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Immunopathogenesis of atopic diseases formation

https://doi.org/10.20538/1682-0363-2017-4-233-241

Abstract

The aim of this investigation is the comparative study of changes in the surface phenotype of lymphocyte in patients with different forms of atopic diseases and latent sensitization.

Materials and methods. The study was conducted on peripheral blood lymphocytes from 22 latent sensitization patients, 30 pollinosis patients, 44 atopic bronchial asthma patients and 36 atopic dermatitis patients. The control group consisted of 26 healthy people.

The results of our studies demonstrate that atopic diseases are different not only in clinical manifestations, but also in mechanisms of disturbances in the functions of the immune system. Comparative study of surface markers of lymphocytes in patients with different forms of atopic diseases revealed a significant increase of surface changes of lymphocyte phenotype according to the severity of the clinical manifestations of the disease. All patients with studied forms of atopy had an increase in content of B-lymphocytes expressing CD72 marker in the peripheral blood and of lymphocytes expressing early activation antigens CD23, CD25, CD71 and adhesion receptor CD54. The developments of pollinosis, atopic bronchial asthma and atopic dermatitis are accompanied by an additional increase levels of lymphocytes expressing the late activation marker HLADR, the CD38+ precursors of plasma cells, and of lymphocytes carrying surface immunoglobulins in peripheral blood. In the blood of patients with atopic disease during exacerbation with evident clinical symptoms revealed a significant increase in all the studied populations and subpopulations of B-lymphocytes. Patients with latent sensitization had increasing blood lymphocytes expressing the CD95 receptor of Fas inducing apoptosis and low content of cells expressing its ligand CD178. Content of CD95+ lymphocytes in peripheral blood at atopic bronchial asthma and atopic dermatitis patients is reduced, and CD178+ lymphocytes increased, reflecting infringement of Fas-dependent apoptosis in severe atopic diseases.

About the Authors

G. V. Poryadin
Pirogov Russian National Research Medical University (PRNRMU)
Russian Federation

DM, Professor, Corresponding Member of RAS, Head of the Department of Pathophysiology and Clinical Pathophysiology

1, Ostrovitianov Str., Moscow, 117997



J. M. Salmasi
Pirogov Russian National Research Medical University (PRNRMU)
Russian Federation

DM, Professor, Pathophysiology and Clinical Pathophysiology Department

1, Ostrovitianov Str., Moscow, 117997



A. N. Kazimirsky
Pirogov Russian National Research Medical University (PRNRMU)
Russian Federation

DBSc, Associate Professor, Leading Engineer of the Toxicology Department

1, Ostrovitianov Str., Moscow, 117997



L. Yu. Semenova
Pirogov Russian National Research Medical University (PRNRMU)
Russian Federation

DM, Associate Professor, Department of Pathophysiology and Clinical Pathophysiology

1, Ostrovitianov Str., Moscow, 117997



References

1. Nagafuku M., Okuyama K., Onimaru Y., Suzuki A., Odagiri Y., Yamashita T., Iwasaki K., Fujiwara M., Takayanagi M., Ohno I., Inokuchi J. CD4 and CD8 T cells require different membrane gangliosides for activation. // Proc. Natl. Acad. Sci. USA. 2012. 109; 6: 336–342.

2. Albacker L.A., Chaudhary V., Chang Y.J., Kim H.Y., Chuang Y.T., Pichavant M., DeKruyff R.H., Savage P.B., Umetsu D.T. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity // Nat. Med. 2013; 19 (10): 1297–1304.

3. Inokuchi J., Nagafuku M., Ohno I., Suzuki A. Distinct selectivity of gangliosides required for CD4⁺ T- and CD8⁺ T-cell activation // Biochim. Biophys. Acta. 2015; 1851 (1): 98–106.

4. Порядин Г.В., Оршанко А.М., Салмаси Ж.М., Казимирский А.Н, Латышева Т.В. Активационные процессы в лимфоцитах пациентов с латентной сенсибилизацией // Патофизиология и экспериментальная терапия. 2009; 1: 3–25. Poryadin G.V., Orshanko A.M., Salmasi J.M., Kazimirskiy A.N., Latysheva T.V. Ak-tivatsionnyye protsessy v limfotsitakh patsiyentov s latentnoy sensibilizatsiyey [Activation processes in lymphocytes of patients with latent sensitization] // Patofiziologiya i eksperimentalnaya terapiya – Pathophysiology and Experimental Therapy. 2009; 1: 3–25 (in Russian).

5. Poryadin G.V., Sharpan Yu.V., Orshanko A.M., Salmasi J.M., Kazimirskiy A.N., Latysheva T.V. Features of the immune status in patients with latent sensitization // Russian Journal of Immunology. 2009; 3 (2): 177–183.

6. Порядин Г.В., Салмаси Ж.М., Казимирский А.Н. Способ оценки ýффективности лечения бронхиальной астмы. Патент на изобретение № 2389023, 2010: 6. Poryadin G.V., Salmasi J.M., Kazimirskiy A.N. Sposob ocenki effektivnosti lecheniya bronkhialnoy astmy [A method of evaluating the effectiveness of treatment of bronchial asthma]. Patent № 2389023, 2010: 6 (in Russian).

7. Wei H., Zhang J., Xiao W., Feng J., Sun R., Tian Z. Involvement of human natural killer cells in asthma pathogenesis: natural killer 2 cells in type 2 cytokine predominance // J. Allergy Clin. Immunol. 2005. 115 (4): 841–847.

