Tomsk, 634028

thav_pharm@mail.ruhttps://orcid.org/0000-0002-2163-7647ПанЭ. С.PanE. S.

Пан Эдгар Сергеевич – канд. биол. наук, ст. науч. сотрудник, лаборатория регуляции репаративных процессов

125315, г. Москва, ул. Балтийская, 8

8, Baltiyskaya Str., Moscow, 125315

artifexpan@gmail.comНаучно-исследовательский институт фармакологии и регенеративной медицины (НИИФиРМ) им. Е.Д. Гольдберга, Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукРоссияGoldberg Research Institute of Pharmacology and Regenerative Medicine (GRIPRM), Tomsk National Research Medical Center (NRMC) of the Russian Academy of SciencesRussian FederationНаучно-исследовательский институт общей патологии и патофизиологии (НИИОПП)РоссияResearch Institute of General Pathology and PathophysiologyRussian Federation202411042024231126133Copyright © Жданов В.В., Чайковский А.В., Пан Э.С., 20242024Жданов В.В., Чайковский А.В., Пан Э.С.Zhdanov V.V., Chaikovskii A.V., Pan E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/5535

Процессы пролиферации и дифференцировки прогениторных/стволовых клеток в организме обеспечиваются специфическим микроокружением – нишей стволовых клеток. Для всех ниш определены универсальные компоненты – поддерживающие клетки, внеклеточный матрикс и растворимые биологические факторы. Ниша является динамической системой, активность которой зависит от запросов регенерации.

В обзоре представлены данные о строении ниши стволовых клеток печени, одном из ее основных компонентов – звездчатых клетках и их роли в патологии.

The processes of proliferation and differentiation of progenitor and stem cells in the body are ensured by a specific microenvironment, the stem cell niche. Universal components have been identified for all niches: supporting cells, extracellular matrix, and soluble biological factors. A niche is a dynamic system whose activity depends on regeneration needs.

The review presents data on the structure of the hepatic stem cell niche and one of its main components – stellate cells and their role in pathology.

 

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The authors declare that there are no conflicts of interest present.