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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2012-4-171-172</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-571</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SHORT MESSAGES</subject></subj-group></article-categories><title-group><article-title>Предикторы неудачи в лечении по программе DOTS-PLUS у пациентов, страдающих множественно лекарственно-устойчивым туберкулезом</article-title><trans-title-group xml:lang="en"><trans-title>Predictors of failure in treatment according program DOTS-PLUS in patients suffering from multidrug-resistant tuberculosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фелькер</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Felker</surname><given-names>I. G.</given-names></name></name-alternatives><email xlink:type="simple">felkeririna@sibmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филинюк</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Filinyuk</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">felkeririna@sibmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Янова</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yanova</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">felkeririna@sibmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щегерцов</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Schegertsov</surname><given-names>D. Yu.</given-names></name></name-alternatives><email xlink:type="simple">felkeririna@sibmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Сибирский государственный медицинский университет, ОГБУЗ «Томская областная клиническая туберкулезная больница», г. Томск</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Сибирский государственный медицинский университет, г. Томск</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Сибирский государственный медицинский университет,ОГБУЗ «Томская областная клиническая туберкулезная больница», г. Томск</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2012</year></pub-date><volume>11</volume><issue>4</issue><fpage>171</fpage><lpage>172</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фелькер И.Г., Филинюк О.В., Янова Г.В., Щегерцов Д.Ю., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Фелькер И.Г., Филинюк О.В., Янова Г.В., Щегерцов Д.Ю.</copyright-holder><copyright-holder xml:lang="en">Felker I.G., Filinyuk O.V., Yanova G.V., Schegertsov D.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/571">https://bulletin.ssmu.ru/jour/article/view/571</self-uri><abstract><p>С целью выявления предикторов неудачного исхода противотуберкулезной терапии у пациентов с множественной лекарственной устойчивостью M. tuberculosis проведен сравнительный анализ клинических, лабораторных, бактериологических и рентгенологических данных в условиях программы DOTS-PLUS. Полученные результаты показали, что предикторную роль играли как социальные, так и медико-биологические факторы, учитывая которые уже на начальном этапе возможно прогнозирование исходов лечения.</p></abstract><trans-abstract xml:lang="en"><p>For the purpose of revealing predictors failure outcome of antitubercular therapy at patients suffering from multidrug resistant tuberculosis we have executed comparative analysis of clinical, laboratory, bacteriological and radiological data in the conditions of DOTS-PLUS program. The received results have shown that predictors were social, medical and biologic factors, according which we can forecast treatment’s outcomes at initial stage.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулез легких</kwd><kwd>множественная лекарственная устойчивость</kwd><kwd>лечение</kwd><kwd>программа DOTS-PLUS</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tuberculosis of lungs</kwd><kwd>multidrug resistant</kwd><kwd>treatment</kwd><kwd>DOTS-PLUS program</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика, химиотерапия, хирургия лекарственно-устойчивого туберкулеза органов дыхания: практ. руководство / под ред. А.К. Стрелиса, А.А. Стрелиса. Томск: Красное знамя, 2007. 256 с.</mixed-citation><mixed-citation xml:lang="en">Диагностика, химиотерапия, хирургия лекарственно-устойчивого туберкулеза органов дыхания: практ. руководство / под ред. А.К. Стрелиса, А.А. Стрелиса. Томск: Красное знамя, 2007. 256 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Singla R., Sarin R., Khalid U.K. et al. Seven-year DOTS-PLUS pilot experience in India: results, constraints and issues // The Intern. J. of Tuberculosis and Lung Disease. 2009. № 13. P. 976—981.</mixed-citation><mixed-citation xml:lang="en">Singla R., Sarin R., Khalid U.K. et al. Seven-year DOTS-PLUS pilot experience in India: results, constraints and issues // The Intern. J. of Tuberculosis and Lung Disease. 2009. № 13. P. 976—981.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zager M.E., McNerney R. Multidrug-resistant tuberculosis // BMC Infect. Dis. 2008. V. 8. P. 10.</mixed-citation><mixed-citation xml:lang="en">Zager M.E., McNerney R. Multidrug-resistant tuberculosis // BMC Infect. Dis. 2008. V. 8. P. 10.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
