ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2017-3-192-209ssmu-970Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРазработка бинарных технологий лучевой терапии злокачественных новообразований: состояние и проблемыDevelopment of binary technologies of radiotherapy of malignant neoplasms: condition and problemsШейноИгорь НиколаевичSheinoIgor N.

канд. физ.-мат. наук, зав. лабораторией, ГНЦ ФМБЦ им. А.И. Бурназяна, г. Москва.

PhD, Head of Laboratory, A.I. Burnazian Federal Medical Biophysical Center, Moscow, Russian Federation

ИжевскийПавел ВладимировичIzhevskijPavel V.

канд. мед. наук, доцент, вед. науч. сотрудник, ГНЦ ФМБЦ им. А.И. Бурназяна, г. Москва.

PhD, Leading Researcher, A.I. Burnazian Federal Medical Biophysical Center, Moscow, Russian Federation.

izhevsky09@gmail.comЛипенгольцАлексей АндреевичLipengoltsAlexey A.

канд. физ.-мат. наук, ст. науч. сотрудник, ГНЦ ФМБЦ им. А.И. Бурназяна, г. Москва.

PhD, Senior Researcher, A.I. Burnazian Federal Medical Biophysical Center, Moscow, Russian Federation

КулаковВиктор НиколаевичKulakovVictor N.

д-р хим. наук, вед. науч. сотрудник, ГНЦ ФМБЦ им. А.И. Бурназяна, г. Москва.

DChSc, Leading Researcher, A.I. Burnazian Federal Medical Biophysical Center, Moscow, Russian Federation.

ВагнерАлександр РудольфовичWagnerAlexander A.

канд. физ.-мат. наук, НИ ТПУ, г. Томск.

PhD, Head of Laboratory, National Research Tomsk Polytechnic University, Russian Federation

СухихЕвгения СергеевнаSukhikhEvgeniya S.

канд. физ.-мат. наук, медицинский физик, ТООД; ст. преподаватель, НИ ТПУ, г. Томск.

PhD, Tomsk Regional Oncology Center, Medical Physicist; Senior Lecturer, National Research Tomsk Polytechnic University, Russian Federation

ВарлачевВалерий АлександровичVarlachevValery A.

д-р техн. наук, профессор, зав. лабораторией, НИ ТПУ, г. Томск.

DTSc, Professor, Head of Laboratory, National Research Tomsk Polytechnic University, Russian Federation.

Государственный научный центр Федеральный медицинский биофизический центр (ГНЦ ФМБЦ) им. А.И. БурназянаРоссияA.I. Burnazian Federal Medical Biophysical CenterRussian FederationНациональный исследовательский Томский политехнический университет (НИ ТПУ)РоссияNational Research Tomsk Polytechnic UniversityRussian FederationНациональный исследовательский Томский политехнический университет (НИ ТПУ); Томский областной онкологический диспансер (ТООД)РоссияNational Research Tomsk Polytechnic University; Tomsk Regional Oncology CenterRussian Federation201731102017163192209Copyright © Шейно И.Н., Ижевский П.В., Липенгольц А.А., Кулаков В.Н., Вагнер А.Р., Сухих Е.С., Варлачев В.А., 20172017Шейно И.Н., Ижевский П.В., Липенгольц А.А., Кулаков В.Н., Вагнер А.Р., Сухих Е.С., Варлачев В.А.Sheino I.N., Izhevskij P.V., Lipengolts A.A., Kulakov V.N., Wagner A.A., Sukhikh E.S., Varlachev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/970

Обзор посвящен проблемам развития бинарных технологий лучевой терапии – нейтрон- и фотон-захватной терапии злокачественных новообразований. В технологиях используется принцип биологического нацеливания: облучение опухоли с предварительно доставленными в нее специальными препаратами, повышающими выделение энергии и относительную биологическую эффективность первичного излучения. Описаны основы методов, характеристики источников внешнего облучения и используемых препаратов, этапы разработки технологий. Развитие и внедрение бинарных технологий привлекает большое количество исследователей, но сдерживается нехваткой действующих источников эпитепловых нейтронов (реакторов, генераторов нейтронов на основе ускорителей), отсутствием корректных систем дозиметрического планирования лучевой терапии с учетом динамики и накопления препаратов в опухолях.

The review is devoted to the problems of the development of binary technologies of radiation therapy - neutron and photon-capture therapy of malignant neoplasms. These technologies are based on the principle of “biological” targeting: irradiation of a tumor with pre-delivered special preparations increasing energy release and the relative biological efficiency of primary radiation. The basis of methods, characteristics of sources of external irradiation and used preparations, and stages of development of technologies are described. The development and implementation of binary technologies attract a great number of researchers but are restrained by the shortage of operating sources of epithermal neutrons (reactors, neutron generators based on accelerators) and the lack of accurate radiation dosimetry planning systems that takes into account the dynamics and accumulation of drugs in tumors.

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The authors declare that there are no conflicts of interest present.