8. Poryadin G.V., Zhuravleva N.E., Salmasi J.M., Kazimirskiy A.N., Semenova L.Yu., Polner S.A., Chervinskaya T.A. Immunological Mechanisms of Recovery from an Acute Stage in Patients with Atopic Bronchial Asthma // Russian Journal of Immunology. 2002; 7 (3): 259–264.

9. Салмаси Ж.М., Порядин Г.В., Алиева З.О., Казимирский А.Н. Характеристика поверхностных рецепторов лимфоцитов крови больных атопическим дерматитом // Аллергология и иммунология. 2004; 5 (1): 54–70. Salmasi J.M., Poryadin G.V., Alieva Z.O., Kazimirskiy A.N. Kharakteristika poverkhnostnykh receptorov limfocitov krovi bolnykh atopicheskim dermatitom [Characteristics of surface receptors of blood lymphocytes in patients with atopic dermatitis] // Allergologiya i immunologiya – Allergology and Immunology. 2004; 5 (1): 54–70 (in Russian).

10. Fabian E., Pölöskey P., Kósa L., Elmadfa I., Réthy L.A. Activities of antioxidant enzymes in relation to oxidative and nitrosative challenges in childhood asthma // J. Asthma. 2011; 48 (4): 351–357.

11. Ahmad A., Shameem M., Husain Q. Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma // Ann. Thorac. Med. 2012; 7 (4): 226–232.

12. Fatani S.H. Biomarkers of oxidative stress in acute and chronic bronchial asthma // J. Asthma. 2014; 51 (6): 578–584.

13. Kazimirskiy A.N., Salmasi J.M., Makarov T.V., Poryadin G.V., Terentev A.A. Immune depression effect of oligopeptides from pregnancy specific globulin and carcinoembryonic antigen J. Intern. Socity for Oncoloqy and Biomarkers // Tumor Biology. 2010; 44: 31, ОР-12.

14. Poryadin G.V., Salmasi J.M., Semenova L.Yu. Anti-inflammatory effect of plant composition of Tibetan medicine in vitro on early rheumatoid arthritis // Health. 2011; 3 (9): 560–565.

15. Oflazoglu E., Grewal I.S., Gerber H. Targeting CD30/ CD30L in oncology and autoimmune and inflammatory diseases // Adv. Exp. Med. Biol. 2009; 647: 174–185.

16. Rojas-Ramos E., Garfias Y., Jiménez-Martínez Mdel ., Martínez-Jiménez N., Zenteno E., Gorocica P., Lascurain R. Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report // Allergy Asthma Proc. 2007; 28 (6): 659–666.

17. Беловешкин А.Г. Роль телец Гассаля тимуса человека в позитивной и негативной селекции тимоцитов // Молодой ученый. 2012; 7: 334–338. Beloveshkin A.G. Rol telecz Gassalya timusa cheloveka v pozitivnoy i negativnoy selekcii timocitov [The role of Kassala Taurus thymus of a person in positive and negative selection of thymocytes] // Molodoy uchenyy – Young Scientist. 2012; 7: 334–338 (in Russian).

18. Ярилин А.А., Балабанова Р.М., Латышева Т.В., Никонова М.Ф., Варфоломеева М.И., Григорьева Т.Ю., Станислав М.Л. Неравномерное вовлечение в активационный апоптоз Т-лимфоцитов субклассов CD4+ и CD8+ и высокая чувствительность к нему CD30+ клеток крови здоровых лиц и больных с иммунопато- логией // Иммунология. 2002; 5: 262–267. Yarilin A.A., Balabanova R.M., Latysheva T.V., Nikonova M.F., Varfolomeeva M.I., Grigoreva T.Yu., Stanislav M.L. Neravnomernoe vovlechenie v aktivacionnyy apoptoz T-limfocitov subklassov CD4+ i CD8+ i vysokaya chuvstvitelnost k nemu CD30+ kletok krovi zdorovykh licz i bolnykh s immunopatologiey [Uneven involvement in the activation of apoptosis of T-lymphocytes subclasses of CD4+ and CD8+ and high sensitivity to CD30+ cells in the blood of healthy individuals and patients with immunopathologies] // Immunologiya – Immunology. 2002; 5: 262–267 (in Russian).

19. Romagnani P., Annunziato F., Manetti R., Mavilia C., Lasagni L., Manuelli C., Vannelli G.B., Vanini V., Maggi E., Pupilli C., Romagnani S. High CD30 ligand expression by epithelial cells and hassal”s corpuscles in the medulla of human thymus. // Blood. 1998; 91 (9): 3323–3332.

20. Oflazoglu E., Simpson E.L., Takiguchi R., Grewal I.S., Hanifin J.M., Gerber H.P. CD30 expression on CD1a+ and CD8+ cells in atopic dermatitis and correlation with disease severity. // Eur. J. Dermatol. 2008;18 (1): 41–49.


Review

For citations:


Poryadin G.V., Salmasi J.M., Kazimirsky A.N., Semenova L.Yu. Immunopathogenesis of atopic diseases formation. Bulletin of Siberian Medicine. 2017;16(4):233-241. (In Russ.) https://doi.org/10.20538/1682-0363-2017-4-233-241

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ISSN 1682-0363 (Print)
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