ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2014-6-10-19ssmu-92Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSКЛИНИЧЕСКОЕ СОСТОЯНИЕ И ХЕМИЛЮМИНЕСЦЕНТНАЯ АКТИВНОСТЬ НЕЙТРОФИЛЬНЫХ ГРАНУЛОЦИТОВ БОЛЬНЫХ РАСПРОСТРАНЕННЫМ ГНОЙНЫМ ПЕРИТОНИТОМ В ДИНАМИКЕ ПОСЛЕОПЕРАЦИОННОГО ПЕРИОДАCLINICAL STATUS AND CHEMILUMINESCENT ACTIVITY OF NEUTROPHILS IN PATIENTS WITH ADVANCED PURULENT PERITONITIS IN THE DYNAMICS OF POSTOPERATIVE PERIODСавченкоА. А.SavchenkoA. A.

Савченко Андрей Анатольевич – доктор медицинских наук, профессор, руководитель лаборатории молекулярно-клеточной физиологии и патологии 

aasavchenko@yandex.ruЧерданцевД. В.CherdantsevD. V.

Черданцев Дмитрий Владимирович – доктор медицинских наук, профессор зав. кафедрой и клиникой хирургических болезней им. проф. А.М. Дыхно 

aasavchenko@yandex.ruПервоваО. В.PervovaO. V.

Первова Ольга Владимировна – доктор медицинских наук, доцент кафедры и клиники хирургических болезней им. проф. А.М. Дыхно

aasavchenko@yandex.ruГвоздевИ. И.GvozdevI. I.

Гвоздев Иван Игоревич – младший научный сотрудник лаборатории молекулярно-клеточной физиологии и патологии

aasavchenko@yandex.ruБорисовА. Г.BorisovA. G.

Борисов Александр Геннадьевич– кандидат медицинских наук, вед. научный сотрудник лаборатории молекулярно-клеточной физиологии и патологии 

aasavchenko@yandex.ruШапкинаВ. А.ShapkinaV. A.

Шапкина Валерия Анатольевна– ассистент кафедры и клиники хирургических болезней им. проф. А.М. Дыхно

