Regularities in disturbances of cytological composition of synovial fluid and activity of free radical oxidative processes in case of experimental joint injury and possibility of their pathogenetic correction
https://doi.org/10.20538/1682-0363-2018-3-53-60
Abstract
The purpose of the study was to study the influence of complex peroral nimesulid administration and intraarticular etoxidol injection on lipid peroxidation processes and activity of the endogenic antioxidant system on cytological composition of synovial fluid in experimental post-traumatic arthritis.
Materials and methods. The experiments were carried out on 108 white nonlinear rats of both sexes and with a body weight of 180–200 g. The animals were divided into 4 series and excluded from the experiment on the 28th day.
Conclusion. It was established that peroral catheter nimesulid injection in combination with intra-articular etoxidol injection has a significant impact on lipid peroxidation processes, on activity of the endogenic antioxidant system and on cytological composition of synovial fluid.About the Authors
A. N. Zahvatov
National Research Ogarev Mordovia State University
Russian Federation
Russian Federation
Zahvatov Alexey N. - PhD, Associate Professor, N.I. Atyasov Department of General Surgery.
68, Bolshevistskaya Str., Saransk, 430005
A. N. Belyaev
National Research Ogarev Mordovia State University
Russian Federation
Russian Federation
Belyaev Alexander N. - DM, Professor, Chief of N.I. Atyasov Department of General Surgery.
68, Bolshevistskaya Str., Saransk, 430005
N. A. Atkina
National Research Ogarev Mordovia State University
Russian Federation
Russian Federation
Atkina Natalya A. - Student 6th year.
68, Bolshevistskaya Str., Saransk, 430005
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Review
For citations:
Zahvatov A.N., Belyaev A.N., Atkina N.A. Regularities in disturbances of cytological composition of synovial fluid and activity of free radical oxidative processes in case of experimental joint injury and possibility of their pathogenetic correction. Bulletin of Siberian Medicine. 2018;17(3):53-60. (In Russ.) https://doi.org/10.20538/1682-0363-2018-3-53-60
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