The regulation of epithelial cells volume in norm and pathology
https://doi.org/10.20538/1682-0363-2017-4-42-60
Abstract
The ability to regulate volume in response to changes in intracellular and extracellular osmolarity is one of the fundamental cell functions. Cell volume changes stimulate a variety of intracellular signaling cascades that activate protective and adaptive mechanisms. In general, the regulation of volume occurs due to the transport of osmolytes, which results in the restoration of the intracellular water volume and the normalization of cellular functions. In this review we focused on the physiological significance of regulatory volume decrease (RVD) and regulatory volume increase (RVI) in response to fluctuations of extra- and intracellular osmolarity in the context of epithelial cells.
About the Authors
O. O. Ponomarchuk
M.V. Lomonosov Moscow State University; Centre de Recherche, Centre Hospitalier de l’Université de Montréal (CRCHUM)
Russian Federation
Russian Federation
Faculty of Biology
1/12, Leninskie Gory, 119991, Moscow
900, Tour Viger, rue St-Denis, Montreal, Quebec, H2X 0A9
G. V. Маximov
M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
Faculty of Biology
1/12, Leninskie Gory, 119991, Moscow
S. N. Оrlov
M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
DM, Professor, Faculty of Biology
1/12, Leninskie Gory, 119991, Moscow
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Ponomarchuk O.O., Маximov G.V., Оrlov S.N. The regulation of epithelial cells volume in norm and pathology. Bulletin of Siberian Medicine. 2017;16(4):42-60. (In Russ.) https://doi.org/10.20538/1682-0363-2017-4-42-60
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