The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients
https://doi.org/10.20538/1682-0363-2009-3-74-78
Abstract
We evaluated some biochemical and immune parameters, such as IgA, IgM, IgG, CIC, phagocytic index, T-lymphocytes, as well as avidity of antibodies in type 2 diabetic patients.
Avidity, high- and low-avid antibody ratio was determined by test-systems for express-diagnostics of clinical and preclinical forms of immunologic deficiency. All patients (n = 47), depending on the level of glycemia and disease duration were divided into 3 groups: in the stage of compensation, subcompensation and decompensation. Control group included 17 healthy subjects.
Value of high-avid antibodies in diabetes mellitus patients decreased in 75, 57 and 26% respectively, whereas in healthy subjects it is 89%. Conversely, increased amount of low-avid antibodies was observed, respectively 25, 43, and 74% (11% in control).
These parameters prove antibody-folding disorders in diabetes mellitus and show that, change of metabolic parameters affects antibody avidity: G class high-avid antibody level decreases and shows weak protective function. This indicates functional disorders in B-system immunity.
About the Authors
A. M. Efendiyev
Азербайджанский медицинский университет
Azerbaijan
Azerbaijan
G. I. Azizova
Азербайджанский медицинский университет
Azerbaijan
Azerbaijan
G. R. Huseynova
Азербайджанский медицинский университет
Azerbaijan
Azerbaijan
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Review
For citations:
Efendiyev A.M., Azizova G.I., Huseynova G.R. The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients. Bulletin of Siberian Medicine. 2009;8(3):74-78. (In Russ.) https://doi.org/10.20538/1682-0363-2009-3-74-78
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