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Modern view on the problem of acute postoperative delirium in trauma and orthopedic patients in the intensive care unit

https://doi.org/10.20538/1682-0363-2018-1-211-219

Abstract

The purpose of the present literature review is a systematization of known evidence on the problem of postoperative delirium as a frequent complication in elderly and senile patients during extensive reconstructive 

surgery on the spine and large joints. The review, which is based on publications of foreign and native authors, provides insights into current understanding of the pathogenesis, risk factors, diagnosis, methods of treatment, and prevention of these complications. The number of operations in traumatology and orthopedy is increasing. Accordingly with this fact, we are seeing an increase the number of cases of postoperative delirium. We know that the risk of delirium is linked with patient age. The interest to this problem is growing and has clinical and economical background. The etiology of delirium is considered to be multivariate. The development of diagnostic tools is playing a very important role and provides control of delirium in intensive care unit. Common understanding of this state’s pathophysiology and the opportunity to participate another physician leads to correct organization of treatment process. The knowledge of acute postoperative delirium in intensive care unit is being formed. The basic concept of postoperative delirium varies from its definition psychiatry and narcology due to differences in how different specialties treat the disorder. The risk factors of treatment are estimated. The controlled sedation is a clear trend. The experience of practical application dexmedetomidin for prevention and treatment of postoperative delirium is accumulated. Although the value of drug- therapy is difficult to overestimate the great influence on the result have non- pharmalogical methods.

About the Authors

I. A. Statsenko
Tsivyan Novosibirsk Research Institute of Traumatology and Orthopaedics (TNRITO) .
Russian Federation

Statsenko Ivan A.,  Doctor Anesthesiologist-Resuscitator.

17, Frunze Str., Novosibirsk, 630091.



S. V. Stegalov
Tsivyan Novosibirsk Research Institute of Traumatology and Orthopaedics (TNRITO) .
Russian Federation

Stegalov Sergey V., Doctor Anesthesiologist-Resuscitator.

17, Frunze Str., Novosibirsk, 630091.



M. N. Lebedeva
Tsivyan Novosibirsk Research Institute of Traumatology and Orthopaedics (TNRITO) .
Russian Federation

Lebedeva Maya N., DM, Deputy Chief Physician for Anesthesia, Chief Research Officer.

17, Frunze Str., Novosibirsk, 630091.



S. A. Pervukhin
Tsivyan Novosibirsk Research Institute of Traumatology and Orthopaedics (TNRITO) .
Russian Federation

Pervukhin Sergey A., PhD, Head of Intensive Care Unit.

17, Frunze Str., Novosibirsk, 630091.



References

1. Koryachkin V.A. Postoperative delirium in orthopedic and traumatological practice: manual for doctors. SPb.: RNIITO Publ., 2013: 24 (in Russ.).

2. Koryachkin V.A. Postoperative delirium: risk factors and prevention in orthopedic and traumatological practice. Travmatolgiya i ortopediya Rossii – Traumatology and Orthopedics of Russia. 2013; 2 (37): 120–135 (in Russ.).

3. Politov M.E., Bastrykin S.Yu., Вulanova E.L., Ovechkin A.M. The influence of anesthesiological tactics on developing of cognitive disorders following endoplastic surgery on hip and knee joints. Regionarnaya anesteziya i lechenie ostroy boli. 2015; 9 (4): 21–27 (in Russ.).

4. Popugaev K.A., Savin I.A., Lubnin A.Yu., Goryachev A.S., Sokolova E.Yu., Zaytsev O.S. Delirium in neurointensive care unit. Literature review. Anesteziolgiya i reanimatologiya. 2012; 4: 19–27 (in Russ.).

5. Devlin J.W., Roberts R.J., Fong J.J. et al. Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study. Crit. Care Med. 2010; 38: 419–427.

6. Fineberg S.J., Nandyala S.V., Marquez-Lara A., Oglesby M., Patel A.A., Singh K. Incidence and risk factors for postoperative delirium after lumbar spine surgery. Spine (Phila Pa 1976). 2013; 38: 1790–1796.

