ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2025-4-153-163ssmu-6273Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESНейротрофический фактор мозга: значение в физиологии и патологии сердечно-сосудистой системыBrain-derived neurotrophic factor: significance in the physiology and pathology of the cardiovascular systemhttps://orcid.org/0000-0003-3274-6010ЛасуковаТ. В.LasukovaT. V.

Ласукова Татьяна Викторовна – д-р биол. наук, профессор, профессор кафедры нормальной физиологии

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

tlasukova@mail.ruhttps://orcid.org/0000-0002-7269-5468ЗагуловаД. В.ZagulovaD. V.

Загулова Диана В. – д-р мед. наук, зав. лабораторией экспериментальной физиологии, профессор кафедры нормальной физиологии

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

zagulova.d@ssmu.ruhttps://orcid.org/0000-0001-7156-2471КолобовниковаЮ. В.KolobovnikovaYu. V.

Колобовникова Юлия Владимировна – д-р мед. наук, доцент, зав. кафедрой нормальной физиологии, декан медико-биологического факультета

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

kolobovnikova.julia@mail.ruhttps://orcid.org/0000-0002-0119-9707НосаревА. В.NosarevА. V.

Носарев Алексей Валерьевич – д-р мед. наук, доцент, профессор кафедры биофизики и функциональной диагностики, профессор кафедры нормальной физиологии

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

avnosarev@yandex.ruhttps://orcid.org/0009-0007-8323-5401МартюшеваЭ. В.MartyushevaE. V.

Мартюшева Эрна Владимировна – аспирант, кафедра нормальной физиологии

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

totumacheva.erna@yandex.ruhttps://orcid.org/0000-0001-9034-4226ПетроваИ. В.PetrovaI. V.

Петрова Ирина Викторовна – д-р биол. наук, профессор, профессор кафедры биофизики и функциональной диагностики

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

ivpetrova57@yandex.ruhttps://orcid.org/0000-0001-9339-6304СтеповаяЕ. А.StepovayaE. A.

Степовая Елена Алексеевна – д-р мед. наук, профессор кафедры биохимии и молекулярной биологии с курсом клинической лабораторной диагностики

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

stepovaya.ea@ssmu.ruhttps://orcid.org/0000-0003-0680-8249АкбашеваО. Е.AkbashevaO. E.

Акбашева Ольга Евгеньевна – д-р мед. наук, профессор кафедра биохимии и молекулярной биологии с курсом клинической лабораторной диагностики

634050, г. Томск, Московский тракт, 2

2 Moskovsky trakt, 634050 Tomsk

akbasheva.oe@ssmu.ruСибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical UniversityRussian Federation202512012026244153163Copyright © Ласукова Т.В., Загулова Д.В., Колобовникова Ю.В., Носарев А.В., Мартюшева Э.В., Петрова И.В., Степовая Е.А., Акбашева О.Е., 20252025Ласукова Т.В., Загулова Д.В., Колобовникова Ю.В., Носарев А.В., Мартюшева Э.В., Петрова И.В., Степовая Е.А., Акбашева О.Е.Lasukova T.V., Zagulova D.V., Kolobovnikova Y.V., Nosarev А.V., Martyusheva E.V., Petrova I.V., Stepovaya E.A., Akbasheva O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/6273

В лекции проведен анализ литературных данных о роли нейротрофического фактора мозга (BDNF) в развитии и функционировании сердечно-сосудистой системы и его участии в патогенезе сердца и сосудов. Информация структурирована в соответствии с многофункциональными свойствами и эффектами BDNF, позволяющими рассматривать нейротрофический фактор мозга в качестве терапевтической мишени для ослабления миокардиальной дисфункции и восстановления деятельности сердца при ишемии/реперфузии.

Приведены данные о способности нейрокина оказывать кардиопротекторное действие посредством активации ангиогенеза и неоваскуляризации ишемизированной ткани миокарда путем повышения жизнеспособности эндотелиоцитов. Известно, что вегетативный тонус является важнейшим показателем состояния сердечно-сосудистой системы. Вопрос о характере влияния нейротрофического фактора мозга на активность симпатических и парасимпатических нейронов остается открытым. Однако в настоящее время преобладает мнение о том, что BDNF регулирует частоту сердечных сокращений, усиливая парасимпатическую активность стволовых структур головного мозга. На основании экспериментальных и клинических сведений рассматриваются перспективы применения аналогов нейрокина в кардиологической практике.

The lecture provides an analysis of literature data on the role of brain-derived neurotrophic factor (BDNF) in the development and functioning of the cardiovascular system and its involvement in the heart and blood vessels pathogenesis. The information is structured according to the multifunctional properties and effects of BDNF allowing the brain-derived neurotrophic factor to be considered as a therapeutic target for attenuating myocardial dysfunction and restoring cardiac function during ischemia/reperfusion.

The lecture contains data on the ability of neurokine to exert a cardioprotective effect by activating angiogenesis and neovascularization of ischemic myocardial tissue via increasing endotheliocyte viability. It is known that vegetative tone is the most important indicator of the state of the cardiovascular system. The nature of brain-derived neurotrophic factor affecting the activity of sympathetic and parasympathetic neurons is yet to be determined. However, the current prevailing view is that BDNF regulates heart rate by enhancing parasympathetic activity of the brainstem structures. Based on experimental and clinical data, the prospects for the use of neurokine analogues in cardiology practice are considered.

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The authors declare that there are no conflicts of interest present.