Nuclear medicine as a tool for diagnosis and targeted cancer therapy
https://doi.org/10.20538/1682-0363-2018-1-220-231
Abstract
The main trends and prospects of development of nuclear medicine, problems and possible ways of their solution are considered in the article. The main scientific directions in the development of radiopharmaceuticals for the diagnosis and radionuclide therapy of malignant tumors (radiopharmaceuticals that can accumulate in tissues surrounding the tumor; radiopharmaceuticals that can accumulate on the membranes of tumor cells, radiopharmaceuticals that can accumulate in tumor cells, radiopharmaceuticals for sentinel lymph nodes detection). It is shown that the current trends in the development of nuclear medicine are closely related to theranostics (therapy + diagnostics) using radiopharmaceuticals obtained on the basis of a target compound labeled with different isotopes intended for diagnosis or therapy. In nuclear medicine, such tandems are used to individualize and plan of radionuclide therapy. The results of our own research on the development of radiopharmaceuticals for tumor imaging and detection of sentinel lymph nodes are presented. The functional utility of radiopharmaceuticals and the prospects of their clinical use are shown.
About the Authors
V. I. Chernov
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Science (RAS) ; National Research Tomsk Polytechnic University (NR TPU).
Russian Federation
Russian Federation
Chernov Vladimir I., DM, Professor, Head of the Nuclear Medicine Department, Deputy Вirector for Scientific Work and Innovative Activities.
5, Kooperativnii Str., Tomsk, 634009; 30, Lenina Str., Tomsk, 634050.
A. A. Medvedeva
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Science (RAS).
Russian Federation
Russian Federation
Medvedeva Anna A. PhD, Senior Researcher, Nuclear Medicine Department, Cancer Research Institute.
5, Kooperativnii Str., Tomsk, 634009.
I. G. Sinilkin
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Science (RAS).
Russian Federation
Russian Federation
Sinilkin Ivan G., Senior Researcher, Nuclear Medicine Department, Cancer Research Institute.
5, Kooperativnii Str., Tomsk, 634009.
R. V. Zelchan
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Science (RAS).
Russian Federation
Russian Federation
Zelchan Roman V., PhD, Radiologist, Nuclear Medicine Department, Cancer Research Institute.
5, Kooperativnii Str., Tomsk, 634009.
O. D. Bragina
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Science (RAS).
Russian Federation
Russian Federation
Bragina Olga D., PhD, Senior Researcher, Nuclear Medicine Department, Cancer Research Institute.
5, Kooperativnii Str., Tomsk, 634009.
E. L. Choynzonov
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Science (RAS) ; National Research Tomsk Polytechnic University (NR TPU).
Russian Federation
Russian Federation
Choynzonov Evgeny L., DM, Professor, Фcademician of the RAS, Cancer Research Institute.
5, Kooperativnii Str., Tomsk, 634009; 30, Lenina Str., Tomsk, 634050.
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Review
For citations:
Chernov V.I., Medvedeva A.A., Sinilkin I.G., Zelchan R.V., Bragina O.D., Choynzonov E.L. Nuclear medicine as a tool for diagnosis and targeted cancer therapy. Bulletin of Siberian Medicine. 2018;17(1):220-231. (In Russ.) https://doi.org/10.20538/1682-0363-2018-1-220-231
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