ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2024-4-187-196ssmu-5886Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРоль медиаторов в формировании ведущих патологических процессов при псориатическом артритеThe role of mediators in the formation of leading pathological processes in psoriatic arthritishttps://orcid.org/0000-0002-5903-3662ПогонченковаД. А.PogonchenkovaD. A.

Погонченкова Дарья Александровна – канд. мед. наук, зав. ревматологическим отделением, МЦ «Профессор», 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

pogonchenkova.da@ssmu.ruhttps://orcid.org/0009-0003-0436-5349ЧетверняЛ. В.ChetvernyaL. V.

Четверня Лада Вячеславовна – врач-ревматолог, МЦ «Профессор», 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

chetvernya.lv@ssmu.ruhttps://orcid.org/0000-0002-2882-4533ВасильеваО. А.VasilyevaO. A.

Васильева Ольга Александровна – канд. мед. наук, доцент кафедры патофизиологии, доцент кафедры биохимии и молекулярной биологии с курсом клинической лабораторной диагностики, 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

vasileva.oa@ssmu.ruhttps://orcid.org/0000-0001-8457-9440КононоваТ. Е.KononovaT. E.

Кононова Татьяна Евгеньевна – канд. мед. наук, доцент, доцент кафедры патофизиологии, 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

kononova.te@ssmu.ruhttps://orcid.org/0000-0002-2005-305XПолетикаВ. С.PoletikaV. S.

Полетика Вадим Сергеевич – канд. мед. наук, доцент кафедры патофизиологии, 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

vpoletika@yandex.ruhttps://orcid.org/0000-0002-7991-9786АбрамовВ. К.AbramovV. K.

Абрамов Виталий Константинович – лаборант-исследователь, кафедра патофизиологии,

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

abramoff.vk@yandex.ruhttps://orcid.org/0000-0003-3468-6154ЧумаковаС. П.ChumakovaS. P.

Чумакова Светлана Петровна – д-р мед. наук, доцент, профессор кафедры патофизиологии, 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

chumakova.sp@ssmu.ruhttps://orcid.org/0000-0001-9089-3321ЕлисееваЛ. В.EliseevaL. V.

Елисеева Лариса Васильевна – канд. мед. наук, зав. ревматологическим отделением, ассистент кафедры факультетской терапии с курсом клинической фармакологии, 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

eliseeva.lv@ssmu.ruhttps://orcid.org/0000-0002-9457-8879УразоваО. И.UrazovaO. I.

Уразова Ольга Ивановна – д-р мед. наук, профессор, член-корр. РАН, зав. кафедрой патофизиологии, 

634050, г. Томск, Московский тракт, 2

2, Moscow Trakt, Tomsk, 634050

urazova.oi@ssmu.ruСибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical UniversityRussian Federation202427012025234187196Copyright © Погонченкова Д.А., Четверня Л.В., Васильева О.А., Кононова Т.Е., Полетика В.С., Абрамов В.К., Чумакова С.П., Елисеева Л.В., Уразова О.И., 20252025Погонченкова Д.А., Четверня Л.В., Васильева О.А., Кононова Т.Е., Полетика В.С., Абрамов В.К., Чумакова С.П., Елисеева Л.В., Уразова О.И.Pogonchenkova D.A., Chetvernya L.V., Vasilyeva O.A., Kononova T.E., Poletika V.S., Abramov V.K., Chumakova S.P., Eliseeva L.V., Urazova O.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/5886

В лекции проанализированы результаты исследований, касающихся роли гуморальных и клеточных медиаторов, их взаимодействия, а также дисбаланса ангиогенных факторов при псориатическом артрите. Информация структурирована в соответствии с выделением ведущих типовых патологических процессов: воспаления и нарушений микроциркуляции, формирующихся за счет активации белковых каскадов и взаимодействия молекулярных провоспалительных медиаторов и ангиогенных факторов. Известно, что клинические фенотипы псориатического артрита многообразны. Глубокое понимание патогенеза и динамики изменений в преобладании одного патологического процесса над другим может стать основой для разработки персонифицированного патогенетически обоснованного терапевтического подхода с минимизацией ятрогенных осложнений и экономических издержек, а также внедрения современных диагностических методов для верификации, дифференциации и мониторинга активности псориатического артрита с целью своевременной коррекции медикаментозной стратегии.

The lecture analyzes the results of research on the role of humoral and cellular mediators, their interaction, as well as the imbalance of angiogenic factors in psoriatic arthritis. The information is presented with identification of the leading typical pathological processes: inflammation and microcirculation disorders, formed due to the activation of protein cascades and interaction of molecular proinflammatory mediators and angiogenic factors. It is known that the clinical phenotypes of psoriatic arthritis are diverse. A deeper understanding of the pathogenesis and changes in the predominant pathological process can become the basis for the development of a personalized treatment strategy based on the pathogenesis to minimize iatrogenic complications and economic costs, as well as for the introduction of modern diagnostic methods for verification, differentiation, and monitoring of psoriatic arthritis in order to timely correct drug treatment.

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The authors declare that there are no conflicts of interest present.