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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2024-3-163-171</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-5752</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Арахноидальная внутримозговая киста у мужчины 28 лет. Клинический случай с летальным исходом</article-title><trans-title-group xml:lang="en"><trans-title>Intracranial arachnoid cyst in a 28-year-old man. A clinical case with a fatal outcome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1909-1681</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крахмаль</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krakhmal</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крахмаль Надежда Валерьевна – канд. мед. наук, доцент, ст. науч. сотрудник, отделение общей и молекулярной патологии, НИИ онкологии, Томский НИМЦ; доцент кафедры патологической анатомии, СибГМУ</p><p>634050, г. Томск, Московский тракт, 2; 634009, г. Томск, пер. Кооперативный, 5</p></bio><bio xml:lang="en"><p>2, Moscow Trakt, Tomsk, 634050; 5, Kooperativny Str., Tomsk, 634009</p></bio><email xlink:type="simple">krakhmal@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3868-2310</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наумов Сергей Сергеевич – врач-патологоанатом, клиники СибГМУ; аспирант, ассистент кафедры патологической анатомии, СибГМУ</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>2, Moscow Trakt, Tomsk, 634050</p></bio><email xlink:type="simple">serg.nau2011@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-4085-3612</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вторушин</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vtorushin</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вторушин Константин Сергеевич – студент, кафедра патологической анатомии</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>2, Moscow Trakt, Tomsk, 634050</p></bio><email xlink:type="simple">konstantinvtorushin.doctor@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-0375-3314</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минеханов</surname><given-names>Т. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Minekhanov</surname><given-names>T. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минеханов Тимур Ришатович – студент, кафедра патологической анатомии</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>2, Moscow Trakt, Tomsk, 634050</p></bio><email xlink:type="simple">minexanov2013@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9429-9813</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Завьялова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zavyalova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Завьялова Марина Викторовна – д-р мед. наук, профессор, вед. науч. сотрудник, отделение общей и молекулярной патологии, НИИ онкологии, Томский НИМЦ; зав. кафедрой патологической анатомии, СибГМУ</p><p>634050, г. Томск, Московский тракт, 2; 634009, г. Томск, пер. Кооперативный, 5</p></bio><bio xml:lang="en"><p>2, Moscow Trakt, Tomsk, 634050; 5, Kooperativny Str., Tomsk, 634009</p></bio><email xlink:type="simple">zavyalovamv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1195-4008</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вторушин</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vtorushin</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вторушин Сергей Владимирович – д-р мед. наук, профессор, руководитель отделения общей и молекулярной патологии, НИИ онкологии, Томский НИМЦ; профессор кафедры патологической анатомии, СибГМУ</p><p>634050, г. Томск, Московский тракт, 2; 634009, г. Томск, пер. Кооперативный, 5</p></bio><bio xml:lang="en"><p>2, Moscow Trakt, Tomsk, 634050; 5, Kooperativny Str., Tomsk, 634009</p></bio><email xlink:type="simple">wtorushin@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет; &#13;
Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University; &#13;
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>11</day><month>10</month><year>2024</year></pub-date><volume>23</volume><issue>3</issue><fpage>163</fpage><lpage>171</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крахмаль Н.В., Наумов С.С., Вторушин К.С., Минеханов Т.Р., Завьялова М.В., Вторушин С.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Крахмаль Н.В., Наумов С.С., Вторушин К.С., Минеханов Т.Р., Завьялова М.В., Вторушин С.В.</copyright-holder><copyright-holder xml:lang="en">Krakhmal N.V., Naumov S.S., Vtorushin K.S., Minekhanov T.R., Zavyalova M.V., Vtorushin S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/5752">https://bulletin.ssmu.ru/jour/article/view/5752</self-uri><abstract><p>Арахноидальные внутримозговые кисты представляют собой чаще врожденные, отграниченные листками паутинной оболочки пространства (образования кистозного строения), заполненные спинномозговой жидкостью, распространенность их составляет до 1% от всех объемных образований данной локализации, процесс в большинстве случаев имеет доброкачественный характер течения. У детей частота выявления патологии составляет 2,6%, этот показатель у взрослых пациентов соответствует значению 1,4%, несколько чаще заболевание регистрируется среди мужчин. Наиболее часто подобные кисты имеют супратенториальное расположение, преимущественно они диагностируются в средней черепной ямке, в ретроцеребеллярной области, реже их можно обнаружить в конвекситальных отделах больших полушарий, также описаны случаи более редких особых локализаций, в том числе у новорожденных. Патология часто характеризуется бессимптомным течением, при этом возникновение определенной симптоматики может иметь острое начало, обусловлено крупными размерами кист со сдавлением структур головного мозга.</p><p>В статье представлено описание случая внутримозговой арахноидальной кисты больших размеров у мужчины 28 лет, не верифицированной прижизненно и выявленной лишь посмертно на основании данных патологоанатомического исследования (макроскопические особенности образования, гистологическая картина с характерными морфологическими изменениями и данные компьютерной томографии больших полушарий головного мозга).</p></abstract><trans-abstract xml:lang="en"><p>Most intracranial arachnoid cysts are thought to be non-tumorous, congenital, intra-arachnoid cerebrospinal fluid collections that account for about 1% of all intracranial space-occupying lesions. In children, the prevalence of this pathology is 2.6%; in adults, it reaches 1.4%. The disease is more often registered in men. Most often arachnoid cysts are supratentorial. Their most common locations are in the middle cranial fossa and the retrocerebellar cistern. Less often they can be detected on the convexity of the brain hemispheres; however, cases of arachnoid cysts at more unusual sites have also been described, including in newborns. The pathology is often characterized by an asymptomatic course, while certain symptoms may have an acute onset, which is due to compression of brain structures caused by the large cyst size.</p><p>This article describes a clinical case of a large intracranial arachnoid cyst in a 28-year-old man. It was not verified in the antemortem diagnosis, but was revealed according to the autopsy findings (macroscopic features of the cyst, histologic presentation with specific morphological changes, and findings of computed tomography of the cerebral hemispheres).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>арахноидальная внутримозговая киста</kwd><kwd>морфология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>intracranial arachnoid cyst</kwd><kwd>morphology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Jafrani R., Raskin J.S., Kaufman A., Lam S. Intracranial arachnoid cysts: pediatric neurosurgery update. Surg. Neurol. Int. 2019;10:15. DOI: 10.4103/sni.sni_320_18.