<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2024-2-114-122</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-5668</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Синдром старческой астении и его особенности при болезни Паркинсона</article-title><trans-title-group xml:lang="en"><trans-title>Syndrome frailty and his features in Parkinson’s disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8659-9832</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Guseva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гусева Ольга Владимировна – канд. мед. наук, доцент, кафедра госпитальной терапии с курсом реабилитации, физиотерапии и спортивной медицин; врач лечебной физкультуры, отделение физиотерапии </p><p>634050, Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>2, Moscow Тrakt, Tomsk, 634050</p></bio><email xlink:type="simple">gusolvl@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет (СибГМУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>10</day><month>07</month><year>2024</year></pub-date><volume>23</volume><issue>2</issue><fpage>114</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гусева О.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Гусева О.В.</copyright-holder><copyright-holder xml:lang="en">Guseva O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/5668">https://bulletin.ssmu.ru/jour/article/view/5668</self-uri><abstract><p>Синдром старческой астении распространен во всем мире, и его появление связано с увеличением продолжительности жизни. В лекции показаны мультифакторность формирования синдрома: изменения физического здоровья, социальные и психологические факторы, а также гендерные особенности и влияние возраста. Классическая диагностика синдрома состоит в оценке физической слабости по фенотипу Фрайд. Современный взгляд на проблему дополняет диагностику индексами слабости для характеристики мультифакторности развития и применением цифровых носимых технологий для длительного мониторирования функциональных показателей пациента. Дано развернутое обоснование влияния коморбидности на развитие старческой астении. Особенностью синдрома старческой астении при болезни Паркинсона является трудность его диагностики при возможно высокой распространенности. Исследования старческой астении при болезни Паркинсона малочисленны, вероятно, из-за схожести симптомов болезни и синдрома. Определены возможные риски возникновения старческой астении при болезни Паркинсона: влияние различных форм болезни Паркинсона, пола, когнитивных и функциональных нарушений, полипрагмазии, дозы леводопы. Показана роль комплексной мультидисциплинарной реабилитации и самостоятельной физической активности при сочетании болезни Паркинсона и синдрома старческой астении.</p></abstract><trans-abstract xml:lang="en"><p>Syndrome frailty is widespread all over the world and its appearance is associated with an increase in life expectancy. The lecture shows the multifactorial nature of the syndrome: changes in physical health, social and psychological factors, gender characteristics and age. The classic diagnosis of the syndrome consists in assessing physical weakness according to the Fried phenotype. The modern view of the problem complements the diagnosis with indices of weakness to characterize the multifactorial development and the use of digital wearable technologies for long-term monitoring of the patient’s functional parameters.The lecture provides a detailed justification of the effect of comorbidity on the development of syndrome frailty. The syndrome frailty is difficult diagnosed in Parkinson’s disease, because it has high prevalence in these. Studies of syndrome frailty in Parkinson’s disease are few, probably due to the similarity of the symptoms of the disease and the syndrome. The lecture identifies the possible risks of syndrome frailty in Parkinson’s disease: the influence of various forms of Parkinson’s disease, gender, cognitive and functional disorders, polypharmacy, levodopa doses. The role of multidisciplinary rehabilitation’s team and independent physical activity in the combination of Parkinson’s disease and syndrome frailty is shown.