THE RISK FOR DEVELOPING TUMOR IN PATIENTS WITH GONADAL DYSGENESIS 46,XY
https://doi.org/10.20538/1682-0363-2015-5-41-46
Abstract
Disorders of sex development with Y chromosome material has been associated with a high risk for developing germ cell tumors such as gonadoblastoma or dysgerminoma. The aim of the study was to investigate the risk of germ cell tumors in patients with XY gonadal dysgenesis. Material and methods. In the study included 11 patients with XY gonadal dysgenesis: 4 with complete gonadal dysgenesis and 4 with partial gonadal dysgenesis. Results. Pathologic examination revealed gonadoblastoma and dysgerminoma with gonadoblastoma in 2 of 9 (22%) patients (who had gonadectomy), including 2 of 3 patients (66 %) with complete gonadal dysgenesis. In our series of patients with gonadal dysgenesis 46,XY the risk of germ cell tumors was high, especially in patients with complete gonadal dysgenesis. Considering this results, early gonadectomy is strongly recommended in females patients. The patients with partial dysgenesis with scrotal gonads being reared as males need monitoring.
About the Authors
O. Yu. Latyshev
Medical Academy of Postgraduate Education Study, Moscow
Russian Federation
Latyshev Oleg Yu.
Russian Federation
Latyshev Oleg Yu.
L. N. Samsonova
Medical Academy of Postgraduate Education Study, Moscow
Russian Federation
Samsonova Lyubov N.
Russian Federation
Samsonova Lyubov N.
E. P. Kasatkina
Medical Academy of Postgraduate Education Study, Moscow
Russian Federation
Kasatkina Elvira P.
Russian Federation
Kasatkina Elvira P.
G. F. Okminyan
Medical Academy of Postgraduate Education Study, Moscow
Russian Federation
Okminyan Goar F.
Russian Federation
Okminyan Goar F.
Ye. V. Kiselyova
Medical Academy of Postgraduate Education Study, Moscow
Russian Federation
Kiselyova Yelena V.
Russian Federation
Kiselyova Yelena V.
Ye. S. Timofeyeva
Medical Academy of Postgraduate Education Study, Moscow
Russian Federation
Timofeyeva Yekaterina S.
Russian Federation
Timofeyeva Yekaterina S.
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Review
For citations:
Latyshev O.Yu., Samsonova L.N., Kasatkina E.P., Okminyan G.F., Kiselyova Ye.V., Timofeyeva Ye.S. THE RISK FOR DEVELOPING TUMOR IN PATIENTS WITH GONADAL DYSGENESIS 46,XY. Bulletin of Siberian Medicine. 2015;14(5):41-46. (In Russ.) https://doi.org/10.20538/1682-0363-2015-5-41-46
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