</mixed-citation><mixed-citation xml:lang="en">Jafrani R., Raskin J.S., Kaufman A., Lam S. Intracranial arachnoid cysts: pediatric neurosurgery update. Surg. Neurol. Int. 2019;10:15. DOI: 10.4103/sni.sni_320_18.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Yildiz H., Erdogan C., Yalcin R., Yazici Z., Hakyemez B., Parlak M., Tuncel E. Evaluation of communication between intracranial arachnoid cysts and cisterns with phase-contrast cine MR imaging. AJNR Am. J. Neuroradiol. 2005;26(1):145–151.</mixed-citation><mixed-citation xml:lang="en">Yildiz H., Erdogan C., Yalcin R., Yazici Z., Hakyemez B., Parlak M., Tuncel E. Evaluation of communication between intracranial arachnoid cysts and cisterns with phase-contrast cine MR imaging. AJNR Am. J. Neuroradiol. 2005;26(1):145–151.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mustansir F., Bashir S., Darbar A. Management of Arachnoid Cysts: A Comprehensive Review. Cureus. 2018;10(4):e2458. DOI: 10.7759/cureus.2458.</mixed-citation><mixed-citation xml:lang="en">Mustansir F., Bashir S., Darbar A. Management of Arachnoid Cysts: A Comprehensive Review. Cureus. 2018;10(4):e2458. DOI: 10.7759/cureus.2458.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Canty K.W., Shiroishi M.S., Zada G., Sharma S., Jimenez M.A. Bilateral arachnoid cyst-associated subdural fluid collections in an infant following TBI. J. Forensic Leg. Med. 2021;81:102189. DOI: 10.1016/j.jflm.2021.102189.</mixed-citation><mixed-citation xml:lang="en">Canty K.W., Shiroishi M.S., Zada G., Sharma S., Jimenez M.A. Bilateral arachnoid cyst-associated subdural fluid collections in an infant following TBI. J. Forensic Leg. Med. 2021;81:102189. DOI: 10.1016/j.jflm.2021.102189.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Holou W.N., Terman S., Kilburg C., Garton H.J., Muraszko K.M., Maher C.O. Prevalence and natural history of arachnoid cysts in adults. J. Neurosurg. 2013;118(2):222–231. DOI: 10.3171/2012.10.JNS12548.</mixed-citation><mixed-citation xml:lang="en">Al-Holou W.N., Terman S., Kilburg C., Garton H.J., Muraszko K.M., Maher C.O. Prevalence and natural history of arachnoid cysts in adults. J. Neurosurg. 2013;118(2):222–231. DOI: 10.3171/2012.10.JNS12548.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Qin X., Wang Y., Xu S., Hong X. Familial arachnoid cysts: a review of 35 families. Childs Nerv. Syst. 2019;35(4):607–612. DOI: 10.1007/s00381-019-04060-z.</mixed-citation><mixed-citation xml:lang="en">Qin X., Wang Y., Xu S., Hong X. Familial arachnoid cysts: a review of 35 families. Childs Nerv. Syst. 2019;35(4):607–612. DOI: 10.1007/s00381-019-04060-z.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Di Perna G., Piatelli G., Rossi A., Consales A., Fiaschi P., Castaldo M. et al. Retrocerebellar Arachnoid Cyst and Chiari Type 1 Malformation: 3 Pediatric Cases of Surgical Management Tailored to the Pathogenic Mechanism and Systematic Review of the Literature. World Neurosurg. 2021;148:44–53. DOI: 10.1016/j.wneu.2020.12.094.</mixed-citation><mixed-citation xml:lang="en">Di Perna G., Piatelli G., Rossi A., Consales A., Fiaschi P., Castaldo M. et al. Retrocerebellar Arachnoid Cyst and Chiari Type 1 Malformation: 3 Pediatric Cases of Surgical Management Tailored to the Pathogenic Mechanism and Systematic Review of the Literature. World Neurosurg. 2021;148:44–53. DOI: 10.1016/j.wneu.2020.12.094.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Fewel M.E., Levy M.L., McComb J.G. Surgical treatment of 95 children with 102 intracranial arachnoid cysts. Pediatr. Neurosurg. 1996;25(4):165–173. DOI: 10.1159/000121119.</mixed-citation><mixed-citation xml:lang="en">Fewel M.E., Levy M.L., McComb J.G. Surgical treatment of 95 children with 102 intracranial arachnoid cysts. Pediatr. Neurosurg. 