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром старческой астении</kwd><kwd>диагностика</kwd><kwd>коморбидность</kwd><kwd>болезнь Паркинсона</kwd></kwd-group><kwd-group xml:lang="en"><kwd>syndrome frailty</kwd><kwd>diagnosis</kwd><kwd>comorbidity</kwd><kwd>Parkinson’s disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chen X., Giles J., Yao Y., Yip W., Meng Q., Berkman L. et al. The path to healthy ageing in China: a Peking University-Lancet Commission. Lancet. 2022;400(10367):1967–2006. DOI: 10.1016/S0140-6736(22)01546-X.</mixed-citation><mixed-citation xml:lang="en">Chen X., Giles J., Yao Y., Yip W., Meng Q., Berkman L. et al. The path to healthy ageing in China: a Peking University-Lancet Commission. Lancet. 2022;400(10367):1967–2006. DOI: 10.1016/S0140-6736(22)01546-X.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Melo Filho J., Moreira N.B., Vojciechowski A.S., Biesek S., Bento P.C.B., Gomes A.R.S. Frailty prevalence and related factors in older adults from southern Brazil: A cross-sectional observational study. Clinics. 2020;75:e1694. DOI: 10.6061/clinics/2020/e1694.</mixed-citation><mixed-citation xml:lang="en">Melo Filho J., Moreira N.B., Vojciechowski A.S., Biesek S., Bento P.C.B., Gomes A.R.S. Frailty prevalence and related factors in older adults from southern Brazil: A cross-sectional observational study. Clinics. 2020;75:e1694. DOI: 10.6061/clinics/2020/e1694.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Palermo S., Stanziano M., Nigri A., Civilotti C., Celeghin A. Parkinson’s disease, SARS-CoV-2, and frailty: is there a vicious cycle related to hypovitaminosis D? Brain Sciences. 2023;13:528. DOI: 10.3390/brainsci13040528.</mixed-citation><mixed-citation xml:lang="en">Palermo S., Stanziano M., Nigri A., Civilotti C., Celeghin A. Parkinson’s disease, SARS-CoV-2, and frailty: is there a vicious cycle related to hypovitaminosis D? Brain Sciences. 2023;13:528. DOI: 10.3390/brainsci13040528.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kaczorowska A., Szwamel K., Fortuna M., Mroczek A., Lepsy E., Katan A. Assessment of physical fitness and risk factors for the occurrence of the frailty syndrome among social welfare homes’ residents over 60 years of age in Poland. Intl. J. Environl. Res. Public Health. 2022;19:7449. DOI: 10.3390/ijerph19127449.</mixed-citation><mixed-citation xml:lang="en">Kaczorowska A., Szwamel K., Fortuna M., Mroczek A., Lepsy E., Katan A. Assessment of physical fitness and risk factors for the occurrence of the frailty syndrome among social welfare homes’ residents over 60 years of age in Poland. Intl. J. Environl. Res. Public Health. 2022;19:7449. DOI: 10.3390/ijerph19127449.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Boissonneault M., Rios P. Changes in healthy and unhealthy working-life expectancy over the period 2002–17: a population-based study in people aged 51–65 years in 14 OECD countries. The Lancet Healthy Longevity. 2021;2(10):e629–e638. DOI: 10.1016/s2666-7568(21)00202-6.</mixed-citation><mixed-citation xml:lang="en">Boissonneault M., Rios P. Changes in healthy and unhealthy working-life expectancy over the period 2002–17: a population-based study in people aged 51–65 years in 14 OECD countries. The Lancet Healthy Longevity. 