ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2016-4-111-119ssmu-672Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESФакторы ангиогенеза при развитии физиологических и патологических процессов женской гонадыFactors of angiogenesis in the development of physiological and pathological processes of the female gonadsЗенкинаВ. Г.ZenkinaV. G.

канд. мед. наук, доцент, зав. кафедрой биологии, ботаники и экологии Тихоокеанского государственного медицинского университета, г. Владивосток

PhD, Associate Professor, Head of the Department of Biology, Botany and Ecology, Pacific State Medical University, Vladivostok, Russian Federation

zena-74@mail.ruТихоокеанский государственный медицинский университет 690950, г. Владивосток, пр-т Острякова, 2РоссияPacific State Medical University 2, Av. Ostruakova,Vladivostok, 690950, Russian FederationRussian Federation201604102016154111119Copyright © Зенкина В.Г., 20162016Зенкина В.Г.Zenkina V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/672

Обзор литературы посвящен роли различных факторов роста в развитии сосудистого русла яичников. В каждом овариально-менструальном цикле гонады претерпевают изменения, сопровождающиеся образованием и разрушением кровеносных сосудов. Васкуляризация играет важную роль как при физиологических процессах, таких как развитие и атрезия фолликула, образование желтого тела, так и при патологических (синдром гиперстимуляции яичников, образование фолликулярных кист, развитие поликистоза яичников, эндометриоза, дисфункциональных маточных кровотечений). Основным ангиогенным фактором определен сосудистый эндотелиальный фактор роста, участвующий самостоятельно и через опосредующие факторы в овариогенезе, играющий важную роль в эндотелиальной клеточной дифференцировке и развитии сосудистого рисунка, стимулирующий эндотелиальную пролиферацию, миграцию и выживание экстравазальных клеток яичника. Ангиогенная активность в яичниках находится также под контролем других ростовых факторов: фактора роста фибробластов, эпидермального фактора роста, фактора роста тромбоцитов, инсулино-подобного фактора роста-1, а также цитокинов (таких как тумор-некротический фактор, интерлейкины, компоненты экстрацеллюлярного матрикса (ламинин, фибронектин) и их рецепторы (интегрины), матричные металлопро регуляторы, протеазы (плазминоген, активаторы урокиназы и урокиназы тканевого типа)). Аберрантная продукция этих ангиогенных факторов может быть причиной сосудистой дисфункции и развития овариальных расстройств. Представлены различные точки зрения на проблему васкулогенеза в женской гонаде, а также направления для дальнейших фундаментальных и практических исследований.

The literature review focuses on the role of various growth factors in the developing vasculature of the ovary. Vascularization plays an important role in physiological processes such as development and atresia of a follicle, the formation of the yellow body and the pathological: ovarian hyperstimulation syndrome, the formation of follicular cysts, the development of cystic ovaries, endometriosis, dysfunctional uterine bleeding. The main angiogenic factor identified vascular endothelial growth factor, participates independently and through the mediating factors in baryogenesis, which plays an important role in endothelial cell differentiation and development of vascular pattern, stimulating endothelial proliferation, migration and survival of extravascular cells of the ovary. Angiogenic activity in the ovary is also under the control of other growth factors: fibroblast growth factor, epidermal growth factor, platelet growth factor, insulin-like growth factor-1 and cytokines such as tumor necrotic factor, interleukins, components of the extracellular matrix (laminin, fibronectin) and their receptors (integrins), matrix metalloproteinases and their tissue inhibitors and regulators, proteases (plasminogen, activators urokinase and urokinase tissue type), as well as hypoxia, hypoglycemia and stress. Presents different points of view on the problem of vasculogenesis in the female gonad, as well as directions for future fundamental and practical research.

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The authors declare that there are no conflicts of interest present.