Митохондриальная ДНК как кандидатный DAMP при критических состояниях

Недавно открытая роль митохондрий и митохондриальной ДНК в развитии иммунного ответа находится в фокусе внимания современных исследований. Растет число доказательств того, что митохондриальная ДНК, сохранившая некоторые характеристики генома древних α-протеобактерий, является иммунным стимулом для воспалительных реакций. Системный воспалительный ответ является частым осложнением при оперативных вмешательствах и различных травмах, и причины его развития не могут быть объяснены обычными подходами. В обзоре представлена информация о современном понимании механизмов развития воспаления, опосредованного мтДНК, в том числе системного воспалительного ответа, а также о факторах, регулирующих гомеостаз митохондрий и высвобождение мтДНК при различных патологических состояниях.

митохондриальная ДНК, DAMP, системный воспалительный ответ, сепсис, травма.

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