aasavchenko@yandex.ruНИИ медицинских проблем Севера СО РАМН, КрасноярскРоссияInstitute of Medical Problems of the North, Siberian Branch of Russian Academy of Medical Sciences, KrasnoyarskRussian FederationКрасноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого, КрасноярскРоссияKrasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky, KrasnoyarskRussian Federation2014281220141361019Copyright © Савченко А.А., Черданцев Д.В., Первова О.В., Гвоздев И.И., Борисов А.Г., Шапкина В.А., 20142014Савченко А.А., Черданцев Д.В., Первова О.В., Гвоздев И.И., Борисов А.Г., Шапкина В.А.Savchenko A.A., Cherdantsev D.V., Pervova O.V., Gvozdev I.I., Borisov A.G., Shapkina V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/92перитонитнейтрофилыхемилюминесценцияактивные формы кислородасупероксид-радикалperitonitisneutrophil chemiluminescencereactive oxygen speciesReferencesБойко В.В., Криворучко И.А., Тесленко С.Н., Сивожеле-зов А.В. Распространенный гнойный перитонит. Харьков: Прапор, 2008. 280 с.Boiko V.V., Krivoruchko I.A., Teslenko S.N., Sivozhelezov A.V. Rasprostranennyj gnojnyj peritonit [Generalized purulent peritonitis]. Kharkov, Prapor Publ., 2008. 280 p. (in Russian).Piraino B. Today's approaches to prevent peritonitis // Contrib. Nephrol. 2012. V. 178. P. 246–250.Piraino B. Today's approaches to prevent peritonitis. Contrib. Nephrol., 2012, vol. 178, pp. 246–250.Савченко А.А., Здзитовецкий Д.Э., Борисов А.Г., Лузан Н.А. Особенности состояния клеточного и гуморального иммунитета у больных с распространенным гнойным перитонитом // Бюл. Восточно-Сибирского научного центра СО РАМН. 2012. № 3. С. 159–163.Savchenko A.A., Zdzitovetsky D.E., Borisov A.G., Luzan N.A. Osobennosti sostojanija kletochnogo i gumoral'nogo immuniteta u bol'nyh s rasprostranennym gnojnym peritonitom [Peculiarities of cellular and humoral immunity status in patients with extensive purulent peritonitis]. Bjulleten' Vostochno-Sibirskogo nauchnogo centra SO RAMN, 2012, no. 3, pp. 159–163 (in Russian).Савченко А.А., Здзитовецкий Д.Э., Борисов А.Г. Иммунометаболические нарушения при распространенном гнойном перитоните. Новосибирск: Наука, 2013. 142 с.Savchenko A.A., Zdzitovetsky D.E., Borisov A.G. Immunometabolicheskie narushenija pri rasprostranennom gnojnom peritonite [Immunometabolic violations during generalized purulent peritonitis]. Novosibirsk, Science Publ., 2013. 142 p. (in Russian).Schietroma M., Piccione F., Carlei F., Sista F., Cecilia E.M., Amicucci G. Peritonitis from perforated peptic ulcer and immune response // J. Invest. Surg. 2013. V. 26, № 5. P. 294–304.Schietroma M., Piccione F., Carlei F., Sista F., Cecilia E.M., Amicucci G. Peritonitis from perforated peptic ulcer and immune response. J. Invest. Surg., 2013, vol. 26, no. 5, pp. 294–304.Sista F., Schietroma M., Abruzzese V., Bianchi Z., Carlei F., De Santis G., Cecilia E.M., Pessia B., Piccione F., Amicucci G. Ultrasonic versus standard electric dissection in laparoscopic cholecystectomy in patients with acute calculous cholecystitis, complicated by peritonitis: influence on the postoperative systemic inflammation and immune response. A prospective randomized study // J. Laparoendosc. Adv. Surg. Tech. A. 2014. V. 24, № 3. P. 151–158.Sista F., Schietroma M., Abruzzese V., Bianchi Z., Carlei F., De Santis G., Cecilia E.M., Pessia B., Piccione F., Amicucci G. Ultrasonic versus standard electric dissection in laparoscopic cholecystectomy in patients with acute calculouscholecystitis, complicated by peritonitis: influence on the postoperative systemic inflammation and immune response. A prospective randomized study. J. Laparoendosc. Adv. Surg. Tech. A., 2014, vol. 24, no. 3, pp. 151–158.Савченко А.А., Борисов А.Г. Основы клинической иммунометаболомики. Новосибирск: Наука, 2012. 263 с.Savchenko A.A., Borisov A.G. Osnovy klinicheskoi immunometabolomiki [Basis of clinical immunometabolomics]. Novosibirsk, Science Publ., 2012. 