ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2025-3-163-171ssmu-6174Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРоль витамина D в иммуноадъювантной терапии туберкулеза в зависимости от ВИЧ-статуса пациентовThe role of vitamin D in immunoadjuvant therapy for tuberculosis depending on the HIV status of patientshttps://orcid.org/0000-0002-5526-2513ФилинюкО. В.FilinyukO. V.

Филинюк Ольга Владимировна – д-р мед. наук, профессор, зав. кафедрой фтизиатрии и пульмонологии, СибГМУ.

634050, Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

filinyuk.olga@yandex.ruhttps://orcid.org/0009-0005-3385-0575ХохлюкВ. В.KhokhlyukV. V.

Хохлюк Василина Вячеславовна – студентка, СибГМУ.

634050, Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

khokhliuk2001@mail.ruhttps://orcid.org/0009-0001-1233-5874ВолковскаяА. О.VolkovskayaA. O.

Волковская Анастасия Олеговна – студентка, СибГМУ.

634050, Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

nastya120701@yandex.ruСибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical UniversityRussian Federation202515102025243163171Copyright © Филинюк О.В., Хохлюк В.В., Волковская А.О., 20252025Филинюк О.В., Хохлюк В.В., Волковская А.О.Filinyuk O.V., Khokhlyuk V.V., Volkovskaya A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/6174

В базах данных PubMed и eLIBRARY.RU по ключевым словам были проведены поисковые запросы, включающие публикации за 2018–2024 гг. Представлен анализ литературы о дефиците витамина D у больных при туберкулезе (ТБ), вирусе иммунодефицита человека (ВИЧ), в сочетании ТБ и ВИЧ, который выявил неоднородную распространенность. Показана роль витамина D в иммунологическом ответе организма при ТБ в зависимости от наличия ВИЧ-инфекции. Приведены данные терапевтического применения в качестве адьюванта к химиотерапии туберкулеза витамина D в различных дозировках в однократном и пролонгированном введении. Обозначены перспективы использования витамина D в комбинированном лечении больных ТБ в зависимости от ВИЧ-статуса, особенно со множественной лекарственной устойчивостью возбудителя, требующие изучения в российских клинических исследованиях.

Search queries were conducted in the PubMed and eLIBRARY.ru databases using keywords, including publications from 2018–2024. A review of the literature on vitamin D deficiency in patients with tuberculosis (TB), human immunodeficiency virus (HIV), and TB/HIV combination is presented, which revealed heterogeneous prevalence. The roles of vitamin D in the body immune response to TB are shown depending on the presence of HIV infection. The data on the therapeutic use of single and prolonged administration of vitamin D at various doses in adjuvant TB therapy are presented. The prospects for the use of vitamin D in the combined treatment of TB patients are outlined depending on the HIV status, especially with multidrug-resistant pathogens requiring study in Russian clinical trials.

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The authors declare that there are no conflicts of interest present.