ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2025-3-89-96ssmu-6167Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSОценка ранозаживляющего действия субстанций на основе ланолина и экстрактов ксилотрофных базидиомицетов Ganoderma applanatum и Fomitopsis pinicolaWound-healing effect of substances based on lanolin and Ganoderma applanatum and Fomitopsis pinicola (xylotrophic basidiomycetes) extractshttps://orcid.org/0000-0002-4358-5219ПетроваИ. М.PetrovaI. M.

Петрова Ирина Михайловна – старший преподаватель, департамент биологии и фундаментальной медицины, Институт естественных наук и математики (ИЕНиМ) УрФУ.

620002, Екатеринбург, ул. Мира, 19

19 Mira St., 620002 Yekaterinburg

Irina.Petrova@urfu.ruhttps://orcid.org/0000-0003-2784-4898ЕрмошинА. А.ErmoshinA. A.

Ермошин Александр Анатольевич – канд. биол. наук, доцент, кафедра экспериментальной биологии и биотехнологий, ИЕНиМ УрФУ.

620002, Екатеринбург, ул. Мира, 19

19 Mira St., 620002 Yekaterinburg

Alexander.Ermoshin@urfu.ruhttps://orcid.org/0000-0001-5921-6680ХацкоС. Л.KhatskoS. L.

Хацко Сергей Леонидович – зав. анатомо-физиологической экспериментальной лабораторией, ИЕНиМ УрФУ.

620002, Екатеринбург, ул. Мира, 19

19 Mira St., 620002 Yekaterinburg

sergey.khatsko@urfu.ruУральский федеральный университет (УрФУ) им. первого Президента России Б.Н. ЕльцинаРоссияUral Federal University named after the first President of Russia B.N. YeltsinRussian Federation2025151020252438996Copyright © Петрова И.М., Ермошин А.А., Хацко С.Л., 20252025Петрова И.М., Ермошин А.А., Хацко С.Л.Petrova I.M., Ermoshin A.A., Khatsko S.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/6167Цель

Цель: оценить ранозаживляющее действие субстанций на основе ланолина и экстрактов ксилотрофных базидиомицетов Ganoderma applanatum и Fomitopsis pinicola.

Материалы и методы

Материалы и методы. Эксперимент проводили на 20 белых лабораторных крысах. Животным моделировали термический ожог III степени с последующим воздействием на раны мазью, содержащей экстракты трутовых грибов. Проводили морфологическое описание препаратов кожи с оценкой следующих показателей: толщина эпидермиса, количество фибробластов, количество кровеносных сосудов, площадь сосудов, количество сосудов с явлениями эритростаза, лейкостаза и лейкодиапедеза.

Результаты

Результаты. При воздействии экстрактов трутовых грибов отмечается интенсификация регенераторных процессов. К 14-м сут эксперимента имела место полная эпителизация, а на месте дефекта формировался рубец с развитым волокнистым компонентом. Использование мазей способствует уменьшению экссудативных явлений, микроциркуляторных расстройств и воспалительной инфильтрации.

Заключение

Заключение. Показано, что использование экстрактов Ganoderma applanatum и Fomitopsis pinicola при лечении ожоговой раны благоприятно сказывается на течении раневого процесса. Полученные результаты позволяют осуществлять дальнейшее изучение экстрактов трутовых грибов в качестве ранозаживляющих агентов.

Aim

Aim. To evaluate the wound-healing effect of substances based on lanolin and Ganoderma applanatum and Fomitopsis pinicola extracts.

Materials and Methods

Materials and Methods. The experiment used 20 white laboratory rats. The study included 3rd-degree burn modeling with wound exposure to an ointment containing Ganoderma applanatum and Fomitopsis pinicola extracts. A morphological investigation of skin was carried out with an assessment of the following parameters: epidermis thickness, fibroblast count, number of blood vessels, vessel area, and number of vessels with erythrocyte stasis, leukocyte stasis, and leukocyte diapedesis.

Results

Results. Ganoderma applanatum and Fomitopsis pinicola extracts intensified regenerative processes. By day 14 of the experiment, epithelialization of the defect and scar formation took place. Application of the extract-containing ointments reduced exudation, microcirculatory disorders, and inflammatory infiltration.

Conclusion

Conclusion. The results suggested the beneficial effect of the Ganoderma applanatum and Fomitopsis pinicola extracts on the wound-healing process and demonstrated their potential for skin regeneration.

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The authors declare that there are no conflicts of interest present.