The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons
https://doi.org/10.20538/1682-0363-2009-3(2)-49-54
Abstract
Alleles frequencies and polymorphisms genotypes frequencies of gene DRD4 (VNTR), gene DAT (VNTR), gene 5-HTT (VNTR and ID) and gene OPRM1 (SNP) were investigated at Russian males taking narcotic substances. It was determined that genotype 4/3 occurs only at persons taking narcotic substances, the most often occurring polymorphism of gene DRD4 is genotype 4/4 in all groups. It was detected that the polymorphism of gene DAT at narcotized persons is presented by the high enough part of genotypes 9/10 and 10/10, but in the rest of groups the distribution is the same. At narcotized persons and in the control group, the carriers’ part of genotype I/D of gene 5НТ2А is high. The genotype D/D occurs only at persons taking narcotic substances. The genotype10/10 of gene 5НТ2А occurs more often than in population group, which conforms to the literature data.
About the Authors
Ye. V. Сherepkova
Научный центр клинической и экспериментальной медицины СО РАМН
Russian Federation
Russian Federation
I. A. Gribacheva
Новосибирский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Сherepkova Ye.V., Gribacheva I.A. The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons. Bulletin of Siberian Medicine. 2009;8(3(2)):49-54. (In Russ.) https://doi.org/10.20538/1682-0363-2009-3(2)-49-54
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