2021;2(10):e629–e638. DOI: 10.1016/s2666-7568(21)00202-6.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen T.T.H., Nguyen A.T., Vu T.-H.T., Dau N.T., Nguyen P.Q., Nguyen T.X. et al. Association of frailty status and functional disability among community-dwelling people aged 80 and older in Vietnam. BioMed Res. Int. 2021;e7109452:1–6. DOI: 10.1155/2021/7109452.</mixed-citation><mixed-citation xml:lang="en">Nguyen T.T.H., Nguyen A.T., Vu T.-H.T., Dau N.T., Nguyen P.Q., Nguyen T.X. et al. Association of frailty status and functional disability among community-dwelling people aged 80 and older in Vietnam. BioMed Res. Int. 2021;e7109452:1–6. DOI: 10.1155/2021/7109452.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ahrenfeldt L.J., Möller S., Thinggaard M., Christensen K., Lindahl-Jacobsen R. Sex differences in comorbidity and frailty in Europe. Int. J. Public Health. 2019;64(7):1025–1036. DOI: 10.1007/s00038-019-01270-9.</mixed-citation><mixed-citation xml:lang="en">Ahrenfeldt L.J., Möller S., Thinggaard M., Christensen K., Lindahl-Jacobsen R. Sex differences in comorbidity and frailty in Europe. Int. J. Public Health. 2019;64(7):1025–1036. DOI: 10.1007/s00038-019-01270-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sousa-Fraguas M.C., Rodríguez-Fuentes G., Conejo N.N. Frailty and cognitive impairment in Parkinson’s disease: a systematic review. J. Neur. Sci. 2022;43(12):6693–6706. DOI: 10.1007/s10072-022-06347-7.</mixed-citation><mixed-citation xml:lang="en">Sousa-Fraguas M.C., Rodríguez-Fuentes G., Conejo N.N. Frailty and cognitive impairment in Parkinson’s disease: a systematic review. J. Neur. Sci. 2022;43(12):6693–6706. DOI: 10.1007/s10072-022-06347-7.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Salaffi F., De Angelis R., Farah S., Carotti M., Di Carlo M. Frailty as a novel predictor of achieving comprehensive disease control (CDC) in rheumatoid arthritis. Clin. Rheumatol. 2021;40:4869–4877. DOI: 10.1007/s10067-021-05744-1.</mixed-citation><mixed-citation xml:lang="en">Salaffi F., De Angelis R., Farah S., Carotti M., Di Carlo M. Frailty as a novel predictor of achieving comprehensive disease control (CDC) in rheumatoid arthritis. Clin. Rheumatol. 2021;40:4869–4877. DOI: 10.1007/s10067-021-05744-1.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Clegg A., Young J., Iliffe S., Rikker M.O., Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. DOI: 10.1016/s0140-6736(12)62167-9.</mixed-citation><mixed-citation xml:lang="en">Clegg A., Young J., Iliffe S., Rikker M.O., Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. DOI: 10.1016/s0140-6736(12)62167-9.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis l. How can identifying and grading frailty support older people in acute and community settings? Nurs. Older People. 2020;32(6):e1271. DOI: 10.7748/nop.2020.e1271.</mixed-citation><mixed-citation xml:lang="en">Lewis l. How can identifying and grading frailty support older people in acute and community settings? Nurs. Older People. 2020;32(6):e1271. DOI: 10.7748/nop.2020.e1271.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Park C., Ko F.C. The Science of frailty: sex differences. Clin. Geriatr. Medi. 2021;37(4):625–638. DOI: 10.1016/j.cger.2021.05.008.</mixed-citation><mixed-citation xml:lang="en">Park C., Ko F.C. The Science of frailty: sex differences. Clin. Geriatr. Medi. 2021;37(4):625–638. DOI: 10.1016/j.cger.2021.05.008.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Roland K., Cornett K., Theou O., Jakobi J., Jones G. Physical activity across frailty phenotypes in females with Parkinson’s disease. J. Aging Res. 2012;e468156:1–8. DOI: 10.1155/2012/468156.