Assessment of indicators of medical and biological monitoring of iodine deficiency diseases
https://doi.org/10.20538/1682-0363-2019-1-96-108
Abstract
The problem of iodine deficiency remains relevant all over the world due to the widespread prevalence and the negative impact it has on human health in all agegroups. Iodine deficiency leads to a decrease in the intellectual potential of children, the development of reproductive disorders at a young age, as well as the formation of multinodular toxic goiter as the last stage of goiter transformation, accompanied by heart rhythm disturbances in middle and old age. The article covers the issues of monitoring iodine deficiency in the regions of Russia and provides data on the situation in the world on the development of future prevention programs and current prevention programs. A detailed analysis of each criterion for the severity of iodine deficiency and the effectiveness of preventive programs was carried out. Particular attention is paid to the criterion of neonatal hyperthyrotropinemia as a promising indicator for monitoring iodine deficiency.
About the Authors
L. A. Suplotova
Tyumen State Medical University
Russian Federation
Russian Federation
Suplotova Ludmila А., DM, Рrofessor, Нead of the Тhеrapy Department, Tyumen State Medical University, Head endocrinologist of the Tyumen region
54, Odesskaya Str., Tyumen, 625023
O. B. Makarova
Tyumen State Medical University
Russian Federation
Russian Federation
Makarova Olga В., PhD, Аssistant Рrofessor, Тhеrapy Department
54, Odesskaya Str., Tyumen, 625023
L. S. Kovalzhina
Industrial University of Tyumen
Russian Federation
Russian Federation
Kovalzhina Larisa S., PhD, Аssistant Рrofessor, Management in the Sectors of Energy
38, Volodarskogo Str., Tyumen, 625000
G. V. Sharuho
Tyumen State Medical University;
Federal Service for Supervision of Consumer Rights and Human Welfare in the Tyumen Region
Russian Federation
Russian Federation
Sharuho Galina V., DM, Head of the Federal Service for Supervision of Consumer Rights and Human Welfare in the Tyumen region
54, Odesskaya Str., Tyumen, 625023,
45А, Righskaya Str., Tyumen 625026
References
1. Gerasimov G.A., Fadeev V.V., Sviridenko N.Ju., Mel'nichenko G.A., Dedov I.I. Iodine deficiency disorders in Russia. A simple solution to a complex problem. Мoscow: Adamant Publ., 2002: 168 (in Russ.)
2. Platonova N.M. Iodine deficiency: the current state of the problem. Clinical and Еxperimental Тhyroidology. 2015; 11 (1): 12–21 (in Russ.). DOI: 10.14341/ket2015112-21.
3. UNICEF. World declaration on the survival, protection and development of children the World Summit for Children. New York: UNICEF, 1990.
4. World Health Organization. Overcoming iodine deficiency disoders. Geneva (Switzland): WHO, 1990.
5. World Health Organization/UNICEF/International Council for the Control of Iodine Deficiency Disorders. Global prevalence of iodine deficiency disorders. Micronutrient Deficiency Information System Working Paper No. 1. Geneva: WHO, 1993.
6. Zimmermann M.B., Jooste P.L, Pandav C.S. Iodinedeficiency disorders. Lancet. 2008; 372 (9645): 1251–1262. DOI: 10.1016/S0140-6736(08)61005-3.
7. Zimmermann M.B. Iodine deficiency. Endocr. Rev. 2009; 30: 376–408. DOI: 10.1210/er.2009-0011.
8. Zimmermann M.B., Andersson M. Assessment of iodine nutrition in populations: past, present, and future. Nutr. Rev. 2012; 70: 553–70. DOI: 10.1111/j.1753-4887.2012.00528.x
9. Troshina E.A., Platonova N.M., Solov'eva S.I., Abdulhabirova F.M. Intellectual development of school children with diffuse clinically euthyroid goiter in regions with different iodine security. Pediatric Pharmacology. 2009; 6 (2): 43–48 (in Russ.)
10. Shhepljagina L.A., Makulova N.D., Maslova O.I. Scientific Center of Children's Health, RAMS, Moscow. The state of the cognitive sphere in children in areas with iodine deficiency. Consilium Medicum. 2001; 08 (in Russ.).
