The investigation of acute toxicity of water-soluble polysaccharides extracted from calamus root (Acorus calamus L.)
https://doi.org/10.20538/1682-0363-2010-1-36-39
Abstract
An investigation for a possible acute toxicity of the complex of water-soluble polysaccharides (WSPS) extracted from calamus root (Acorus calamus L.) has been performed. No toxic effect has been observed on the organisms of experimental animals after a twofold intragastric, subcutaneous, and intravenous introduction of the highest maximum dose of the WSPS being investigated. The results of the experiments did not allow detecting the average fatal dose (LD50) of the WSPS being investigated as no deaths among the experimental animals had been observed. The obtained data lead to the conclusion that the WSPS of calamus root are to be added to Substance Hazard Class IV (low hazard substances) in compliance with State Standard GOST 12.1.007-76.
About the Authors
A. M. Guriyev
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. V. Belousov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. S. Yusubov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
R. R. Akhmedzhanov
Томский политехнический университет
Russian Federation
Russian Federation
Ye. P. Zuyeva
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
K. A. Lopatina
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Guriyev A.M., Belousov M.V., Yusubov M.S., Akhmedzhanov R.R., Zuyeva Ye.P., Lopatina K.A. The investigation of acute toxicity of water-soluble polysaccharides extracted from calamus root (Acorus calamus L.). Bulletin of Siberian Medicine. 2010;9(1):36-39. (In Russ.) https://doi.org/10.20538/1682-0363-2010-1-36-39
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