Молекулярные аспекты функционирования T-хелперов 17-го типа
https://doi.org/10.20538/1682-0363-2011-4-93-98
Аннотация
Представлены современные научные данные о функционировании Т-хелперов 17-го типа (Th17). Описывается история открытия Th17, транскрипционные факторы, а также механизмы, опосредующие стимуляцию и ингибирование дифференцировки Th17. Перечислены цитокины, продуцируемые данной лимфоцитарной субпопуляцией, и сигнальные пути, за счет которых реализуются их эффекты. Дается краткое описание физиологических процессов и заболеваний, в развитии которых доказано участие Th17.
Об авторах
И. В. Кологривова
НИИ кардиологии СО РАМН
Россия
Россия
Кологривова Ирина Вячеславовна, науч. сотрудник отделения функциональной и лабораторной диагностики
тел.: 8 (3822) 55-83-85; 8-913-105-3869
Е. Н. Кологривова
Сибирский государственный медицинский университет
Россия
д-р мед. наук, профессор кафедры иммунологии и аллергологии
Россия
д-р мед. наук, профессор кафедры иммунологии и аллергологии
Т. Е. Суслова
НИИ кардиологии СО РАМН
Россия
канд. мед. наук, вед. науч. сотрудник отделения функциональной и лабораторной диагностики
Россия
канд. мед. наук, вед. науч. сотрудник отделения функциональной и лабораторной диагностики
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Рецензия
Для цитирования:
Кологривова И.В., Кологривова Е.Н., Суслова Т.Е. Молекулярные аспекты функционирования T-хелперов 17-го типа. Бюллетень сибирской медицины. 2011;10(4):93-98. https://doi.org/10.20538/1682-0363-2011-4-93-98
For citation:
Kologrivova I.V., Kologrivova Ye.N., Suslova T.Ye. Molecular aspects of the T-helpers type 17 functioning. Bulletin of Siberian Medicine. 2011;10(4):93-98. (In Russ.) https://doi.org/10.20538/1682-0363-2011-4-93-98
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