11. Angela M. Leung, Gregory A. Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8–9 years of age. Evidence-based Nursing. 2014; 17 (3): 86. DOI: 10.1136/eb-2013-101585.
12. Delange F. Iodine deficiency as a cause of brain damage. Postgraduate Medical Journal. 2001; 77 (906): 217–220. DOI: 10.1136/pmj.77.906.217.
13. Delange F. The role of iodine in brain development. Proc. Nutr. Soc. 2000: 59 (1): 75–79. DOI: 10.1017/S0029665100000094.
14. Ming Qian, Dong Wang B.A., William E. Watkins, Val Gebski, Yu Qin Yan, Mu Li, Zu Pei Chen. The effects of iodine on intelligence in children: a metaanalysis of studies conducted in China. Asia Pac. J. Clin. Nutr. 2005; 14 (1): 32–42.
15. Leung A.M., Brent G.A. Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8–9 years of age. Evidence-based Nursing. 2014; 17 (3): 86. DOI: 10.1136/eb-2013-101585.
16. Velasco I., Bath S.C., Rayman M.P. Iodine as Essential Nutrient during the First 1000 Days of Life. Nutrients. 2018 Mar 1; 10 (3). pii: E290. DOI: 10.3390/nu10030290.
17. Bleichrodt N., P.J.D. Drenth, Querido A. Effects of iodine deficiency on mental and psychomotor abilities. Am. J. Phys. Anthrop. 1980: (53): 55–67. DOI: 10.1002/ajpa.1330530110.
18. Shhepljagina L. A., Makulova N.D. Iodine and intellectual development of the child. Russian Мedical Journal. 2002; (7): 358–363 (in Russ.).
19. Shhepljagina L. A., Rimarchuk G.V., Vasechkina L.I. Iodine preparations in correction of cognitive impairment in children. M.: MedJekspertPress Publ., 2008: 230 (in Russ.).
20. Fedak I. R. Control and epidemiological studies of the effectiveness of regional programs for the prevention of iodine deficiency disorders in the Russian Federation. Moscow, 2008: 30 (in Russ.).
21. Moleti M., Sturniolo G., Trimarchi F., Vermiglio F. The changing phenotype of iodine deficiency disorders: a review of thirty-five years of research in north-eastern Sic ily. Ann. Ist. Super. Sanita. 2016; 52 (4): 550–557. DOI: 10.4415/ANN_16_04_15.
22. World Health Organization. Indicators for Assessing Iodine Deficiency Disorders and Their Control Through Salt Iodination. Geneva, 1994.
23. Dedov I.I., Mel’nichenko G.A., Fadeev V.V. Endicrinology. M.: GEOTAR-Media Publ., 2015: 416 (in Russ.).
24. Fadeev V.V. Thyroid gland diseases in the region of mild iodine deficiency: epidemiology, diagnosis, treatment. M.: Publishing House Vidar-M Publ., 2005: 240 (in Russ.).
25. Laurberg P., Pedersen K.M., Vestergaard H., Sigurdsson G. High incidence of multinodular toxic goiter in the elderly population in a low iodine intake area vs high incidence of Graves’ disease in the young in a high iodine intake area: copmarative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. J. Intern. Med. 1991; 229 (5): 415–420. DOI: 10.1111/j.1365-2796.1991.tb00368.x.
26. Laurberg P., Pedersen K.M., Hreidarsson A., Sigfusson N., Iversen E., Knudsen P.R. Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J. Clin. Endocrinol. Metab. 1998; 83 (3): 765–769. DOI: 10.1210/jcem.83.3.4624.
27. Kravtsova T.Yu., Zarivchatskiy M.F., Blinov S.A., Denisov S.A., Teplykh N.S., Kamenskikh E.D., Mugatarov I.N., Kolyvanova M.V. Tactical approaches for the management of elderly and senile patients with thyrotoxicosis in an outpatient practice of surgeons and therapists. Tavricheskiy MedikoBiologicheskiy Vestnik. 2017; 20 (3): 140–145 (in Russ.).
28. Marusenko I.M., Petrova E.G. Hyperthyroidism and atrial fibrillation. Rational Pharmacotherapy in Cardiology. 2017; 13 (3): 398–402 (in Russ.). DOI: 10.20996/1819-6446-2017-13-3-398-402.