</mixed-citation><mixed-citation xml:lang="en">Roland K., Cornett K., Theou O., Jakobi J., Jones G. Physical activity across frailty phenotypes in females with Parkinson’s disease. J. Aging Res. 2012;e468156:1–8. DOI: 10.1155/2012/468156.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ozer F., Akin S., Gultekin M., Erturkzararsiz G., Soylu A. Frailty in patients with Parkinson’s disease: associations with disability and Timed Up and Go. Arch. Neuropsychiatry. 2019;58:206–212. DOI: 10.29399/npa.23444.</mixed-citation><mixed-citation xml:lang="en">Ozer F., Akin S., Gultekin M., Erturkzararsiz G., Soylu A. Frailty in patients with Parkinson’s disease: associations with disability and Timed Up and Go. Arch. Neuropsychiatry. 2019;58:206–212. DOI: 10.29399/npa.23444.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bartoli M., Palermo S., Cipriani G., Amanzio M. A possible association between executive dysfunction and frailty in patients with neurocognitive disorders. Front. Psychol. 2020;11:e554307. DOI: 10.3389/fpsyg.2020.554307.</mixed-citation><mixed-citation xml:lang="en">Bartoli M., Palermo S., Cipriani G., Amanzio M. A possible association between executive dysfunction and frailty in patients with neurocognitive disorders. Front. Psychol. 2020;11:e554307. DOI: 10.3389/fpsyg.2020.554307.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Panhwar Y., Naghdy F., Naghdy G., Stirling D., Potter J. Assessment of frailty: a survey of quantitative and clinical methods. BMC Biomedical Engineering. 2019:1(1):1–20. DOI: 10.1186/s42490-019-0007-y.</mixed-citation><mixed-citation xml:lang="en">Panhwar Y., Naghdy F., Naghdy G., Stirling D., Potter J. Assessment of frailty: a survey of quantitative and clinical methods. BMC Biomedical Engineering. 2019:1(1):1–20. DOI: 10.1186/s42490-019-0007-y.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cobo A., Villalba-Mora E., Pérez-Rodríguez R., Ferre X., Rodríguez-Mañas L. Unobtrusive sensors for the assessment of older adult’s frailty: A Scoping review. Sensors. 2021;21(9):2983. DOI: 10.3390/s21092983.</mixed-citation><mixed-citation xml:lang="en">Cobo A., Villalba-Mora E., Pérez-Rodríguez R., Ferre X., Rodríguez-Mañas L. Unobtrusive sensors for the assessment of older adult’s frailty: A Scoping review. Sensors. 2021;21(9):2983. DOI: 10.3390/s21092983.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar D., Toosizadeh N., Mohler J., Ehsani H., Mannier C., Laksari K. Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment. BMC Geriatr. 2020;20(1):164. DOI: 10.1186/s12877-020-01572-1.</mixed-citation><mixed-citation xml:lang="en">Kumar D., Toosizadeh N., Mohler J., Ehsani H., Mannier C., Laksari K. Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment. BMC Geriatr. 2020;20(1):164. DOI: 10.1186/s12877-020-01572-1.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pernas F., Carrasco-Ribelles L., Abellana R., Roso-Llorach A., Cegri F., Reyes C., Violán C. Validation of an electronic frailty index with electronic health records: eFRAGICAP index. BMC Geriatric. 2022;22:404. DOI: 10.21203/rs.3.rs-1368757/v1.</mixed-citation><mixed-citation xml:lang="en">Pernas F., Carrasco-Ribelles L., Abellana R., Roso-Llorach A., Cegri F., Reyes C., Violán C. Validation of an electronic frailty index with electronic health records: eFRAGICAP index. BMC Geriatric. 2022;22:404. DOI: 10.21203/rs.3.rs-1368757/v1.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Zahir M., Wang C., Gardea M., Nguyen H., Shahbazi M., Sharafkhaneh A., Ruiz I.T. et al. Remote physical monitoring – the application of deep learning-based pimage processing in tele-health. IEEE Access. 