ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2013-1-43-48ssmu-9Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ И КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯEXPERIMENTAL AND CLINICAL INVESTIGATIONSГИПОЛИПИДЕМИЧЕСКОЕ ДЕЙСТВИЕ ЛЕУКОМИЗИНА НА МОДЕЛИ ОСТРОЙ ГИПЕРЛИПИДЕМИИ, ИНДУЦИРОВАННОЙ ЭТАНОЛОМHYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOLРодноваЕ. А.RodnovaE. A.ivanovvv.1953@qip.ruИвановВ. В.IvanovV. V.ivanovvv.1953@qip.ruЛедюковаС. И.LedyukovaS. I.ivanovvv.1953@qip.ruЧучалинВ. С.ChuchalinV. S.ivanovvv.1953@qip.ruРатькинА. В.RatkinA. V.ivanovvv.1953@qip.ruРахимоваБ. Б.RakhimovaB. B.ivanovvv.1953@qip.ruХабаровА. А.KhabarovI. A.ivanovvv.1953@qip.ruАдекеновС. М.AdekenovS. M.ivanovvv.1953@qip.ruСибирский государственный медицинский университет, ТомскРоссияSiberian Medical University, TomskRussian FederationМеждународный научно-производственный холдинг „Фитохимия“, КарагандаКазахстанInternational scientific-industrial holding "Phytochemistry ", KaragandaKazakhstan2013280220131214348Copyright © Роднова Е.А., Иванов В.В., Ледюкова С.И., Чучалин В.С., Ратькин А.В., Рахимова Б.Б., Хабаров А.А., Адекенов С.М., 20132013Роднова Е.А., Иванов В.В., Ледюкова С.И., Чучалин В.С., Ратькин А.В., Рахимова Б.Б., Хабаров А.А., Адекенов С.М.Rodnova E.A., Ivanov V.V., Ledyukova S.I., Chuchalin V.S., Ratkin A.V., Rakhimova B.B., Khabarov I.A., Adekenov S.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/9

Леукомизин на модели острой гиперлипидемии у крыс, индуцированной введением этанола, снижает уровень свободных жирных кислот и триацилглицеролов в сыворотке крови, а также содержание триацилглицеролов в печени экспериментальных животных. Введение сесквитерпеноида леукомизина повышает активность ферментов антиперекисной защиты – глутатионредуктазы и глутатионпероксидазы, уровень общего и восстановленного глутатиона, что препятствует активации перекисного окисления липидов в печени, вызванной этанолом. Гиполипидемический эффект леукомизина при индуцированной гиперлипидемии может быть обусловлен ингибирующим влиянием на липолиз в жировой ткани, как это наблюдается при применении никотиновой кислоты. Наряду с этим леукомизин оказывает антиоксидантное действие, обусловленное активацией ферментов антиперекисной защиты и увеличением редокс-потенциала системы глутатиона в печени крыс

 

Leucomisine model of acute hyperlipidemia in rats induced by administration of ethanol reduces the levels of free fatty acids and triacylglycerols in serum and the content of triacylglycerols in the liver of experimental animals. Introduction sesquiterpenoid leucomisine increases the activity of enzymes antiperoxidant protecti- on – glutathione peroxidase and glutathione reductase and the level of total and reduced glutathione, which prevents the activation of lipid peroxidation in the liver caused by ethanol. Lipid-lowering effect induced by the hyperlipidemia leucomisine when, like nicotinic acid, may be due to an inhibitory effect on lipolysis in adipose tissue. Along with this leucomisine has an antioxidant effect due to the activation of enzymes antiperoxidant protect and increase the redox potential of glutathione in the liver of rats. 

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The authors declare that there are no conflicts of interest present.