The abatement of local mucosal immunity as the factor of nasal polyposis recidivation
https://doi.org/10.20538/1682-0363-2010-5-60-63
Abstract
Assessment of the role of mucosal immunity in nasal polyposis recidivation was carried out. The density and the composition of inflammatory infiltrate in polyps from the patients with the primary and the recurrent nasal polyposis were researched. In nasal lavage the composition of the cells and the content of interleukin-4 and interferon-γ were estimated. It was shown that the polyposis recidivation occurs during the progression of local immune insufficiency.
About the Authors
Ye. N. KologrivovaRussian Federation
A. V. Starokha
Russian Federation
R. I. Pleshko
Russian Federation
P. Yu. Isayev
Russian Federation
M. A. Kovalyova
Russian Federation
References
1. Бондарева Г.П. Полипозный ринит//Consilium medicum. 2000. Т. 2, № 8. С. 344-345
2. Ильинская Е.В., Захарова Г.П. Морфофункциональные особенности собственного слоя слизистой оболочки верхнечелюстных пазух при хроническом полипозном и полипозно-гнойном риносинусите//Рос. ринология. 2002. № 1. С. 11-14
3. Карсонова М.И., Пинегин Б.В. Лимфоидные образования слизистых оболочек: принципы топической иммунизации//Иммунология. 2003. № 6. С. 359-365
4. К вопросу о патогенезе и морфогенезе антрохоанальных полипов//Рос. ринология. 1997. № 3. С. 22-27
5. Лазарева А.Ю. Полипозный риносинусит у лиц пожилого возраста и варианты их реабилитации//Рос. ринология. 2006. № 1. С. 122-124
6. Лопатин А.С. Медикаментозное лечение полипозного риносинусита//Consilium Medicum. 2002. Т. 4, № 9. С. 531-536
7. Матвеева Л.А. Местный иммунитет при болезнях легких у детей. Томск: Изд-во Том. ун-та, 1986. 192 с
8. Kay A.B., Phipps S., Robinson D.S. et al. A role of eosinophils in airway remodeling in asthma//Trends Immunol. 2004. 25. 477-482
9. Pitzurra L., Bellocchio S., Nocentini A. et al. Antifungal immune reactivity in nasal polyposis//Infection and Immunity. 2004. V. 72, № 12. P. 7275-7281
10. Minshal E.M., Leung D.Y., Martin R.Y. et al. Eosinophil-associated TGF-betal mRNA expression and airways fibrosis in bronchial asthma//Am. J. Respir. Cell Mol. Biol. 1997. V. 17. P. 326-333
11. Gosepath J., Hoffmann F., Schraefer D. et al. Aspirin tolerance in patients with chronic sinusitis//ORL. 1999. V. 61. P. 146-150
12. Liu C.-M., Shun C.-T., Hsu M.-M. Lymphocyte subsets and antigen-specific IgE antibody in nasal polyps//Ann. Allergy. 1994. V. 72. P. 19-24
13. Zuercher A.W., Coffiin S.E., Thurnheer M.C. et al. Nasal-associated lymphoid tissue a mucosal inductive site for virus-specific humoral and cellular immune responses//J. Immunol. 2002. V. 168. P. 1796-1803
Review
For citations:
Kologrivova Ye.N., Starokha A.V., Pleshko R.I., Isayev P.Yu., Kovalyova M.A. The abatement of local mucosal immunity as the factor of nasal polyposis recidivation. Bulletin of Siberian Medicine. 2010;9(5):60-63. (In Russ.) https://doi.org/10.20538/1682-0363-2010-5-60-63