Frequency-temporal characteristics of sleep spindles in IGE with variable phenotypes in adults
https://doi.org/10.20538/1682-0363-2019-2-52-59
Abstract
A Mathematical Wave Analysis was conducted to study the frequency-temporal characteristics of sleep spindles in idiopathic generalized epilepsy (IGE) with variable phenotypes in adults. In resistant generalized tonic-clonic seizures (GTCS), the maximum duration of the stationary part of the sleep spindle in the 10–12Hz frequency band in the frontal and parietal regions was greater with Juvenile Absence Epilepsy compared with Juvenile Myoclonic Epilepsy and IGE with isolated GTCS. In patients with GTCS remission who took antiepileptic drugs (AED’s) in the anamnesis, the frequency-time characteristics of the sleep spindle were not different. In the entire group, the maximum duration of the stationary part of the sleep spindles in patients with IGE with a variable phenotype receiving AED’s was significantly less than in patients who stopped receiving AED’s. The revealed differences in the duration of the stationary part of the sleep spindles are due to various pathogenetic mechanisms underlying the different types of generalized seizures in adults, and can be used to refine the subtype of the IGE and evaluate the efficacy of the AED’s.
About the Authors
O. V. Grebenyuk
Siberian State Medical University (SSMU)
Russian Federation
Russian Federation
Grebenyuk Oleg V., PhD, Associate Professor, Neurology and Neurosurgery Department
2, Moscow Тrakt, Тоmsk, 634050
V. M. Alifirova
Siberian State Medical University (SSMU)
Russian Federation
Russian Federation
Alifirova Valentina M., DМ, Professor, Head of the Neurology and Neurosurgery Department
2, Moscow Тrakt, Тоmsk, 634050
M. V. Svetlik
Siberian State Medical University (SSMU)
Russian Federation
Russian Federation
Svetlik Michael V., PhD, Associate Professor, Neurology and Neurosurgery Department
2, Moscow Тrakt, Тоmsk, 634050
A. N. Levko
Siberian State Medical University (SSMU)
Russian Federation
Russian Federation
Levko Alena N., Chief Physician
2, Moscow Тrakt, Тоmsk, 634050
N. G. Kataeva
Siberian State Medical University (SSMU)
Russian Federation
Russian Federation
Kataeva N.G., DМ, Professor, Neurology and Neurosurgery Department
2, Moscow Тrakt, Тоmsk, 634050
References
1. Levchuk I.P., Kostyuchenko M.B., Nazarov A.P., Gorobets A.A. Treatment of wounds during the stages of medical evacuation. Effective Рharmacotherapy. 2012; 28: 36–41 (in Russ.).
2. Tret’yakov A.A., Neverov A.N., Petrov S.V., Gatiatullin I.Z. Complex treatment of trophic ulcers of lower extremities and long-term nonhealing wounds (review of literature). Orenburg Medical Bulletin. 2016; 4 (16): 62–68 (in Russ.).
3. Krasnolutskaya V.N., Sesorova D.V. Modern approaches to treatment of purulent wounds. Central Scientific Bulletin. 2017; 5 (22): 10–12 (in Russ.).
4. Pleshkov V.G., Privol’nev V.V., Golub A.V. Treatment of chronic wounds. Bulletin of Smolensk State Medical Academy. 2015; 14 (2): 58–65 (in Russ.).
5. Ryabov A.L., Skalozub O.I., Lapin R.V. Treatment of purulent wounds with negative pressure. Surgery. Journal of Тhem. N.I. Pirogov. 2014; (6): 58–60 (in Russ.)].
6. Kazaryan N.S., Kozlov K.K., Bykov A.Yu., Kokorin S.V., Viktorov S.I. Treatment of patients with purulent wounds by applying aspiration-flow-washing drainage of a new design. Bulletin of the Russian Academy of Medical Sciences. 2013; 68 (12): 64–68 (in Russ.)].
7. Lipova E.V., Pokrovskiy K.A., Gryazeva N.V. The experience of using autologous platelet-rich plasma in treatment of long-lasting non-healing skin wounds. Annals of Surgery. 2012; (5): 41–44 (in Russ.).
8. Chiang N., Rodda O.A., Sleigh J., Vasudevan T. Effects of topical negative pressure therapy on tissue oxygenation and wound healing in vascular foot wounds. J. Vasc. Surg. 2017; 66 (2): 564–571. DОI: 10.1016/j.jvs.2017.02.050.
9. Yan D., Liu S., Zhao X., Bian H., Yao X., Xing J., Sun W., Chen X. Recombinant human granulocyte macrophage colony stimulating factor in deep second-degree burn wound healing. Medicine (Baltimore). 2017; 96 (22):е6881. DОI: 10.1097/MD.0000000000006881.
10. Popova T.V., Tolstikova T.G., Letyagin A.Yu., Zhukova N.A., Bgatova N.P., Rachkovskaya L.N., Kotlyarova A.A., Burmistrov V.A. Influence of the new ointment composition ag / tag and chitosan gel on treatment of experimental wounds of different etiology. Bulletin of Siberian Medicine. 2016; 15 (1): 47–54. (in Russ.)]. DОI: 10.20538/1682-0363-2016-1-47-54.
11. Bubenchikova V.N., Malyutina A.Yu., Novikova L.S., Grigoryan A.Yu., Zatolokina M.A., Zhilyaeva L.V. Wound healing activity of a gel based on thick extract of seasoned speckled grass. Fundamental Research. 2013; (8-1): 123–127 (in Russ.)].
12. Tret’yakov A.A., Petrov S.V., Neverov A.N., Shchetinin A.F. Treatment of purulent wounds. Surgery News. 2015; 23 (6): 680–687 (in Russ.).
13. Gorokhova A.S., Grigoryan A.Yu., Bezhin A.I., Pankrusheva T.A., Zhilyaeva L.V., Mishina E.S., Kobzareva E.V. Efficacy of immobilized form of benzalkonium chloride in treatment of purulent wounds. Surgery News. 2016; 24 (6): 539–545 (in Russ.). DОI: 10.18484/2305-0047.2016.6.539.
Review
For citations:
Grebenyuk O.V., Alifirova V.M., Svetlik M.V., Levko A.N., Kataeva N.G. Frequency-temporal characteristics of sleep spindles in IGE with variable phenotypes in adults. Bulletin of Siberian Medicine. 2019;18(2):52-59. https://doi.org/10.20538/1682-0363-2019-2-52-59
Views:
808
Email this article 