ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2024-4-169-176ssmu-5884Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESАнгиогенин: биологическая роль, механизмы действия и участие в онкогенезеAngiogenin: biological role, mechanisms of action, and participation in oncogenesishttps://orcid.org/0000-0002-0647-3576МихалевД. Е.MikhalevD. E.

Михалев Дмитрий Евгеньевич – ассистент, кафедра стоматологии, 

634050, г. Томск, Московский тракт, 2

2, Moskow Trakt, Tomsk, 634050

dm199412@gmail.comhttps://orcid.org/0009-0008-7371-318XКоротенкоС. Н.KorotenkoS. N.

Коротенко Сергей Николаевич – аспирант, кафедра стоматологии,

634050, г. Томск, Московский тракт, 2

2, Moskow Trakt, Tomsk, 634050

dr.korotenko@mail.ruhttps://orcid.org/0009-0001-7162-1475ЛомовскихА. Ю.LomovskikhA. Yu.

Ломовских Анастасия Юрьевна – студент, лечебный факультет, 

634050, г. Томск, Московский тракт, 2

2, Moskow Trakt, Tomsk, 634050

anastasia17070316@mail.ruhttps://orcid.org/0000-0002-4748-4175БайдикО. Д.BaydikO. D.

Байдик Ольга Дмитриевна – д-р мед. наук, профессор, зав. кафедрой стоматологии,

634050, г. Томск, Московский тракт, 2

2, Moskow Trakt, Tomsk, 634050

olgabajdik@yandex.ruСибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical UniversityRussian Federation202427012025234169176Copyright © Михалев Д.Е., Коротенко С.Н., Ломовских А.Ю., Байдик О.Д., 20252025Михалев Д.Е., Коротенко С.Н., Ломовских А.Ю., Байдик О.Д.Mikhalev D.E., Korotenko S.N., Lomovskikh A.Y., Baydik O.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/5884

Ангиогенин – небольшой полипептид, состоящий из 123 аминокислот, вовлеченный в процессы ангиогенеза и онкогенеза. Данный белок играет важную роль в различных физиологических и патологических процессах посредством регуляции пролиферации, выживания, миграции, инвазии и дифференцировки клеток.

В лекции представлены данные о получении, взаимодействии ангиогенина с различными белками, приведены механизмы действия, показана биологическая роль в ангиогенезе и онкогенезе. Поиск литературы осуществлялся в поисковых системах PubMed, Medline, Elibrary, Scopus, The Cochrane Library, РИНЦ.

Angiogenin is a small polypeptide consisting of 123 amino acids involved in the processes of angiogenesis and tumorigenesis. This protein plays an important role in various physiological and pathological processes through the regulation of cell proliferation, survival, migration, invasion, and differentiation.

The lecture presents data on angiogenin production and interaction with various proteins, describes mechanisms of its action, and shows its biological role in angiogenesis and oncogenesis. The literature search was carried out in the PubMed, Medline, Elibrary, Scopus, The Cochrane Library, and RSCI search engines.

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The authors declare that there are no conflicts of interest present.