7. Whitlock E.L., Vannucci A., Avidan M.S. Postoperative delirium. Minerva Аnestesiologica. 2009; 41 (4): 448.93.

8. Girard T.D., Pandharipande P.P., Ely E.W. Delirium in the intensive care unit. Critical Care. 2008; 12 (3): S3.

9. Wu Y. et al. Do fluctuations in endogenous melatonin levels predict the occurrence of postoperative cognitive dysfunction (POCD). International Journal of Neuroscience. 2014; Jun.

10. Pinho C., Cruz S., Santos A., Abelha F.J. Postoperative delirium: age and low functional reserve as independent risk factors. J. Clin. Anesth. 2016; Sep. 33: 507–513. DOI: 10.1016/j.jclinane.2015.09.002.

11. O’Mahony R., Murthy L., Akunne A., Young J. Guideline Development Group. Synopsis of the National Institute for Health and Clinical Excellence guideline for prevention of delirium. Ann. Intern. Med. 2011; Jun. 7; 154 (11): 746–751.

12. Li H., Li C.D., Yi X.D., Liu H., Liu X.Y. Analysis of risk factors for delirium in the elderly patients after spinal operation. Chinese Beijing Da XueXue Bao. 2012; 44: 467–270.

13. Frontera J.A. Delirium and sedation in the ICU. Neurocrit. Care. 2011; 14: 463–474.

14. Riker R.R., Picard J.T., Fraser G.L. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit. Care Med. 1999; 19: 1317–1249.

15. Van den Boogaard M., Pickkers P., van der Hoeven H., Roodbol G., van Achteberg T., Schoonhoven L. Implementation of a delirium assessment tool in the ICU can influence haloperidol use. Crit. Care. 2009; 13 (4): R131.

16. Girard T.D., Kress J.P., Fuchs B.D. et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008; 371: 98–134.

17. Pivec R., Johnson A.J., Mears S.C., Mont M.A. Hip arthroplasty. Lancet. 2012; 380: 1768–1777.

18. Riker R.R., Shehabi Y., Bokesch P.M. et al. Dexmedetomidinevs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009; 301: 489–499.

19. Smith H.A., Boyd J., Fuchs D.C. et al. Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU). Crit. Care Med. 2009; 39: 150–157.

20. Barr J., Fraser G.L., Puntillo K. et al. Clinical practice guidelines for the management of pain, agitation and de lirium in adult patients in the intensive care unit. Crit. Care. Med. 2013; 41 (1): 263–306.

21. Patel R.P., Gambrell M., Speroff T. et al. Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1346 healthcare professionals. Crit. Care Med. 2009; 37: 427–444.

22. Pisani M.A., Murphy T.E., van Ness P.H. et al. Characteristics associated with delirium in older patients in a medical intensive care unit. Arch. Intern. Med. 2007; 167 (15): 1629–1634.

23. Kalisvaart K.J., Jonghe J.F., Bogaards M.J. et al. Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J. Am. Geriatr. Soc. 2005; 53: 1658–1666.

24. Milbrant E.B., Rersten A., Kong L. et al. Haloperidol use associated with lower hospital mortality in mechanically ventilated pacient. Crit. Care Med. 2005; 33: 226–229.

25. Wang W., Li H.L., Wang D.X. et al. Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: A randomized controlled trial. Crit. Care Med. 2012; Mar. 40 (3): 731–739.

26. Song C., Lin A., Kenis G., Bosmans E., Maes M. Immunosuppressive effects of clozapine and haloperidol: enhanced production of the interleukin-1 receptor antagonist. Schizophr. Res. 2000; 42: 157–164.

27. Bishara D., Taylor D. Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability. Drugs. 2008; 37: 189–2292.

28. Lee K.U., Won W.Y., Lee H.K. et al. Amisulpride versus quetiapine for the treatment of delirium: a randomized, open prospective study. Int. Clin. Psychopharmacol. 2005; 20: 311–314.