1996;25(4):165–173. DOI: 10.1159/000121119.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Holou W.N., Yew A.Y., Boomsaad Z.E., Garton H.J., Muraszko K.M., Maher C.O. Prevalence and natural history of arachnoid cysts in children. J. Neurosurg. Pediatr. 2010;5(6):578–585. DOI: 10.3171/2010.2.PEDS09464.</mixed-citation><mixed-citation xml:lang="en">Al-Holou W.N., Yew A.Y., Boomsaad Z.E., Garton H.J., Muraszko K.M., Maher C.O. Prevalence and natural history of arachnoid cysts in children. J. Neurosurg. Pediatr. 2010;5(6):578–585. DOI: 10.3171/2010.2.PEDS09464.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Akutagawa K., Tamura G., Tsurubuchi T., Ishikawa E., Matsumura A., Inagaki T. Quadrigeminal arachnoid cyst with perinatal encephalocele. Childs Nerv. Syst. 2020;36(7):1393– 1397. DOI: 10.1007/s00381-020-04626-2.</mixed-citation><mixed-citation xml:lang="en">Akutagawa K., Tamura G., Tsurubuchi T., Ishikawa E., Matsumura A., Inagaki T. Quadrigeminal arachnoid cyst with perinatal encephalocele. Childs Nerv. Syst. 2020;36(7):1393– 1397. DOI: 10.1007/s00381-020-04626-2.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Albakr A., Sader N., Lama S., Sutherland G.R. Interhemispheric arachnoid cyst. Surg. Neurol. Int. 2021;12:125. DOI: 10.25259/SNI_660_2020.</mixed-citation><mixed-citation xml:lang="en">Albakr A., Sader N., Lama S., Sutherland G.R. Interhemispheric arachnoid cyst. Surg. Neurol. Int. 2021;12:125. DOI: 10.25259/SNI_660_2020.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Endo M., Usami K., Masaaki N., Ogiwara H. A neonatal purely prepontine arachnoid cyst: a case report and review of the literature. Childs Nerv. Syst. 2022;38(9):1813–1816. DOI: 10.1007/s00381-022-05457-z.</mixed-citation><mixed-citation xml:lang="en">Endo M., Usami K., Masaaki N., Ogiwara H. A neonatal purely prepontine arachnoid cyst: a case report and review of the literature. Childs Nerv. Syst. 2022;38(9):1813–1816. DOI: 10.1007/s00381-022-05457-z.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ichinose T., Miyashita K., Tanaka S., Oikawa N., Oishi M., Nambu I. et al. Recurrent Spinal Intramedullary Arachnoid Cyst: Case Report and Literature Review. World Neurosurg. 2020;138:68–72. DOI: 10.1016/j.wneu.2020.02.106.</mixed-citation><mixed-citation xml:lang="en">Ichinose T., Miyashita K., Tanaka S., Oikawa N., Oishi M., Nambu I. et al. Recurrent Spinal Intramedullary Arachnoid Cyst: Case Report and Literature Review. World Neurosurg. 2020;138:68–72. DOI: 10.1016/j.wneu.2020.02.106.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">De Longpre J. Large Arachnoid Cyst. N. Engl. J. Med. 2017;376(23):2265. DOI: 10.1056/NEJMicm1610483.</mixed-citation><mixed-citation xml:lang="en">De Longpre J. Large Arachnoid Cyst. N. Engl. J. Med. 2017;376(23):2265. DOI: 10.1056/NEJMicm1610483.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fadul K.Y., Ali M., Abdelrahman A., I Ahmed S.M., Fadul A., Ali H., Elgassim M. Arachnoid cyst: a sudden deterioration. Cureus. 2023;15(3):e36552. DOI: 10.7759/cureus.36552.</mixed-citation><mixed-citation xml:lang="en">Fadul K.Y., Ali M., Abdelrahman A., I Ahmed S.M., Fadul A., Ali H., Elgassim M. Arachnoid cyst: a sudden deterioration. Cureus. 2023;15(3):e36552. DOI: 10.7759/cureus.36552.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rabiei K., Tisell M., Wikkelsø C., Johansson B.R. Diverse arachnoid cyst morphology indicates different pathophysiological origins. Fluids Barriers CNS. 2014;11(1):5. DOI: 10.1186/2045-8118-11-5.</mixed-citation><mixed-citation xml:lang="en">Rabiei K., Tisell M., Wikkelsø C., Johansson B.R. Diverse arachnoid cyst morphology indicates different pathophysiological origins. Fluids Barriers CNS. 2014;11(1):5. DOI: 10.1186/2045-8118-11-5.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