29. Bugova L.A., Kondratieva L.A., Ametov A.S. Graves' disease and thyroid functional autonomy in the region of mild iodine deficiency. Clinical and Еxperimental Тhyroidology. 2011; 7 (4): 51–55 (in Russ.). DOI: 10.14341/ket20117451-55.
30. Tavrovskaya T.V., Morgunova T.B., Timofeyev A.V., Berestennikova L.N. Atrial fibrillation and thyrotoxicosis. Journal of Аrrhythmology. 2009; 56: 59–80 (in Russ.).
31. Vasil’yeva A.G., Kondrashkina O.V., Ardashev V.N., Stebletsov S.V. Heart rate variability in patients with thyrotoxicosis. Kremlin Medicine Journal. 2018; 1: 165–180 (in Russ.).
32. Serdechnaya E., Tatarskiy B., Kazakevich E. Frequency and prevalence of atrial fibrillation. Vrach (The Doctor). 2008; 7: 78–79 (in Russ.).
33. Indicators for Assessing Iodine Deficiency Disorders and their Control Programmes. Report of a joint WHO/ UNICEF/ICCIDD Consultations. 1993.
34. World Health Organization: Salt Reduction and Iodine Fortification Strategies in Public Health. Geneva, 2014.
35. Walker S.P., Wachs T.D., Gardner J.M., Lozoff B., Wasserman G.A., Pollitt E., Carter J.A. Child development: risk factors for adverse outcomes in developing countries. Lancet. 2007; 369: 145–157. DOI: 10.1016/S0140-6736(07)60076-2.
36. WHO. Guideline: fortification of food-grade salt with iodine for the prevention and control of iodine deficiency disorders. Geneva: World Health Organization, 2014.
37. WHO. Salt reduction and iodine fortification strategies in public health: report of a joint technical meeting convened by the World Health Organization and The George Institute for Global Health in collaboration with the International Council for the Control of Iodine Deficiency Disorders Global Network. Sydney: World Health Organization, 2013.
38. Gerasimov G.A. On WHO Guidelines “Fortification of food grade salt”. Clinical and Еxperimental Тhyroidology. 2014; 10 (4): 5–8 (in Russ.) DOI: 10.14341/ket201445-8.
39. Information on the prevalence, effectiveness of preventive measures and the consequences of iodine deficiency diseases in the Russian Federation. Federal state budgetary institution "National Medical Research Center of Endocrinology" G.A. Melnichenko, Ministry of Health of the Russian Federation. (in Russ.)
40. Møllehave L.T., Linneberg A., Skaaby T., Knudsen N., Ehlers L., Jørgensen T., Thuesen B.H. Trends in Costs of thyroid disease treatment in denmark during 1995–2015. Eur. Thyroid. J. 2018; 7 (2): 75–83. DOI: 10.1159/000485973. Epub 2018 Jan 10.
41. Gerasimov G.A.,van der Haar F., Lazarus J.H. A review of possible strategies for preventing iodine deficiency in the countries of South-Eastern Europe and Central Asia: 2009–2016. Clinical and Еxperimental Тhyroidology. 2017; 13 (4): 16–22 (in Russ.). DOI: 10.14341/ket9531.
42. Ismailov S.I., Rashitov M.M. Progress in the field of prevention of iodine deficiency diseases in the Republic of Uzbekistan (1998–2016). Clinical and Еxperimental Тhyroidology. 2016; 12 (3): 20–24 (in Russ.).
43. Bruno de Benoist, Erin McLean, Maria Andersson, Lisa Rogers. Iodine deficiency in 2007. Global progress since 2003. Food, Nutrition Bulletin. 2008; 29 (3): 195–202.
44. WHO: Iodine status worldwide: WHO Global Database on Iodine Deficiency. Geneva, 2004.
45. Rajwinder Harika, Mieke Faber, Folake Samuel, Judith Kimiywe, Afework Mulugeta and Ans Eilander Micronutrient Status and Dietary Intake of Iron, Vitamin A, Iodine, Folate and Zinc in Women of Reproductive Age and Pregnant Women in Ethiopia, Kenya, Nigeria and South Africa: A Systematic Review of Data from 2005 to 2015. Nutrients. 2017; 9: 1096. DOI: 10.3390/nu9101096.
