The system of tumor necrosis factor α in the pathogenesis of autoimmune diabetes mellitus
https://doi.org/10.20538/1682-0363-2011-1-64-69
Abstract
The aim of this study was to evaluate the impact of TNFα and their receptor in autoimmune diabetes. It was found the most pronounced inhibition of production of soluble forms of the receptor for TNFα in the background of an increased number of lymphocytes bearing membrane-associated receptors for TNFα in patients with manifested variant of diabetes type 1, compared to patients with latent autoimmune diabetes of adults.
About the Authors
T. S. Prokhorenko
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
T. V. Saprina
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
F. E. Lazarenko
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
N. V. Ryazantseva
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
I. N. Vorozhtsova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
V. V. Novitsky
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Кравец Е.Б., Саприна Т.В., Лазаренко Ф.Э. и др. Роль цитокинов в патогенезе аутоиммунного диабета, вопросы иммуноинтервенции//Бюл. сиб. медицины. 2010. Т. 9, № 1. С. 76-83.
2. Кричевская О.А., Клюквина Н.Г., Александрова Е.Н. и др. Фактор некроза опухоли α и его растворимые рецепторы при ревматических заболеваниях: клиническое и патогенетическое значение//Науч.-практ. ревматология. 2005. № 2. С. 43-46.
3. Саприна Т.В., Лазаренко Ф.Э., Прохоренко Т.С. и др. Особенности базальной и стимулированной секреции интерлейкинов-2 и -4 мононуклеарами крови при аутоиммунном диабете//Сиб. мед. журн. 2010. Т. 25, № 1. С. 41-44.
4. Смирнова О.М., Кононенко И.В., Дедов И.И. Аутоиммунный латентный сахарный диабет у взрослых//Проблемы эндокринологии. 2008. Т. 54, № 2. С. 1-7.
5. Atkinson M.A., Gianani R. The pancreas in human type 1 diabetes: providing new answers to age-old questions//Curr. Opin. Endocrinol. Diabetes Obes. 2009. V. 16, № 4. P. 279-285.
6. Ban L., Zhang J., Wang L. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism//The National Acad. of Scien. 2008. V. 105, № 36. P. 13644-13649.
7. Ben-Mahmud B.M., Chan W.H., Abdulahad R.M. et al. Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy//Diabetologia. 2006. V. 49, № 9. P. 2185-2191.
8. Ben-Mahmud B.M., Mann G.E., Datti A. et al. Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial sells: significance of core 2 GlcNAc-T in diabetic retinopathy//Diabetes. 2004. V. 53, № 11. P. 2968-2976.
9. Bruun C., Heding P.E., Ronn S.G. et al. Inhibitory effects of suppressor of cytokine signalling-3 on tumor necrosis factor-alpha induced signalling in pancreatic beta cells//Diabetologia. 2005. V. 48. P. 181-188.
10. Bruun C., Heding P.E., Ronn S.G http://www.ncbi.nlm.nih.gov/pubmed?term=%22R%C3%B8nn%20SG%22%5BAuthor%5D . Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells // Mol. Cell. Endocrinol. 2009. № 13. P. 32-38.
11. Chan F.K. The pre-ligand binding assemble domain: a potential target of inhibition of tumour necrosis factor receptor function//Ann. Rheun. Dis. 2000. V. 59. P. 150-153.
12. Doganay S., Evereklioglu C., Er H. et al. Comrarison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patiens with diabetes mellitus//Eye. 2002. V. 16, № 2. P. 163-170.
13. Fourlanos S., Perry C., Stein M.S. et al. A clinical screening tool identifies autoimmune diabetes in adults//Diabetes Care. 2006. V. 29, № 5. P. 970-975.
14. Hohmeier H.E., Tran W., Chen G. et al. Inflammatory mechanisms in diabetes: lessons from the β-cell//Int. J. Obesity. 2003. V. 27. P. 12-16.
15. Hussain M.J., Maher J., Warnock T. et al. Cytokine overproduction in healthy first degree relatives of patients with IDDM//Diabetologia. 1998. V. 41, N 3. P. 343-349.
16. Hussain M.J., Peakman M., Gallati H. et al. Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM//Diabetologia. 1996. V. 39, № 1. P. 60-69.
17. Ihnatko R., Kubes M. TNF signaling: early events and phosphorylation//Gen. Physiol. Biophys. 2007. V. 26, № 3. P. 159-167.
18. Locksley R.M., Killeen N., Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology//Cell. 2001. V. 104. P. 487-501.
19. MacEwan D.J. TNF ligand and receptors -a matter of life and death//British Jour. Of Pharm. 2002. V. 135. P. 855-875.
20. Maioli M., Puddu L., Pes G. M. et al. Latent autoimmune diabetes in adults (Article in Italian)//Clin. Ter. 2006. V. 157, № 1. P. 69-78
21. Margolles-Clark E., Kenyon N.S., Ricordi C. et al. Effective and Specific Inhibition of the CD40-CD154 Costimulatory Interaction by a Naphthalenesulphonic Acid Derivative//Chem. Biol. Drug. Des. 2010. V. 52, № 3. P. 372-386.
22. Ortis F., Pirot P., Naamane N. et al. Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells//Diabetologia. 2008. V. 51, № 7. P. 1213-1225.
23. Ortis F., Naamane N., Flamez D. et al. Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells//Diabetes. 2010. V. 59, № 2. P. 358-374.
24. Rabinovitch A., Suarez-Pinzon W.L. Roles of cytokines in the pathogenesis and therapy of type 1 diabetes//Cell Biochem Biophys. 2007. V. 482, № 3. P. 159-163.
25. Schneider-Brachert W., Tchikov V., Neumeyer J. et al. Compartmentalization of TNF receptor 1 signaling; internalized TNF receptosomes as death vesicles//J. Immunity. 2004. V. 21, № 3. P. 415-428.
26. Schütze S., Tchikov V., Schneider-Brachert W. Regulation of TNFR1 and CD95 signalling by receptor compartmentalization//Nat. Rev. Mol. Cell. Biol. 2008. V. 9, № 8. P. 655-662.
27. Suarez-Pinzon W., Sorensen O., Bleackley R.C. et al. Beta-cell clestruction in NOD mice correlate with Fas (CD 95) expression on beta-cell and proinflammation cytokine expression in islets//Diabetologia. 1999. V. 48, № 1. P. 21-28.
28. Uno S., Imagawa A., Okita K. et al. Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recen-tonset type 1 diabetes//Diabetologia. 2007. V. 50, № 3. P. 596-601.
29. Wajant H., Pfizenmaier K., Scheurich P. Tumor necrosis factor signaling//Cell. Death. Differ. 2003. V. 10. P. 45-65.
Review
For citations:
Prokhorenko T.S., Saprina T.V., Lazarenko F.E., Ryazantseva N.V., Vorozhtsova I.N., Novitsky V.V. The system of tumor necrosis factor α in the pathogenesis of autoimmune diabetes mellitus. Bulletin of Siberian Medicine. 2011;10(1):64-69. (In Russ.) https://doi.org/10.20538/1682-0363-2011-1-64-69
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