263 p. (in Russian).Minar P., Haberman Y., Jurickova I., Wen T., Rothenberg M.E., Kim M.O., Saeed S.A., Baldassano R.N., Stephens M., Markowitz J., Rosh J., Crandall W.V., Heyman M.B., Mack D.R, Griffiths A.M., Baker S.S., Hyams J.S., Kugathasan S., Denson L.A. Utility of Neutrophil Fcγ Receptor I (CD64) Index as a Biomarker for Mucosal Inflammation in Pediatric Crohn's Disease // Inflamm. Bowel Dis. 2014. V. 20, № 6. P. 1037–1048.Minar P., Haberman Y., Jurickova I., Wen T., Rothenberg M.E., Kim M.O., Saeed S.A., Baldassano R.N., Ste-phens M., Markowitz J., Rosh J., Crandall W.V., Heyman M.B., Mack D.R, Griffiths A.M., Baker S.S., Hyams J.S., Kugathasan S., Denson L.A. Utility of Neutrophil Fcγ Re-ceptor I (CD64) Index as a Biomarker for Mucosal Inflam-mation in Pediatric Crohn's Disease. Inflamm. Bowel Dis., 2014, vol. 20, no. 6, pp. 1037–1048.Taylor A., Tang W., Bruscia E.M., Zhang P.X., Lin A., Gaines P., Wu D., Halene S. SRFis required for neutrophil migration in response to inflammation // Blood. 2014. V. 123, № 19. P. 3027–3036.Taylor A., Tang W., Bruscia E.M., Zhang P.X., Lin A., Gaines P., Wu D., Halene S. SRFis required for neutrophil migration in response to inflammation. Blood, 2014, vol. 123, no. 19, pp. 3027–3036.Wright H.L., Moots R.J., Bucknall R.C., Edwards S.W. Neutrophil function in inflammation and inflammatory diseases // Rheumatology (Oxford). 2010. V. 49, № 9. P. 1618–1631.Wright H.L., Moots R.J., Bucknall R.C., Edwards S.W. Neutrophil function in inflammation and inflammatory diseases. Rheumatology (Oxford), 2010, vol. 49, no. 9, pp. 1618–1631.Куртасова Л.М., Савченко А.А., Шкапова Е.А. Клинические аспекты функциональных нарушений нейтрофильных гранулоцитов при онкопатологии. Новосибирск: Наука, 2009. 184 с.Kurtasova L.M., Savchenko A.A., Shkapova Ye.A. Klinicheskie aspekty funkcional'nyh narushenii nejtrofil'nyh granulocitov pri onkopatologii [Clinical aspects of functional disorders of polymorphonuclear granulocytes in oncopathology]. Novosibirsk, Science Publ., 2009. 184 p. (in Russian).Kasama T., Miwa Y., Isozaki T. Neutrophil-derived cyto-kines: potential therapeutic targets in inflammation // Curr. Drug. Targets Inflamm. Allergy. 2005. V. 4, № 3. P. 273–279.Kasama T., Miwa Y., Isozaki T. Neutrophil-derived cyto-kines: potential therapeutic targets in inflammation. Curr. Drug. Targets Inflamm. Allergy, 2005, vol. 4, no. 3, pp. 273–279.Владимиров Ю.А., Проскурина Е.В. Свободные радикалы и клеточная хемилюминесценция // Успехи биологической химии. 2009. № 49. С. 341–388.Vladimirov Yu.A., Proskurina Ye.V. Svobodnye radikaly i kletochnaja hemiljuminescencija [Free radicals and cellular chemiluminescence]. Uspehi biologicheskoj himii, 2009, no. 49, pp. 341–388 (in Russian).Reina E., Al-Shibani N., Allam E., Gregson K.S., Kowolik M., Windsor L.J. The Effectsof Plantago major on the Activation of the Neutrophil Respiratory Burst // J. Tradit. Complement. Med. 2013. V. 3, № 4. P. 268–272.Reina E., Al-Shibani N., Allam E., Gregson K.S., Kowolik M., Windsor L.J. The Effectsof Plantago major on the Activation of the Neutrophil Respiratory Burst. J. Tradit. Complement. Med., 2013, vol. 3, no. 4, pp. 268–272.Santos E.O., Kabeya L.M., Figueiredo-Rinhel A.S., Marchi L.F., Andrade M.F., Piatesi F., Paoliello-Paschoalato A.B., Azzolini A.E., Lucisano-Valim Y.M. Flavonols modulate the effector functions of healthy individuals' immune complex-stimulated neutrophils: A therapeutic perspective for rheumatoid arthritis // Int. Immuno-pharmacol. 2014. V. 21, № 1. P. 102–111.Santos E.O., Kabeya L.M., Figueiredo-Rinhel A.S., Marchi L.F., Andrade M.F., Piatesi F., Paoliello-Paschoalato A.B., Azzolini A.E., Lucisano-Valim Y.M. Flavonols modulate the effector functions of healthy individuals' immune complex-stimulated neutrophils: A therapeutic perspective for rheumatoid arthritis. Int. Immunopharmacol., 2014, vol. 21, no. 1, pp. 102–111.Le Gall J.-R., Lemeshow S., Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European / North American multicenter study // JAMA. 1993. V. 270. P. 2957–2963.Le Gall J.-R., Lemeshow S., Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a Europe-an/North American multicenter study. JAMA, 1993, vol. 270, pp. 2957–2963.Bone R.S., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., Schein R.M., Sibbald W.J. American college of Chest Physicians. Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guide lines for the use of innovative therapies in sepsis // Crit. Care Med. 1992. V. 20, № 6. P. 864–874.Bone R.S., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., Schein R.M., Sibbald W.J. American college of Chest Physicians. Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guide lines for the use of innovative therapies in sepsis. Crit. Care Med., 1992, vol. 20, no. 6, pp. 864–874.Linder M.M., Wacha H., Feldmann U., Wesch G., Streifensand R.A., Gundlach E. Der Mann–heimer Peritonitis-Index. Ein Instrument zurintraoperativenPrognose der Peritonitis // Chirurg. 1987. V. 58. P. 84–91.Linder M.M., Wacha H., Feldmann U., Wesch G., Streifensand R.A., Gundlach E. Der Mann–heimer Peritonitis-Index. Ein Instrument zurintraoperativen Prognose der Peritonitis. Chirurg., 1987, vol. 58, pp. 84–91.Vincent J.L., Moreno R., Takala J., Willatts S., De Mendonça A., Bruining H., Reinhart C.K., Suter P.M., Thijs L.G. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine // Intensive Care Med. 1996. V. 22, № 7. P. 707–710.Vincent J.L., Moreno R., Takala J., Willatts S., De Mendonça A., Bruining H., Reinhart C.K., Suter P.M., Thijs L.G. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med., 1996, vol. 22, no. 7, pp. 707–710.Коленчукова О.А., Савченко А.А., Смирнова С.В. Особенности люминол- и люцигенин-зависимой хемилюминесценции нейтрофильных гранулоцитов у больных хроническим риносинуситом // Мед. иммунология. 2010. Т. 12, № 4–5. С. 437–440.Kolenchukova O.A., Savchenko A.A., Smirnova S.V. Osobennosti ljuminol- i ljucigenin-zavisimoj hemiljuminescencii nejtrofil'nyh granulocitov u bol'nyh hronicheskim rinosinusitom [Features of luminol- and lucigenin-induced chemiluminescence of neutrophilic granulocytes in patients with chronic rhinosinusitis]. Medicinskaya immunologiya – Russian Journal of Medical Immunology, 2010, vol. 12, no. 4–5, pp. 437–440 (in Russian).Савченко А.А., Здзитовецкий Д.Э., Борисов А.Г., Лузан Н.А. Хемилюминесцентная активность нейтрофильных гранулоцитов и уровни концентрации цитокинов у больных распространенным гнойным перитонитом // Цитокины и воспаление. 2013. Т. 12, № 1–2. С. 115–119.Savchenko A.A., Zdzitovecky D.Ye., Borisov A.G., Luzan N.A. Hemiljuminescentnaya aktivnost' nejtrofil'nyh granulocitov i urovni koncentracii citokinov u bol'nyh rasprostranennym gnojnym peritonitom [Neutrophil chemiluminescent activity and cytokine concentration levels in patients with extensive purulent peritonitis]. Citokiny i vospalenie – Cytokines & inflammation, 2013, vol. 12, no. 1–2, pp. 115–119 (in Russian).Kumar V., Everingham S., Hall C., Greer P.A., Craig A.W. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model // Eur. J. Immunol. 2014. V. 44, № 3. P. 831–841.Kumar V., Everingham S., Hall C., Greer P.A., Craig A.W. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur. J. Immunol., 2014, vol. 44, no. 3, pp. 831–841.Martino F.K., Filippi I., Giavarina D., Kaushik M., Rodighiero M.P., Crepaldi C., Teixeira C., Nadal A.F., Rosner M.H., Ronco C. Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of neutrophil gelatinase-associated lipocalin // Contrib. Nephrol. 2012. V. 178. P. 258–263.Martino F.K., Filippi I., Giavarina D., Kaushik M., Rodighiero M.P., Crepaldi C., Teixeira C., Nadal A.F., Rosner M.H., Ronco C. Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of neutrophil gelatinase-associated lipocalin. Contrib. Nephrol., 2012, vol. 178, pp. 258–263.Khan P., Idrees D., Moxley M.A., Corbett J.A., Ahmad F., von Figura G., Sly W.S., Waheed A., Hassan M.I. Lumi-nol-based chemiluminescent signals: clinical and non-clinical application and future uses // Appl. Biochem. Biotechnol. 2014. V. 173, № 2. P. 333–355.Khan P., Idrees D., Moxley M.A., Corbett J.A., Ahmad F., von Figura G., Sly W.S., Waheed A., Hassan M.I. Luminol-based chemiluminescent signals: clinical and non-clinical application and future uses. Appl. Biochem. Biotechnol., 2014, vol. 173, no. 2, pp. 333–355.

The authors declare that there are no conflicts of interest present.