The study of the Crataegus sanguinea Pall. extractsdiuretic and antidepressant action
V. A. Kurkin,
E. N. Zaitceva,
T. V. Morozova,
O. E. Pravdivtseva,
A. V. Dubishchev,
A. V. Kurkina,
E. V. Avdeeva,
A. I. Agapov,
M. V. Belousov https://doi.org/10.20538/1682-0363-2018-4-65-71
Abstract
The purpose of the study is to study the urinative and antidepressant activities of liquid extracts based on flowers, shoots, leaves and fruits of Crataegus sanguinea Pall. to substantiate their use in the development and manufacture of drugs for the complex treatment of cardiovascular diseases.
Materials and methods. The comparative study of the diuretic and antidepressant activity of liquid extracts based on leaves, flowers, shoots and fruits Crataegus sanguinea was conducted. The liquid extracts were obtained on the basis of dried leaves, flowers, shoots and fruits of Crataegus sanguinea. All liquid extracts were obtained in the ratio “raw – extractant” 1 : 1, in all cases the extracting agent was ethyl alcohol 70%. The studies were conducted using outbred white rats of both sexes. All preparations were examined in a dose of 100 μl/kg. The diuretic activity of Crataegus sanguineaof liquid extracts in chronic experiments was determined, 4 h and 24 h portions of urine were collected. The antidepressant activity was tested using the “Desperation” test
Results. During the experiment, the diuretic activity of the liquid extract Crataegus sanguinea, as well as the antidepressant activity of liquid extracts of Crataegus sanguinea, shoots and fruits were revealed. Conclusion. Crataegus sanguinea preparations have complex nephrotropic and neurotropic action and can be recommended for use in the cardiovascular pathology treatment.
About the Authors
V. A. Kurkin
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Kurkin Vladimir A., DPhSc, Professor, Head of Pharmacognosy with Botany and Phytotherapy Department
89, Chapaevskaya Str., Samara, 443099
E. N. Zaitceva
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Zaitceva Elena N., DM, Associate Professor, Head of the Pharmacology Department
89, Chapaevskaya Str., Samara, 443099
T. V. Morozova
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Morozova Tatiana V., Postgraduate Student, Pharmacognosy with Botany and Basis of Phytotherapy Department
89, Chapaevskaya Str., Samara, 443099
O. E. Pravdivtseva
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Pravdivtseva Olga E., DPhSc, Associate, Pharmacognosy with Botany and Basis of Phytotherapy Department
89, Chapaevskaya Str., Samara, 443099
A. V. Dubishchev
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Dubishchev Alexey V., DM, Professor, Pharmacology Department
89, Chapaevskaya Str., Samara, 443099
A. V. Kurkina
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Kurkina Anna V., DPhSc, Associate Professor, Pharmacognosy with Botany and Basis of Phytotherapy Department
89, Chapaevskaya Str., Samara, 443099
E. V. Avdeeva
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Avdeeva Elena V., DPhSc, Professor, Pharmacognosy with Botany and Basis of Phytotherapy Department
89, Chapaevskaya Str., Samara, 443099
A. I. Agapov
Samara State Medical University (SamSMU)
Russian Federation
Russian Federation
Agapov Albert I., DPhSc, Professor, General Bioinorganic and Bioorganic Chemistry Department
89, Chapaevskaya Str., Samara, 443099
M. V. Belousov
Siberian State Medical University (SSMU)
Russian Federation
Russian Federation
Belousov Michail V., DPhSc, Professor, Head of the Department of Pharmaceutical Analysis
2, Moscow Tract, 634055
References
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Review
For citations:
Kurkin V.A., Zaitceva E.N., Morozova T.V., Pravdivtseva O.E., Dubishchev A.V., Kurkina A.V., Avdeeva E.V., Agapov A.I., Belousov M.V. The study of the Crataegus sanguinea Pall. extractsdiuretic and antidepressant action. Bulletin of Siberian Medicine. 2018;17(4):65-71. (In Russ.) https://doi.org/10.20538/1682-0363-2018-4-65-71
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