46. Sustaining IDD programs in Eastern Europe. IDD Newsletter. 2016; 44 (4): 14–15.
47. Ershow A.G., Skeaff S.A., Merkel J.M., Pehrsson P.R. Development of Databases on Iodine in Foods and Dietary Supplements. Nutrients. 2018; Jan. 17; 10 (1). pii: E100. DOI: 10.3390/nu10010100.
48. Troshina E.A. Diseases associated with iodine deficiency: history lessons and decision-making time. Problems of endocrinology. 2011; 57 (1): 60–65 (in Russ.). DOI: 10.14341/probl201157160-65.
49. Dedov I.I., Melnichenko G.A., Troshina E.A. Iodine Deficiency Disorders in the Russian Federation: Decision Time. Moscow: OAO “Konti Print” Publ., 2012 (in Russ.).
50. Suplotova L.A., Makarova O.B., Koval'zhina L.S., Sharuho G.V. Prophylaxis of iodine deficiency in the Tyumen region: success or failure? Clinical and Еxperimental Тhyroidology. 2015; 11 (3): 39–46 (in Russ.). DOI: 10.14341/ket2015339-46.
51. Gerasimov G.A. Sad statistics. Clinical and Еxperimental Тhyroidology. 2015; 11 (4): 6–12 (in Russ). DOI: 10.14341/ket201546-12.
52. Platonova N.M., Troshina E.A. Iodine deficiency: solving the problem in the world and in Russia (25 years of experience). Consilium Medicum. 2015; 04: 44–50 (in Russ.).
53. Troshina E.A., Platonova N.M., Panfilova E.A., Panfilov K.O. Analytical review on the results of monitoring of the main epidemiological characteristics of iodine deficiency diseases in the population of the Russian Federation for the period 2009–2015. Problems of Еndocrinology. 2018; 54 (1): 21–37 (in Russ.). DOI: 10.14341/pr9308.
54. Global action plan for the prevention and control of noncommunicable diseases 2013–2020. WHO Document Production Services, Geneva, Switzerland.
55. Methods of studying iodine deficiency diseases and monitoring their elimination. A guide for program managers. The second edition. Edited by G.A. Gerasimova. WHO, 2003. Moscow, 2003 (in Russ.).
56. WHO, UNICEF, ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination. – Geneva: World Health Organization, 2001.
57. World Health Organization. Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programmer managers. WHO, 2002.
58. World Health Organization, UNICEF, International Council for Control of Iodine Deficiency Disoders. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. Geneva: World Health Organization, 2007: 98.
59. Stepanova E.M., Morugova T.V. Monitoring the problem of iodine deficiency by the example of pregnant women living in iodine deficiency. Medicine. 2016; 4: 75–84 (in Russ.).
60. Platonov N.M. Iodine deficiency diseases (prevention, diagnosis, treatment and monitoring): dis. of DM. M.: State Institution “Endocrinological Research Center of the Russian Academy of Medical Sciences”, 2010. (in Russ.).
61. Rohner F., Zimmermann M., Jooste P., Pandav C., Caldwell K., Raghavan et al. Biomarkers of nutrition for development-iodine review. J. Nutr. 2014; 144 (8): 1322S–142S.
62. Setilla Dalili, Zahra Mohtasham-Amiri, Seyed Mahmood Rezvani, Arsalan Dadashi, Abdolreza Medghalchi, Simin Hoseini, Hajar Gholami-Nezhad, and Anis Amirhaki. The prevalence of iodine deficiency disorder in two different populations in northern province of iran: a comparison using different indicators recommended by WHO. Acta Medica Iranica. 2012; 50: 12.
63. Zimmermann M.B., Hess S.Y., Molinari L., De Benoist B., Delange F., Braverman L.E., Fujieda K, Ito Y, Jooste P.L., Moosa K., Pearce E.N., Pretell E.A., Shishiba Y. New reference values for thyroid volume by ultrasound in oidinesufficient schoolchildren: a World Health Organization/ Nutrition for Health and Development Iodine Deficiency Study Group Report. Am. J. Clin. Nutrit. 2004; 79: 231– 237. DOI: 10.1093/ajcn/79.2.231.
64. Spencer CA, Wang CC. Thyroglobulin measurement. Techniques, clinical benefits, and pitfalls. Endocrinol. Metab. Clin. North. Am. 1995; 24 (4): 841–863.
