Mitochondrial DNA as DAMP in critical conditions
E. V. Grigoriev,
R. R. Salakhov,
M. V. Golubenko,
A. V. Ponasenko,
D. L. Shukevich,
V. G. Matveeva,
A. S. Radivilko,
A. V. Tsepokina,
E. A. Velikanova,
R. S. Kornelyuk,
A. S. Ivkin https://doi.org/10.20538/1682-0363-2019-3-134-143
Abstract
The focus of the researchers’ attention today includes the recently discovered role of mitochondria in the immune response. Increasing evidence shows that mitochondrial DNA, in retaining some of their characteristics of the ancient α-proteobacteria’s genome, is a potent immune stimulus for inflammatory reactions. Systemic inflammatory response is a frequent complication in surgical interventions and various traumas, and its development cannot be explained using common conceptions. This review provides information on the current understanding of the development of inflammation mediated by mtDNA, including systemic inflammatory response, and on the mechanisms regulating mitochondrial homeostasis and mtDNA release in various pathological conditions.
About the Authors
E. V. Grigoriev
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases;
Kemerovo State Medical University (KSMU)
Russian Federation
Russian Federation
DM, Professor, Deputy Director for Scientific and Clinical Affairs, 6, Sosnoviy Blvd, Kemerovo, 650002;
Head of the Department of Anesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000
R. R. Salakhov
Research Institute of Medical Genetics, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
PhD, Researcher, Laboratory of Population Genetics,
10, Naberezhnaya Ushaiki Str., Tomsk, 634050
M. V. Golubenko
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases;
Research Institute of Medical Genetics, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
Leading Researcher, Laboratory for Genomic Medicine, 6, Sosnoviy Blvd, Kemerovo, 650002;
PhD, Senior Researcher, Laboratory of Population Genetics, 10, Naberezhnaya Ushaiki Str., Tomsk, 634050
A. V. Ponasenko
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
PhD, Head of the Laboratory for Genomic Medicine,
6, Sosnoviy Blvd, Kemerovo, 650002
D. L. Shukevich
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases;
Kemerovo State Medical University (KSMU)
Russian Federation
Russian Federation
DM, Head of the Laboratory for Critical Care, 6, Sosnoviy Blvd, Kemerovo, 650002;
Professor, Department of Anaesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000
V. G. Matveeva
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
PhD, Senior Researcher, Laboratory for Cell Technologies,
6, Sosnoviy Blvd, Kemerovo, 650002
A. S. Radivilko
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
PhD, Senior Researcher, Laboratory for Critical Care,
6, Sosnoviy Blvd, Kemerovo, 650002
A. V. Tsepokina
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Researcher, Laboratory for Genomic Medicine,
6, Sosnoviy Blvd, Kemerovo, 650002
E. A. Velikanova
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
PhD, Researcher, Laboratory for Cell Technologies,
6, Sosnoviy Blvd, Kemerovo, 650002
R. S. Kornelyuk
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases;
Kemerovo State Medical University (KSMU)
Russian Federation
Russian Federation
Researcher, Laboratory for Critical Care, 6, Sosnoviy Blvd, Kemerovo, 650002;
Assistant, Department of Anaesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000
A. S. Ivkin
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases;
Kemerovo State Medical University (KSMU)
Russian Federation
Russian Federation
Researcher, Laboratory for Genomic Medicine, 6, Sosnoviy Blvd, Kemerovo, 650002;
Resident, Department of Anaesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000
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Grigoriev E.V., Salakhov R.R., Golubenko M.V., Ponasenko A.V., Shukevich D.L., Matveeva V.G., Radivilko A.S., Tsepokina A.V., Velikanova E.A., Kornelyuk R.S., Ivkin A.S. Mitochondrial DNA as DAMP in critical conditions. Bulletin of Siberian Medicine. 2019;18(3):134-143. (In Russ.) https://doi.org/10.20538/1682-0363-2019-3-134-143
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