2020;8:219391–219399. DOI: 10.1109/access.2020.3042451.</mixed-citation><mixed-citation xml:lang="en">Zahir M., Wang C., Gardea M., Nguyen H., Shahbazi M., Sharafkhaneh A., Ruiz I.T. et al. Remote physical monitoring – the application of deep learning-based pimage processing in tele-health. IEEE Access. 2020;8:219391–219399. DOI: 10.1109/access.2020.3042451.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ma L., Chan P. Understanding the physiological links between physical frailty and cognitive decline. Aging Dis. 2020;11(2):405–418. DOI: 10.14336/AD.2019.0521.</mixed-citation><mixed-citation xml:lang="en">Ma L., Chan P. Understanding the physiological links between physical frailty and cognitive decline. Aging Dis. 2020;11(2):405–418. DOI: 10.14336/AD.2019.0521.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rahman M.M., Mim S.A., Islam M.R., Parvez A., Islam F., Uddin M.B. et al. Exploring the recent trends in management of dementia and frailty: focus on diagnosis and treatment. Curr. Med. Chem. 2022;29(32):5289–5314. DOI: 10.2174/0929867329666220408102051.</mixed-citation><mixed-citation xml:lang="en">Rahman M.M., Mim S.A., Islam M.R., Parvez A., Islam F., Uddin M.B. et al. Exploring the recent trends in management of dementia and frailty: focus on diagnosis and treatment. Curr. Med. Chem. 2022;29(32):5289–5314. DOI: 10.2174/0929867329666220408102051.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Peng S., Zhou J., Xiong S., Liu X., Pei M., Wang Y. et al. Construction and validation of cognitive frailty risk prediction model for elderly patients with multimorbidity in Chinese community based on non-traditional factors. BMC Psychiatry. 2023;23:266. DOI: 10.1186/s12888-023-04736-6.</mixed-citation><mixed-citation xml:lang="en">Peng S., Zhou J., Xiong S., Liu X., Pei M., Wang Y. et al. Construction and validation of cognitive frailty risk prediction model for elderly patients with multimorbidity in Chinese community based on non-traditional factors. BMC Psychiatry. 2023;23:266. DOI: 10.1186/s12888-023-04736-6.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tse M.M.Y., Kwan R.Y.C., Ho S.S.M., Davidson P.M.D., Cheng P.P.P., Yeung S.S.Y. Frailty is associated with pain and cognitive function in older people in post-acute care settings. Geriatr. Nurs. 2020;41(5):530–535. DOI: 10.1016/j.gerinurse.2019.04.001.</mixed-citation><mixed-citation xml:lang="en">Tse M.M.Y., Kwan R.Y.C., Ho S.S.M., Davidson P.M.D., Cheng P.P.P., Yeung S.S.Y. Frailty is associated with pain and cognitive function in older people in post-acute care settings. Geriatr. Nurs. 2020;41(5):530–535. DOI: 10.1016/j.gerinurse.2019.04.001.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Park J., Kim W.J. Potential imaging biomarkers of cognitive frailty. Annals of Geriatric Medicine and Research. 2023;27(1):3–8. DOI: 10.4235/agmr.22.014137.</mixed-citation><mixed-citation xml:lang="en">Park J., Kim W.J. Potential imaging biomarkers of cognitive frailty. Annals of Geriatric Medicine and Research. 2023;27(1):3–8. DOI: 10.4235/agmr.22.014137.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kocyigit S., Soysal P., Bulut E., Aydin E., Dokuzlar O. What is the relationship between frailty and orthostatic hypotension in older adults? J. Geriatr. Cardiol. 2019;16:272–279. DOI: 10.11909/j.issn.1671-5411.2019.03.005.</mixed-citation><mixed-citation xml:lang="en">Kocyigit S., Soysal P., Bulut E., Aydin E., Dokuzlar O. What is the relationship between frailty and orthostatic hypotension in older adults? J. Geriatr. Cardiol. 2019;16:272–279. DOI: 10.11909/j.issn.1671-5411.2019.03.005.