EXPERIMENTAL SUBSTANTIATION OF APPLICATION IMMOBILIZED FORM CHLORHEXIDINEBIGLUCONATE IN TREATMENT OF PURULENT WOUNDS

Introduction. One of the important problems of modern surgery is the local drug treatment of inflamma-tory processes of soft tissues, which is associated with a high prevalence of this disease, the desensitization of microorganisms to antibiotics.

Objectives. Prove experimentally the possibility of using chlorhexidine bigluconate immobilized form in the treatment of purulent wounds.

Methods. The analysis of the results of experimental studies of wound healing process on 180 Wistar rats line in the treatment of the following composition of ointment: chlorhexidine bigluconate 0.5% – 30.0; methyluracil – 2.0; polymethylsiloxane polyhydrate – 70.0. Animals were divided into 3 statistically ho mogeneous groups of 60 animals each. In the series comparison, local wound treatment was carried out using the ointment «Levomecol» (chloramphenicol + metiluratsil), while in the series pilot – using an immobilized form of chlorhexidine bigluconate, a control series of no treatment.

Results. Percentage reduction in the series pilot area of the wounds was higher than in the series comparison on day 10 to 12.8%, on day 15 to 11.1%. In the series pilot of animals microbial contamination of wounds (CFU in1 g of tissue) was lower than in the wounds of the series comparison on the 5th day – on 4,3 ∙ 105 and on the 10th day –62,5 ∙ 103. At the same period, the number of fibroblasts in the wounds of the series pilot was more by 10.6 and 9.4%.

Conclusion. The use of an immobilized forms of chlorhexidine bigluconate in the treatment of the first phase of purulent wounds pathogenetically justified and effective. 

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