The clinical observation of human papillomavirus positive breast tumor
https://doi.org/10.20538/1682-0363-2018-1-232-238
Abstract
In this manuscript, a unique case of HPV16-positive breast cancer is examined. The presence of HPV infection in the tumor is confirmed by two independent methods (PCR and immunohistochemistry). It is shown that in the presence of adverse factors of prognosis (lymphogenous metastasis, high level of Ki67 expression, presence of chromotrypsis in the tumor, and high level of genetic instability), a patient with a HPV-positive breast tumor has more than 8-year disease-free survival.
About the Authors
M. K. Ibragimova
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) ; National Research Tomsk State University (NR TSU).
Russian Federation
Ibragimova Marina K., Junior Researcher, Laboratory of Oncovirology, Cancer Research Institute. 5, Kooperativny Str., Tomsk, 634050; 36, Lenina Av., Tomsk, 634050.
Russian Federation
Ibragimova Marina K., Junior Researcher, Laboratory of Oncovirology, Cancer Research Institute. 5, Kooperativny Str., Tomsk, 634050; 36, Lenina Av., Tomsk, 634050.
M. M. Tsyganov
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) .
Russian Federation
Russian Federation
Tsyganov Matvey M., PhD, Junior Researcher, Laboratory of Oncovirology, Cancer Research Institute.
5, Kooperativny Str., Tomsk, 634050.
N. A. Tarabanovskaya
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) .
Russian Federation
Russian Federation
Tarabanovskaya Natalia A., PhD, Researcher, Department of General Oncology, Cancer Research Institute.
5, Kooperativny Str., Tomsk, 634050.
L. A. Tashireva
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) .
Russian Federation
Russian Federation
Tashireva Lubov A., PhD, Senior Researcher, Department of Pathological Anatomy and Cytology, Cancer Research Institute.
5, Kooperativny Str., Tomsk, 634050.
I. V. Deryusheva
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) .
Russian Federation
Russian Federation
Deryusheva Irina V., Junior Researcher, Laboratory of Oncovirology, Cancer Research Institute.
5, Kooperativny Str., Tomsk, 634050.
V. M. Perelmuter
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) .
Russian Federation
Russian Federation
Perelmuter Vladimir M., DM, Professor, Head of the Department of Pathological Anatomy and Cytology, Cancer Research Institute.
5, Kooperativny Str., Tomsk, 634050.
E. M. Slonimskaya
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS); Siberian State Medical University (SSMU).
Russian Federation
Russian Federation
Slonimskaya Elena M., DM, Professor, Head of the Department of General Oncology, Cancer Research Institute.
5, Kooperativny Str., Tomsk, 634050; 2, Moskovsky Tract, Tomsk, 634050.
N. V. Litviakov
Cancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) ; National Research Tomsk State University (NR TSU).
Russian Federation
Russian Federation
Litviakov Nikolai V., DBSc, Head of the Laboratory Oncovirology, Cancer Research Institute.
5, Kooperativny Str., Tomsk, 634050; 36, Lenina Av., Tomsk, 634050.
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Review
For citations:
Ibragimova M.K., Tsyganov M.M., Tarabanovskaya N.A., Tashireva L.A., Deryusheva I.V., Perelmuter V.M., Slonimskaya E.M., Litviakov N.V. The clinical observation of human papillomavirus positive breast tumor. Bulletin of Siberian Medicine. 2018;17(1):232-238. (In Russ.) https://doi.org/10.20538/1682-0363-2018-1-232-238
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