29. Han C.S., Kim Y.K. A double-blind trial of risperidone and haloperidol for the treatment of delirium. Psychosomatics. 2004; 45: 297–301.

30. Grover S., Kumar V., Chakrabarti S. Comparative efficacy study of haloperidol, olanzapine and risperidone in delirium. J. Psychosom. Res. 2011; 71: 277–281.

31. Girard T.D., Pandharipande P.P., Carson S.S. et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit. Care Med. 2010; 38: 420–437.

32. Zornberg G.L., Jick H. Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism: a case-control study. Lancet. 2000; 356: 1219–1223.

33. Ballard C., Hanney M.L., Theodoulou M. et al. The dementia antipsychotic withdrawal trial (DART-AD): longterm follow up on a randomised placebo-controlled trial. Lancet Neurol. 2009; 8: 151–157.

34. Ray W.A., Chung C.P., Murray K.T., Hall K,. Stein C.M. Atypical antipsychotic drugs and the risk of sudden cardiac death. N. Engl. J. Med. 2009; 360: 217–235.

35. Harrigan E.P., Miceli J.J., Anziano R. et al. A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition. J. Clin. Psychopharmacol. 2004; 24: 62–69.

36. Eijk M.M., Marum R.J., Klijn I.A. et al. Comparison of delirium assessment tools in a mixed intensive care unit. Crit. Care Med. 2009; 37 (6): 2102–2103.

37. Spronk P.E., Riekerk B., Hofhuis J., Rommes J.H. Occurrence of delirium is severely underestimated in the ICU during daily care. Intensive Care Med. 2009; 35: 996–1200.

38. Brainard J., Gobel M., Bartels K. et al. Circadian rhythms in anesthesia and critical care medicine: potential importance of circadian disruptions. Semin. Cardiothorac Vasc. Anesth. 2015; 19: 49–60.

39. Brainard J., Gobel M., Scott B. et al. Health implications of disrupted circadian rhythms and the potential for daylight as therapy. Anesthesiology. 2015; 122: 970–975. 4

40. Mistraletti G., Umbrello M., Sabbatini G. et al. Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial. Minerva Anestesiol. 2015; 42: 1298–1310.

41. Eijk M.M., Roes K.C., Honing M.L. et al. Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet. 2010; Nov. 27; 376 (9755): 1829–1837.

42. Nelson S., Muzyk A.J., Bucklin M.H. et al. Defining the role of dexmedetomidine in the prevention of delirium in the intensive care unit. Biomed. Res. Int. 2015; 2015: 635397.

43. Gregoretti C., Moglia B., Pelosi P., Navalesi P. Clonidine in perioperative medicine and intensive care unit: more than an anti-hypertensive drug. Current Drug Targets. 2009; Aug. 10 (8): 799–814.

44. Panzer O., Moitra V., Sladen R.N. Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists. Crit. Care Clin. 2009; Jul. 25 (3): 451–469.

45. Klompas M., Li L., Szumita P. et al. Associations betwen different sedatives and ventilator-associated events, length-of-stay, and mortality in mechanically ventilated patients. Chest. 2015; 149 (6): 1339–1379.

46. Michael C. Reade. Low dose dexmedetomidini for the prophylaxis of perioperative ICU delirium – how much evidence is enough? J. Thorac. Dis. 2016; 8 (11) : 3020–3023.

47. Lundstrom M., Edlund A., Karlsson S., Brannstrom B., Bucht G., Gustafson Y.A multifactorial intervention program reduces the duration of delirium, length of hospitalization, and mortality in delirious patients. J. Am. Geriatr. Soc. 2005; 53: 622–628.


Review

For citations:


Statsenko I.A., Stegalov S.V., Lebedeva M.N., Pervukhin S.A. Modern view on the problem of acute postoperative delirium in trauma and orthopedic patients in the intensive care unit. Bulletin of Siberian Medicine. 2018;17(1):211-219. (In Russ.) https://doi.org/10.20538/1682-0363-2018-1-211-219

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ISSN 1682-0363 (Print)
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