STUDY CARDIOTOXIC PROPERTIES OF NATIVE PEAT HUMIC ACIDS
https://doi.org/10.20538/1682-0363-2014-1-14-19
Abstract
The earlier pathomorphological studies of toxic properties of peat humic acids (PHAs) at intraperitoneal injection revealed that one of the causes of lethality is the direct cardiotoxic action of PHAs. For the further study of the mechanism of cardiotoxic action, electrocardiogram was recorded and ventricular fibrillation threshold was determined in male rats after intraperitoneal injection of humic acids in knowingly lethal dose – 480 mg/kg bwt. A single intraperitoneal injection of PHA to rats in knowingly lethal dose caused a significant decrease of the ventricular fibrillation threshold in comparison with intact animals. It was found that the PHA injection exerted no significant effect on the heart rate in rats and change of the PQ, QT, and QTc intervals. At the same time, the significant shortening of the QRS complex in comparison with intact animals was observed. Judging from the results obtained, the single injection of humic acids in the lethal dose induced a decrease in the electrical stability of heart, as evidenced by the drop of the ventricular fibrillation threshold. This decrease of the electrical stability of heart can be a cause of sudden cardiac death of trial rats. Disorder of the heart electrical stability is likely connected with the ionophoric action of humic acids and change of electrophysiological properties of cell membranes.
About the Authors
M. V. Belousov
Siberian State Medical University, Tomsk
Russian Federation
Belousov Michael V.
Russian Federation
Belousov Michael V.
R. R. Akhmedzhanov
Tomsk Polytechnic University, Tomsk
Russian Federation
Akhmedzhanov Rafik R.
Russian Federation
Akhmedzhanov Rafik R.
M. V. Zykova
Siberian State Medical University, Tomsk
Russian Federation
Zykova Maria V.
Russian Federation
Zykova Maria V.
L. N. Maslov
Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk
Russian Federation
Maslov Leonid N.
Russian Federation
Maslov Leonid N.
A. M. Guriyev
Siberian State Medical University, Tomsk
Russian Federation
Guriyev Artem M.
Russian Federation
Guriyev Artem M.
M. S. Yusubov
Siberian State Medical University, Tomsk; Tomsk Polytechnic University, Tomsk
Russian Federation
Yusubov Mehman S.
Russian Federation
Yusubov Mehman S.
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Review
For citations:
Belousov M.V., Akhmedzhanov R.R., Zykova M.V., Maslov L.N., Guriyev A.M., Yusubov M.S. STUDY CARDIOTOXIC PROPERTIES OF NATIVE PEAT HUMIC ACIDS. Bulletin of Siberian Medicine. 2014;13(1):14-19. (In Russ.) https://doi.org/10.20538/1682-0363-2014-1-14-19
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