Mice experimental model of diabetes mellitus type ii based on high fat diet
L. V. Kapilevich,
A. N. Zakharova,
E. Yu. Dyakova,
T. A. Kironenko,
K. G. Milovanova,
J. G. Kalinnikova,
A. V. Chibalin https://doi.org/10.20538/1682-0363-2019-3-53-61
Abstract
An experimental model of the obesity and type II diabetes mellitus formation in C57BL/6 mice using a high fat diet was developed and tested. In the study, it was shown that mice feeding high-fat diet had a significant body weight gain during the 3rd week. By the end of the experiment, body weight has more than doubled. In mice that feed chow diet, body weight increased by 50%, by the end of the experiment It was shown that high fat diet also induced glucose tolerance, and the insulin concentration tripled. The data obtained confirm the adequacy of the experimental model of diabetes mellitus type II in mice.
About the Authors
L. V. Kapilevich
National Research Tomsk State University (NR TSU);
Siberian State Medical University (SSMU)
Russian Federation
Russian Federation
DM, Professor, Chief Researcher, Department of Sports Tourism, Sports Physiology and Medicine, 36, Lenin Av., Tomsk, 634050;
Senior Researcher, 2, Moscow Trakt, Tomsk, 634050
A. N. Zakharova
National Research Tomsk State University (NR TSU)
Russian Federation
Russian Federation
PhD, Associate Professor, Department of Sports Tourism, Sports Physiology and Medicine,
36, Lenin Av., Tomsk, 634050
E. Yu. Dyakova
National Research Tomsk State University (NR TSU)
Russian Federation
Russian Federation
DM, Professor, Department of Sports Tourism, Sports Physiology and Medicine,
36, Lenin Av., Tomsk, 634050
T. A. Kironenko
National Research Tomsk State University (NR TSU)
Russian Federation
Russian Federation
Lecturer, Department of Sports Tourism, Sports Physiology and Medicine,
36, Lenin Av., Tomsk, 634050
K. G. Milovanova
National Research Tomsk State University (NR TSU)
Russian Federation
Russian Federation
Post-graduate Student, Department of Sports Tourism, Sports Physiology and Medicine,
36, Lenin Av., Tomsk, 634050
J. G. Kalinnikova
National Research Tomsk State University (NR TSU)
Russian Federation
Russian Federation
Senior Lecturer, Department of Sports Tourism, Sports Physiology and Medicine,
36, Lenin Av., Tomsk, 634050
A. V. Chibalin
National Research Tomsk State University (NR TSU);
Karolinska Institutet
Russian Federation
Russian Federation
Senior Researcher, Department of Sports Tourism, Sports Physiology and Medicine, 36, Lenin Av., Tomsk, 634050;
Associate Professor, Department of Molecular Medicine and Surgery, Integrative Physiology, 1, Solnavägen, Stockholm, 171 77, Sweden
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Review
For citations:
Kapilevich L.V., Zakharova A.N., Dyakova E.Yu., Kironenko T.A., Milovanova K.G., Kalinnikova J.G., Chibalin A.V. Mice experimental model of diabetes mellitus type ii based on high fat diet. Bulletin of Siberian Medicine. 2019;18(3):53-61. https://doi.org/10.20538/1682-0363-2019-3-53-61
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