ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2012-6-47-50ssmu-850Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ И КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯEXPERIMENTAL AND CLINICAL INVESTIGATIONSАссоциация полиморфизма Thr12Ser гена митохондриального фактора транскрипции А TFAM с ишемической болезнью сердцаAssociation of Thr12Ser polymorphism in mitochondrial transcription factor A TFAM gene with coronary artery diseaseЖейковаТ. В.ZheikovaT. V.zheykova@mail.ruГолубенкоМ. В.GolubenkoM. V.zheykova@mail.ruБуйкинС. В.BuikinS. V.zheykova@mail.ruМакееваО. А.MakeevaO. A.zheykova@mail.ruЛежневА. А.LezhnevA. A.zheykova@mail.ruЦимбалюкИ. В.TsimbalyukI. V.zheykova@mail.ruШипулинВ. М.ShipulinV. M.zheykova@mail.ruПузырёвВ. П.PuzyryovV. P.zheykova@mail.ruНИИ медицинской генетики СО РАМН, г. ТомскRussian FederationНИИ кардиологии СО РАМН, г. ТомскRussian FederationСибирский государственный медицинский университет, г. ТомскRussian Federation2012281220121164750Copyright © Жейкова Т.В., Голубенко М.В., Буйкин С.В., Макеева О.А., Лежнев А.А., Цимбалюк И.В., Шипулин В.М., Пузырёв В.П., 20122012Жейкова Т.В., Голубенко М.В., Буйкин С.В., Макеева О.А., Лежнев А.А., Цимбалюк И.В., Шипулин В.М., Пузырёв В.П.Zheikova T.V., Golubenko M.V., Buikin S.V., Makeeva O.A., Lezhnev A.A., Tsimbalyuk I.V., Shipulin V.M., Puzyryov V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/850

Проанализировано распределение генотипов и аллелей полиморфного варианта Thr12Ser (rs1937) гена TFAM в выборке лиц, больных ишемической болезнью сердца, и в популяционной выборке жителей г. Томска. Для проведения генотипирования использовали полиморфизм длин рестрикционных фрагментов. Выявлена статистически значимо более высокая частота генотипа СС у мужчин, больных ишемической болезнью сердца, — 4,52% по сравнению с популяционной выборкой мужчин — 0,45% (χ2 = 6,315; р = 0,043; OR = 10,45). Таким образом, генотип СС ассоциирован с ишемической болезнью сердца у мужчин в популяции г. Томска.

In this study we genotyped polymorphism Thr12Ser (rs1937) in TFAM gene in two groups: patients with coronary artery disease and control group (people from Tomsk population). For genotyping was used restriction fragment length polymorphism. We have found significant higher genotype CC frequency in men with coronary artery disease — 4.52% compared with control men — 0.45% (χ2 = 6.315; р = 0.043; OR = 10.45). Thus genotype CC is associated with coronary artery disease in men fromTomsk population.

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The authors declare that there are no conflicts of interest present.