Functional significance of polymorphism of ApoE and SOD2 genes in formation of chronic HCV infection
https://doi.org/10.20538/1682-0363-2009-3-64-68
Abstract
The analysis of gene polymorphism plays an important role in assessment of disposition to infectious diseases at the population and individual level. In this paper, the frequencies of allelic versions of apolipoprotein E and 2nd type superoxide dismutase genes and the corresponding genotypes were determined in healthy persons and chronic viral hepatitis type C patients of the Europeoid population of the Tomsk Region. For the analysis of polymorphism of these genes, we used modern genetic methods: polymerase chain reaction and polymorphism of lengths of restriction fragments. For the studied population, it was revealed that the polymorphism of apolipoprotein E and 2nd type superoxide dismutase genes correlates with the development of chronic viral hepatitis type C and with the fibrogenesis process.
About the Authors
N. A. Semyonova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
N. V. Ryazantseva
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
V. V. Novitsky
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
A. I. Dmitriyeva
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
O. Ye. Chechina
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
V. A. Bychkov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
I. P. Moiseyenko
Клиническая больница № 81 Федерального медико-биологического агентства
Russian Federation
Russian Federation
References
1. Коровайцева Г.И., Щербатых Т.В., Селезнёва Н.В. и др. Генетическая ассоциация между аллелями гена аполипопротеина Е и различными формами болезни Альцгеймера//Генетика. 2001. Т. 37, № 4. С. 529-535.
2. Логинов А.С., Матюшин Б.Н., Чебанов С.М., Решетняк В.И. Оценка холестаза по активности антиоксидантных ферментов и составу липопротеинов плазмы крови больных с патологией печени//Терапевт. арх. 1998. № 4. С. 40-42.
3. Нагоев Б.С., Иванова М.Р. Роль системы антиоксидантной защиты организма в патогенезе острых вирусных гепатитов//Терапевт. арх. 2003. № 11. С. 15-17.
4. Andre P., Komurian&Pradel F., Deforges S. et al. Characterization of low-and very-low-density hepatitis C virus RNA-containing particles//J. Virol. 2002. V. 76. P. 6919-6928.
5. Bedossa P., Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group//Hepatology. 1996. V. 24289-24293.
6. Elchuri S., Oberley T.D., Qi W. et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life//Oncogene. 2005. V. 24, № 3. P. 367-80.
7. Ergen H.A., Narter F., Timirci O., Isbir T. Effects of manganase superoxide dismutase Ala-9Val polymorphism on prostate cancer: a case-control study//Anticancer Res. 2007. V. 27, № 2. P. 1227-1230.
8. Huang H., Sun F., Owen D.M. et al. Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins//PNAS. 2007. V. 104, № 14. P. 5848-5853.
9. Sazci A., Akpinar G., Aygun C. et al. Association of Apolipoprotein E Polymorphisms in Patients with Non-Alcoholic Steatohepatitis//Dig. Dis. Sci. 2008. V. 53. P. 218-224.
10. Sobkowiak A., Lianeri M., Wudarski M. et al. Manganese superoxide dismutase Ala-9Val mitochondrial targeting sequence polymorphism in systemic lupus erythematosus in Poland//Clin. Rheumatol. 2008. V. 27. P. 827-831.
Review
For citations:
Semyonova N.A., Ryazantseva N.V., Novitsky V.V., Dmitriyeva A.I., Chechina O.Ye., Bychkov V.A., Moiseyenko I.P. Functional significance of polymorphism of ApoE and SOD2 genes in formation of chronic HCV infection. Bulletin of Siberian Medicine. 2009;8(3):64-68. (In Russ.) https://doi.org/10.20538/1682-0363-2009-3-64-68
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