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mol A., Slangen R.L.N., Trappenburg M.C., Reijnierse E.M., van Wezel R.J.A., Meskers C.G.M. et al. Blood pressure drop rate after standing up is associated with frailty and number of falls in geriatric outpatients. J. Am. Heart Ass. 2020;9(7):014688. DOI: 10.1161/jaha.119.014688.</mixed-citation><mixed-citation xml:lang="en">Mol A., Slangen R.L.N., Trappenburg M.C., Reijnierse E.M., van Wezel R.J.A., Meskers C.G.M. et al. Blood pressure drop rate after standing up is associated with frailty and number of falls in geriatric outpatients. J. Am. Heart Ass. 2020;9(7):014688. DOI: 10.1161/jaha.119.014688.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ardolino I., Franchi C., Nobili A., Mannucci P.M., Corli O. Pain and frailty in hospitalized older adults. Pain Therap. 2020;9:727–740. DOI: 10.1007/s 40122-020-00202-3.</mixed-citation><mixed-citation xml:lang="en">Ardolino I., Franchi C., Nobili A., Mannucci P.M., Corli O. Pain and frailty in hospitalized older adults. Pain Therap. 2020;9:727–740. DOI: 10.1007/s 40122-020-00202-3.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Collard R.M., Comijs H.C., Naarding P., Penninx B.W., Milaneschi Y., Ferrucci L. et al. Frailty as a predictor of the incidence and course of depressed mood. J. Am. Med. Directors Ass. 2015;16(6):509–514. DOI: 10.1016/j.jamda.2015.01.088.</mixed-citation><mixed-citation xml:lang="en">Collard R.M., Comijs H.C., Naarding P., Penninx B.W., Milaneschi Y., Ferrucci L. et al. Frailty as a predictor of the incidence and course of depressed mood. J. Am. Med. Directors Ass. 2015;16(6):509–514. DOI: 10.1016/j.jamda.2015.01.088.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Oyon J., Serra-Prat M., Ferrer M., Linares A., Pastor N., Limón E. et al. Psychosocial factors associated with frailty in the community-dwelling aged population with depression. A cross-sectional study. Atención Primaria. 2021;53(5):e102048. DOI: 10.1016/j.aprim.2021.102048.</mixed-citation><mixed-citation xml:lang="en">Oyon J., Serra-Prat M., Ferrer M., Linares A., Pastor N., Limón E. et al. Psychosocial factors associated with frailty in the community-dwelling aged population with depression. A cross-sectional study. Atención Primaria. 2021;53(5):e102048. DOI: 10.1016/j.aprim.2021.102048.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Atkins J., Jylhävä J., Pedersen N.L., Magnusson P.K., Lu Y., Wang Y. et al. A genome‐wide association study of the frailty index highlights brain pathways in ageing. Aging Cell. 2021;20(9):e13459. DOI: 10.1111/acel.13459.</mixed-citation><mixed-citation xml:lang="en">Atkins J., Jylhävä J., Pedersen N.L., Magnusson P.K., Lu Y., Wang Y. et al. A genome‐wide association study of the frailty index highlights brain pathways in ageing. Aging Cell. 2021;20(9):e13459. DOI: 10.1111/acel.13459.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Sathyan S., Barzilai N., Atzmon G., Milman S., Ayers E., Verghese J. Genetic insights into frailty: association of 9p21-23 locus with frailty. Front. in Med. 2018;5:e105. DOI: 10.3389/fmed.2018.00105.</mixed-citation><mixed-citation xml:lang="en">Sathyan S., Barzilai N., Atzmon G., Milman S., Ayers E., Verghese J. Genetic insights into frailty: association of 9p21-23 locus with frailty. Front. in Med. 2018;5:e105. DOI: 10.3389/fmed.2018.00105.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">McMillan J.M., Michalchuk Q., Goodarzi Z. Frailty in Parkinson’s disease: a systematic review and meta-analysis. Clin. Park &amp; Related Disord. 2021;4:e100095. DOI: 10.1016/j.prdoa.2021.100095.</mixed-citation><mixed-citation xml:lang="en">McMillan J.M., Michalchuk Q., Goodarzi Z. Frailty in Parkinson’s disease: a systematic review and meta-analysis. Clin. Park &amp; Related Disord. 