65. Ma ZF, Skeaff SA. Thyroglobulin as a biomarker of iodine deficiency: a review. Thyroid. 2014: 24 (8): 1195– 1209. DOI: 10.1089/thy2014.0052.
66. Zimmermann M.B., de Benoist B., Corigliano S., Jooste P.L., Molinari L., Moosa K., Pretell E.A., Al-Dallal Z.S., Wei Y., Zu-Pei C., Torresani T. Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. J. Clin. Endocrinol. Metab. 2006; 91 (12): 4881–4887. DOI: 10.1210/jc.2006-1370.
67. Zimmermann M.B., Aeberli I., Andersson M., Assey V., Yorg J.A., Jooste P., Jukić T., Kartono D., Kusić Z., Pretell E., San Luis T.O. Jr., Untoro J., Timmer A. Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100- 299 mug/L: a UNICEF/ICCIDD study group report. J. Clin. Endocrinol. Metab. 2013; 98 (3): 1271–1280. DOI: 10.1210/jc.2012-3952.
68. Shhepljagina L.A., Kurmacheva N.A. Iodine deficiency: a clinical value for pregnant and lactating women. Gynecology. 2011; 3: 63–66 (in Russ.).
69. Ismailov S.I., Rashitov M.M., Alimdzhanov N.A., Uzbekov K.K., Vakkasov M.H., Muratov T.F., Omilzhonov M.N. Study of the importance of thyroglobulin in the blood as a biomarker in assessing the severity of iodine deficiency disorders in Uzbekistan. Clinical and Еexperimental Тhyroidology. 2017; 13 (1): 20–25 (in Russ.). DOI: 10.14341/ket2017120-25.
70. Mel'nichenko G.A., Makolina N.P., Mihina M.S., Platonova N.M., Troshina E.A. "Pattern approach", or search for new templates. Comments on the article "Study of the importance of thyroglobulin in the blood as a biomarker in assessing the severity of iodine deficiency conditions in Uzbekistan". Clinical and Еxperimental Тhyroidology. 2017; 13 (2): 57–61 (in Russ.). DOI: 10.14341/ket2017257-61.
71. Mehran L. The impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran. Nutrients. 2017. Oct 30: 9 (11): E1194. DOI: 10.3390/nu9111194.
72. Samantha Lain, Caroline Trumpff, Scott D. Grosse, Antonella Olivieri and Guy Van Vliet. Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted? European Journal of Endocrinology. 2017; 177: D1–D12. DOI: 10.1530/EJE-17-0107.
73. Delange F. Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control. Thyroid. 1998; 8 (12): 1185–1192.
74. Vandevijvere S,. Coucke W., Vanderpas J., Trumpff C., Fauvart M. et al. Neonatal Thyroid-Stimulating Hormone Concentrations in Belgium: A Useful Indicator for Detecting Mild Iodine Deficiency? PLoS One. 2012; 7 (10): e47770. DOI: 10.1371/journal.pone.0047770.
75. Dedov I.I., Bezlepkina O.B., Vadi na T.A., Bajbarina E.N., Chumakova O.V., Karavaeva L.V. Bezlepkin A.S., Peterkova V.A. Screening for congenital hypothyroidism in the Russian Federation. Problems of Еndocrinology. 2018; 64 (1): 14–20 (in Russ.). DOI: 10.14341/probl8752.
76. Suplotova L.A., Makarova O.B., Koval'zhina L.S. Is neonatal hyperthyrotropinemia an indicator of the severity of iodine deficiency in a population? Clinical and Еxperimental Тhyroidology. 2015; 11 (3): 47–53 (in Russ.). DOI: 10.14341/ket2015347-53.
77. Gerasimov G.A. Russia is a country of contrasts. Clinical and Еxperimental Тhyroidology. 2017; 13 (2): 6–12 (in Russ.). DOI: 10.14341/ket201726-12.
Review
For citations:
Suplotova L.A., Makarova O.B., Kovalzhina L.S., Sharuho G.V. Assessment of indicators of medical and biological monitoring of iodine deficiency diseases. Bulletin of Siberian Medicine. 2019;18(1):96-108. (In Russ.) https://doi.org/10.20538/1682-0363-2019-1-96-108
Views:
1158
Email this article 