The features of pathophisiology Helicobacter pilory associated ulceractive disease from the Khakasses
https://doi.org/10.20538/1682-0363-2009-4-5-9
Abstract
Peculiarities of pathogene sis of Helicobacter pylori (HP)-associated gastric ulcer (GU) in Khakas se s are investigated. It is found that, in con - trast to Caucasian s, the activation of the Т-cell and humoral parts of the immune response in Mongoloids with GU is accompanied by the high con - tent of CD4 +- and CD20 +-lympho cytes in the muscou s coat of stomach. Changes revealed in the peripheral blood in GU patients were character - ized by a decrease in the magnitude of CD4 +- and CD8 +-lympho cyte subpopulations compared to patients with chronic gastritis. The detected pos - itive correlation between the АА-251 genotype of interleukin-8 and the risk of GU development in Khakssses indicated in favor of the existence of immuno-genetic regularities of GU development. The reasonability of determining population risk and protective genotypes of development of HРassociated GU in Khakasses is discussed.
About the Authors
Ye. S. Ageyeva
Хакасский государственный университет им. Н.Ф. Катанова
Russian Federation
Russian Federation
O. V. Shtygasheva
Хакасский государственный университет им. Н.Ф. Катанова;
ГУЗ «Хакасская республиканская больница им. Г.Я. Ремишевской»
Russian Federation
Russian Federation
N. V. Ryazntseva
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Александрова В.А., Козлова И.П. Спорные и нерешенные вопросы хеликобактерной инфекции у детей//Лечащий врач. 2002. № 11. С. 13-16.
2. Аруин Л.И., Григорьев П.Я., Яковенко Э.П. Хронический гастрит. Амстердам, 1993. 362 с.
3. Баранская Е.К. Язвенная болезнь и инфекция НР//Рус. мед. журн. 2000. Т. 2, № 1. С. 48-53.
4. Козлова Н.Н., Прокопенко В.Д. Иммунный ответ при инфекции Helicobacter pylori//Иммунопатология, аллергология, инфектология. 2007. № 4. С. 58-62.
5. Новикова А.В., Газизова P.P., Шершевская А.Я., Лобанов Ю.Ф. и др. Возрастные характеристики иммунных реакций при хроническом гастрите//Арх. патологии. 1995. Т. 57, № 12. С. 61-64.
6. Останин А.А., Пальцев А.И., Лебедев А.Г. и др. Характеристика апоптотической и функциональной активности лимфоцитов у больных язвенной болезнью//Бюл. СО РАМН. 2004. № 1 (111). С. 129-134.
7. Сельчук В.Ю., Никулин М.П. Рак желудка//Российский онкологический научный центр им. Н.Н. Блохина РАМН. 2005. www.neuch.ru.
8. Цуканов В.В., Баркалов С.В., Тонких Ю.А. и др. Распространенность CagA-штаммов Helicobacter pylori и язвенная болезнь у населения Восточной Сибири//Терапевт. арх. 2007. № 2. С. 15-18.
9. Allen R.T., Hunter W.J., Agrawal D.K. Morphological and Biochemical Characterization and Analysis of Apoptosis//Journal of Pharmacological and Toxicological Methods. 1997. V. 37, № 4. P. 215-228.
10. Camorlinga-Ponce M., Torres J., Perez-Perez J. et al. Validation of a serological test for the diagnosis of Helicobacter pylori infection and the immune response to urease and CagA in children//Amer. J. Gastroent. 1998. № 93. P. 1264-1270.
11. Correa P. HP as a pathogen and carcinogen//J. Physiol. Pharmacol. 1997. V. 48. Suppl. 4. P. 19-24.
12. Cover T.L., Berg D.E., Blaser M.J. VacA and the CagA pathogenicity of H. pylori//The immunobiology of H. pylori: from pathogenesis to prevention. Lippincott-Raven Publishers, Philadelphia, New York, 1997. P. 75-90.
13. D'Elios M.M., Manghetti M., De Carli M. et al. T helper 1 effectors cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease//J. Immunol. 1997. V. 158. P. 962-967.
14. Goll R., Husebekky A., Isaksenz V. et al. Increased frequency of antral CD4+ T and CD19+ B Cells in patients with Helicobacter pylori-related peptic ulcer disease//Blackwell Publishing Ltd. Scandinavian Journal of Immunology. 2005. V. 61. P. 92-97.
15. Itoh T., Wakatsuki Y., Yoshida M. et al. The vast majority of gastric T cells are polarized to produce T helper 1 type cytokines upon antigenic stimulation despite the absence of Helicobacter pylori infection//J. Gastroenterol. 1999. V. 34. P. 560-570.
16. Landi S., Moreno V., Gioia-Patricola L. et al. Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor-α, NF-κB1, and peroxisome proliferator-activated receptor γ with colorectal cancer//Cancer Res. 2003. V. 63. P. 3560-3566.
17. Lohoff M., Rollinghoff M., Sommer F. Helicobacter pylori gastritis: a Th1 mediated disease?//J. Biotechnol. 2000. V. 83. P. 33-36.
18. Luzza F., Parrello T., Sebkova L. et al. Expression of proinflammatory and Th1 but not Th2 cytokines is enhanced in gastric mucosa of Helicobacter pylori infected children//Dig Liver Dis. 2001. V. 33. P. 14-20.
19. McCarron S.L., Edwards S., Evans P.R. et al. Influence of cytokine gene polymorphisms on the development of prostate cancer//Cancer Res. 2002. V. 62. P. 3369-3372.
20. Meyer F., Wilson K.T., James S.P. Modulation of innate cytokine responses by products of Helicobacter pylori//Infect. Immunol. 2000. V. 68. P. 6265-6272.
21. Rigler R.J. Microfluorometric characterization of intracellular nucleic acids and nucleoproteins by acridine orange//Acta Physiologica Scandinavica (Suppl). 1996. V. 267. P. 1-122.
Review
For citations:
Ageyeva Ye.S., Shtygasheva O.V., Ryazntseva N.V. The features of pathophisiology Helicobacter pilory associated ulceractive disease from the Khakasses. Bulletin of Siberian Medicine. 2009;8(4):5-9. (In Russ.) https://doi.org/10.20538/1682-0363-2009-4-5-9
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