References

ssmu

Бюллетень сибирской медицины

Bulletin of Siberian Medicine

1682-03631819-3684

Siberian State Medical University, the Ministry of Healthcare of the Russian Federation

10.20538/1682-0363-2014-1-135-144

ssmu-93

Research Article

ОБЗОР ЛИТЕРАТУРЫ

LITERATURE REVIEW

ВОЗМОЖНОСТИ БИОМЕДИЦИНСКОГО ПРИМЕНЕНИЯ УГЛЕРОДНЫХ НАНОТРУБОК

OPPORTUNITIES OF BIOMEDICAL USE OF CARBON NANOTUBES

Митрофанова

И. В.

Mitrofanova

I. V.

Митрофанова Ирина Валерьевна, студентка 5-го курса медико-биологического факультета СибГМУ

v.georgiy@mail.ru

Мильто

В. И.

Milto

I. V.

Мильто Иван Васильевич, кандидит биологических наук, доцент кафедры морфологии и общей патологии СибГМУ, ст. преподаватель кафедры биотехнологии и органической химии НИ ТПУ

v.georgiy@mail.ru

Суходоло

И. В.

Suhodolo

I. V.

Суходоло Ирина Владимировна, доктор медицинских наук, профессор, зав. кафедрой морфологии и общей патологии СибГМУ

v.georgiy@mail.ru

Васюков

Г. Ю.

Vasyukov

G. Yu.

Васюков Георгий Юрьевич, аспирант кафедры морфологии и общей патологии СибГМУ, лаборант исследователь лаборатории ультраструктурных исследований НИИ КПССЗ СО РАМН

v.georgiy@mail.ru

Сибирский государственный медицинский университет, ТомскРоссияSiberian State Medical University, TomskRussian Federation

Сибирский государственный медицинский университет, Томск; Национальный исследовательский Томский политехнический университет, ТомскРоссияSiberian State Medical University, Tomsk; National Research Tomsk Polytechnic UniversityRussian Federation

Сибирский государственный медицинский университет, Томск; Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАМН, КемеровоРоссияSiberian State Medical University, Tomsk; Institute of Complex Problems of Cardio-Vascular Diseases, Siberian Branch of Russian Academy of Medical Science, KemerovoRussian Federation

2014

28022014

131135144

2014

Митрофанова И.В., Мильто В.И., Суходоло И.В., Васюков Г.Ю.

Mitrofanova I.V., Milto I.V., Suhodolo I.V., Vasyukov G.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://bulletin.ssmu.ru/jour/article/view/93

Сибирский государственный медицинский университет, Томск, Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАМН, КемеровоНаноматериалы – материалы, содержащие структурные элементы, размеры которых в одном из измерений не превышают 100 нм. При переходе в ультрадисперсное состояние вещества приобретают качественно новые свойства. В последнее десятилетие наиболее популярным типом наноматериалов являются углеродные нанотрубки, которые привлекают внимание представителей различных научных направлений. Развитие фундаментальных и прикладных представлений об углеродных нанотрубках уже в ближайшие годы может привести к кардинальным изменениям в материаловедении, электронике, биологии, медицине и экологии.Углеродные нанотрубки открывают новые возможности для биологического и медицинского применения: визуализация молекулярных, клеточных и тканевых структур; создание биосенсоров и электродов на их основе; целевая доставка разнообразных веществ; лучевая и фототермическая терапия. Наиболее перспективным свойством углеродных нанотрубок в контексте биомедицинского применения является их способность проникать в различные ткани организма и переносить большие дозы агентов, оказывая терапевтический и диагностический эффекты. Кроме того, функционализированные углеродные нанотрубки являются биодеградируемыми. Благодаря этим преимуществам нанотрубки являются перспективной основой для систем целевой доставки различных веществ. Другим актуальным направлением использования углеродных нанотрубок в медицине и биологии является визуализация объектов на молекулярном, клеточном и тканевом уровнях. Связанные с углеродными нанотрубками контрастирующие вещества улучшают визуализацию клеток, что позволяет выявлять новые закономерности развития патологического процесса.В связи с неясностью вопроса биосовместимости и цитотоксичности углеродных нанотрубок возможность их практического применения тормозится. Перед внедрением углеродных нанотрубок в практическое здравоохранение необходимо предусмотреть все возможные последствия их использования. Высокие темпы изучения свойств и разработка новых наноконструкций на основе углеродных нанотрубок в ближайшее время приведут к новым успехам, связанным с применением и разработкой новых параметров, которые будут определять их свойства и эффекты. В обзоре рассматривается строение, физико-химические свойства нанотрубок, их функционализация, фармококинетика и основные аспекты использования углеродных нанотрубок.

Nanomaterials – materials, whouse structure elements has proportions doesn’t exceed 100 nm. In superdispersed state matter acquire new properties. In the last decade, carbon nanotubes become the most popular nanomaterials, that cause attention of representatives of various scientific field. The сarbon nanotubes offer new opportunities for biological and medical applications: imaging at the molecular, cellular and tissue levels, biosensors and electrodes based on carbon nanotubes, target delivery of various substances, radiation and photothermal therapy. The most promising of carbon nanotubes in the context of biomedical applications is their ability to penetrate the various tissues of the body and carry large doses of agents, providing diagnostic and therapeutic effects. Functionalized nanotubes are biodegradable. Other current direction of using carbon nanotubes in medicine and biology is to visualize objects on the molecular, cellular and tissue level. Associated with carbon nanotubes contrasting substances improve the visualization of cells and tissues, which can detected new patterns of development of the pathological process. Due to the vagueness of the question of biocompatibility and cytotoxicity of carbon nanotubes possibility of their practical application is hampered. Before the introduction of carbon nanotubes into practical health care is necessary to provide all the possible consequences of using nanotubes. High rates of properties and development of new nanostructures based on carbon nanotubes in the near future will lead to new advances related to the application and development of new parameters that will determine their properties and effects. In these review attention is paid to the structure, physico-chemical properties of nanotubes, their functionalization, pharmacokinetics and pharmacodynamics and all aspects of using of carbon nanotubes.

ультрадисперсные материалынаночастицыклеточная биологиянанотоксикологиянаноматериалы на основе углерода

ultradisperse materialsnanoparticlescell biologynanotoxicologycarbon-based nanomaterials

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The authors declare that there are no conflicts of interest present.