2021;4:e100095. DOI: 10.1016/j.prdoa.2021.100095.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Tenison E., Henderson E.J. Multimorbidity and frailty: tackling complexity in Parkinson’s disease. J. Parkinson’s Dis. 2020;10(s1):85–91. DOI: 10.3233/jpd-202105.</mixed-citation><mixed-citation xml:lang="en">Tenison E., Henderson E.J. Multimorbidity and frailty: tackling complexity in Parkinson’s disease. J. Parkinson’s Dis. 2020;10(s1):85–91. DOI: 10.3233/jpd-202105.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Abraham D.S., Nguyen T.PP., Willis A.W. Claims‐based frailty and outcomes: applying an aging measure to older adults with Parkinson’s disease. Mov. Disord. 2021;36(8):1871–1878. DOI: 10.1002/mds.28561.</mixed-citation><mixed-citation xml:lang="en">Abraham D.S., Nguyen T.PP., Willis A.W. Claims‐based frailty and outcomes: applying an aging measure to older adults with Parkinson’s disease. Mov. Disord. 2021;36(8):1871–1878. DOI: 10.1002/mds.28561.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Wang C.-K., Chen H.-L., Lu C.-H., Chen M.-H., Chiang P.-L., Cheb Y.-S. et al. Altered body composition of psoas and thigh muscles in relation to frailty and severity of Parkinson’s disease. Inter. J. Environ Res. Pub. Health. 2019;16(19):e3667. DOI: 3390/ijerph16193667.</mixed-citation><mixed-citation xml:lang="en">Wang C.-K., Chen H.-L., Lu C.-H., Chen M.-H., Chiang P.-L., Cheb Y.-S. et al. Altered body composition of psoas and thigh muscles in relation to frailty and severity of Parkinson’s disease. Inter. J. Environ Res. Pub. Health. 2019;16(19):e3667. DOI: 3390/ijerph16193667.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Jiménez-Cebrián A.M., Becerro-de-Bengoa-Vallejo R., Losa-Iglesias M.E., de Labra C., Calvo-Lobo C., Palomo-López P. et al. Kinesiophobia levels in patients with Parkinson’s disease: a case-control investigation. Inter. J. Environ Res. Pub. Health. 2021;18(9):e4791. DOI: 10.3390/ijerph18094791.</mixed-citation><mixed-citation xml:lang="en">Jiménez-Cebrián A.M., Becerro-de-Bengoa-Vallejo R., Losa-Iglesias M.E., de Labra C., Calvo-Lobo C., Palomo-López P. et al. Kinesiophobia levels in patients with Parkinson’s disease: a case-control investigation. Inter. J. Environ Res. Pub. Health. 2021;18(9):e4791. DOI: 10.3390/ijerph18094791.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Figueroa C.A., Rosen C.J. Parkinson’s disease and osteoporosis: basic and clinical implications. Expert Rev. Endocrinol. Metab. 2020;15(3):185–193. DOI: 10.1080/17446651.2020.1756772.</mixed-citation><mixed-citation xml:lang="en">Figueroa C.A., Rosen C.J. Parkinson’s disease and osteoporosis: basic and clinical implications. Expert Rev. Endocrinol. Metab. 2020;15(3):185–193. DOI: 10.1080/17446651.2020.1756772.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Lin W.-C., Huang Y.-C., Leong C.-P., Chen M.-H., Chen H.-L., Tsai N.-W. et al. Associations between cognitive functions and physical frailty in patients with Parkinson’s disease. Front. Aging Neurosci. 2019;11:283. DOI: 10.3389/fnagi.2019.00283.</mixed-citation><mixed-citation xml:lang="en">Lin W.-C., Huang Y.-C., Leong C.-P., Chen M.-H., Chen H.-L., Tsai N.-W. et al. Associations between cognitive functions and physical frailty in patients with Parkinson’s disease. Front. Aging Neurosci. 2019;11:283. DOI: 10.3389/fnagi.2019.00283.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Taguchi C.K., de Lemos Menezes P., Melo A.C.S., de Santana L.S., Conceição W.R.S., de Souza G.F. et al. Frailty syndrome and risks for falling in the elderly community. Codas. 