Health and gene polymorphisms of the hemostatic system in newborn with thrombotic and ischemic events
https://doi.org/10.20538/1682-0363-2018-2-6-12
Abstract
The purpose of this study is to reveal the peculiarities of the state, polymorphism of hemostatic genes in newborns with thrombotic and related ischemic events.
Materials and methods. The analysis of 40 fixed cards for newborns with thrombosis and isschemic events who were in the offices of GBUZ NSO “Novosibirsk State regional clinical hospital”. A study of indicators of blood coagulation, defined by the carriage of thrombohemorrhagic gene polymorphic variants was conducted. The control group included 30 healthy newborns.
Results. The structure of thrombotic complications was analyzed, and a number of ischemic complications were revealed in infants. A statistical analysis was carried out, which allowed the presence of features of hemostatic system in thrombotic and related ischemic events in newborns to be established. The most significant gene polymorphisms found with these complications in the neonatal period of life are revealed.
Conclusion. The hemostatic system in children of the considered group is characterized by a high Level of d-dimers, in the neonatal period, Leiden mutation is the most important, thrombotic and ischemic events are more common in children with a combination of several polymorphisms of the genes of the hemostasis system.
About the Authors
T. V. Belousova
Novosibirsk State Medical University (NSMU)
Russian Federation
Russian Federation
DM, Professor, Head of the Department of Pediatrics and Neonatology,
52, Krasnyi Av., Novosibirsk, 630091
A. A. Leonova
Novosibirsk State Medical University (NSMU)
Russian Federation
Russian Federation
Assistant of the Department of Pediatrics and Neonatology,
52, Krasnyi Av., Novosibirsk, 630091
V. A. Plyushkin
Novosibirsk State Medical University (NSMU)
Russian Federation
Russian Federation
PhD, Assistant of the Department of Pediatrics and Neonatology,
52, Krasnyi Av., Novosibirsk, 630091
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Review
For citations:
Belousova T.V., Leonova A.A., Plyushkin V.A. Health and gene polymorphisms of the hemostatic system in newborn with thrombotic and ischemic events. Bulletin of Siberian Medicine. 2018;17(2):6-12. (In Russ.) https://doi.org/10.20538/1682-0363-2018-2-6-12
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