ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2014-1-153-160ssmu-95Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWРОЛЬ СООБЩЕСТВА МИКРООРГАНИЗМОВ ДЫХАТЕЛЬНЫХ ПУТЕЙ В ПАТОГЕНЕЗЕ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХTHE ROLE OF MICROBIAL COMMUNITIES OF AIRWAYS IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASEФедосенкоС. В.FedosenkoS. V.

Федосенко Сергей Вячеславович,  кандидат медицинских наук, докторант кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины

s-fedosenko@mail.ruОгородоваЛ. М.OgorodovaL. M.

Огородова Людмила Михайловна, доктор медицинских наук, профессор, член-корреспондент РАМН, зав. кафедрой факультетской педиатрии с курсом детских болезней лечебного факультета

s-fedosenko@mail.ruКарнаушкинаМ. А.KarnaushkinaM. A.

Карнаушкина Мария Александровна, кандидат медицинских наук, ассистент кафедры пульмонологии

s-fedosenko@mail.ruКуликовЕ. С.KulikovYe. S.

Куликов Евгений Сергеевич, кандидат медицинских наук, докторант кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины

s-fedosenko@mail.ruKulikovДеевИ. А.DeyevI. A.

Деев Иван Анатольевич, доктор медицинских наук, профессор кафедры факультетской педиатрии с курсом детских болезней лечебного факультета

s-fedosenko@mail.ruКирилловаН. А.KirillovaN. A.

Кириллова Наталья Александровна, кандидат медицинских наук, ассистент кафедры общей врачебной практики и поликлинической терапии ФПК и ППС СибГМУ

s-fedosenko@mail.ruСибирский государственный медицинский университет, ТомскРоссияSiberian State Medical University, TomskRussian FederationМосковский государственный медико-стоматологический университет имени А.И. Евдокимова, МоскваРоссияMoscow State Medical and Dental University named after A.I. Yevdokimov, MoscowRussian Federation201428022014131153160Copyright © Федосенко С.В., Огородова Л.М., Карнаушкина М.А., Куликов Е.С., Деев И.А., Кириллова Н.А., 20142014Федосенко С.В., Огородова Л.М., Карнаушкина М.А., Куликов Е.С., Деев И.А., Кириллова Н.А.Fedosenko S.V., Ogorodova L.M., Karnaushkina M.A., Kulikov Y.S., Deyev I.A., Kirillova N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/95

В обзоре обобщены результаты исследований, посвященных изучению состава сообщества микроорганизмов в дыхательных путях у здоровых лиц и пациентов с хронической обструктивной болезнью легких. Современные технологии молекулярно-генетической идентификации микроорганизмов позволяют выполнить глубокий анализ микробиоты респираторного тракта, что представляет значительный интерес как для определения роли микробиома в развитии заболеваний бронхолегочной системы человека, так и для понимания влияния микробиотических сообществ на особенности течения болезни и ее прогрессирования, а также эффективности проводимой терапии.

This review summarizes the results of studies on the composition of microbial communities in the airways of healthy subjects and in patients with chronic obstructive pulmonary disease. Modern technologies of molecular-genetic identification methods of microorganisms allow to perform a deep analysis  of  the  respiratory  microbiom.  It  is  of  considerable  interest  to  determine  the  role  of  the microbiome in the development of human diseases of the bronchopulmonary system, and to understand the impact of the microbes communities as a course of disease and the important factor for the efficacy of current therapy.

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The authors declare that there are no conflicts of interest present.