2022;34(6):e20210025. DOI: 10.1590/2317-1782/20212021 025en.</mixed-citation><mixed-citation xml:lang="en">Taguchi C.K., de Lemos Menezes P., Melo A.C.S., de Santana L.S., Conceição W.R.S., de Souza G.F. et al. Frailty syndrome and risks for falling in the elderly community. Codas. 2022;34(6):e20210025. DOI: 10.1590/2317-1782/20212021 025en.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Baba Y., Putzke J.D., Whaley N.R., Wszolek Z.K., Uitt R.J. Gender and the Parkinson’s disease phenotype. J. Neurol. 2005;252(10):1201–1205. DOI: 10.1007/s00415-005-0835-7.</mixed-citation><mixed-citation xml:lang="en">Baba Y., Putzke J.D., Whaley N.R., Wszolek Z.K., Uitt R.J. Gender and the Parkinson’s disease phenotype. J. Neurol. 2005;252(10):1201–1205. DOI: 10.1007/s00415-005-0835-7.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hrytsuliak B., Ostapiak Z., Polataiko Y., Herych R., Lisovskyi B., Lapkovskyi E. et al. Dynamics of balance indicators, activities of daily living, and quality of life of elderly suffering from Parkinson’s disease and frailty after proximal humerus fracture following physiotherapeutic functional training. J. Med. Life. 2022;15(1):98–103. DOI: 10.25122/jml-2021-0386.</mixed-citation><mixed-citation xml:lang="en">Hrytsuliak B., Ostapiak Z., Polataiko Y., Herych R., Lisovskyi B., Lapkovskyi E. et al. Dynamics of balance indicators, activities of daily living, and quality of life of elderly suffering from Parkinson’s disease and frailty after proximal humerus fracture following physiotherapeutic functional training. J. Med. Life. 2022;15(1):98–103. DOI: 10.25122/jml-2021-0386.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Yokote A., Hayashi Y., Yanamoto S., Fujioka S., Higa K., Tsuboi Y. Leg muscle strength correlates with gait performance in advanced Parkinson disease. Int. Med. 2022;61(5):633–638. DOI: 10.2169/internalmedicine.7646-21.</mixed-citation><mixed-citation xml:lang="en">Yokote A., Hayashi Y., Yanamoto S., Fujioka S., Higa K., Tsuboi Y. Leg muscle strength correlates with gait performance in advanced Parkinson disease. Int. Med. 2022;61(5):633–638. DOI: 10.2169/internalmedicine.7646-21.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Álvarez-Bustos A., Rodríguez-Sánchez B., Carnicero-Carreño J.A., Sepúlveda-Loyola W., Garcia-Garcia F.J., Rodríguez-Mañas L. Healthcare cost expenditures associated to frailty and sarcopenia. BMC Geriatr. 2022;(22):747. DOI: 10.1186/s12877-022-03439-z.</mixed-citation><mixed-citation xml:lang="en">Álvarez-Bustos A., Rodríguez-Sánchez B., Carnicero-Carreño J.A., Sepúlveda-Loyola W., Garcia-Garcia F.J., Rodríguez-Mañas L. Healthcare cost expenditures associated to frailty and sarcopenia. BMC Geriatr. 2022;(22):747. DOI: 10.1186/s12877-022-03439-z.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen C.J., Benyaminov R., Rahman M., Ngu D., Reinhardt M. Frailty. Med. Clin. North Am. 2023;107(1);183–197. DOI: 10.1016/j.mcna.2022.04.006.</mixed-citation><mixed-citation xml:lang="en">Cohen C.J., Benyaminov R., Rahman M., Ngu D., Reinhardt M. Frailty. Med. Clin. North Am. 2023;107(1);183–197. DOI: 10.1016/j.mcna.2022.04.006.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Spiers G.F., Kunonga T.P., Hall A., Beyer F., Boulton E., Parker S. et al. Measuring frailty in younger populations: a rapid review of evidence. BMJ. Open. 2021;11:e047051. DOI: 10.1136/bmjopen-2020-047051.</mixed-citation><mixed-citation xml:lang="en">Spiers G.F., Kunonga T.P., Hall A., Beyer F., Boulton E., Parker S. et al. Measuring frailty in younger populations: a rapid review of evidence. BMJ. Open. 2021;11:e047051. DOI: 10.1136/bmjopen-2020-047051.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
